Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Aleksey V. Matveyenko"'
Autor:
Aleksey V. Matveyenko, Kuntol Rakshit
Publikováno v:
Diabetes
Type 2 diabetes mellitus (T2DM) is characterized by β-cell dysfunction as a result of impaired glucose-stimulated insulin secretion (GSIS). Studies show that β-cell circadian clocks are important regulators of GSIS and glucose homeostasis. These ob
Autor:
Quan Zhou, Maria Sörhede-Winzell, Douglas A. Melton, Shaimaa Hassoun, Jennifer H. R. Kenty, Aleksey V. Matveyenko, Matthew R. Brown, Caden D. Duffy, Adrian Veres, Björn Tyrberg, Patrik Rorsman, Michael Q. Slama, Lihua Chen, Quinn P. Peterson, Haiqiang Dou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused on generating pancreatic beta cells, considerable evidence indicates that glucagon secreti
Autor:
Peiyu Wang, Aleksey V. Matveyenko, Peter C. Butler, Scott E. Fraser, Madeline Rosenberger, Jason A. Junge, David Elashoff, Raymond C. Stevens, Tatyana Gurlo, Zhongying Wang, Kate L. White
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM (Fluorescence Lifetime Imaging Microscopy) to monitor oxidative phosphorylation and glycolysis in living islet cells before and after glucose stimulation. In healthy
Autor:
Anu Sharma, Chiara Dalla Man, James C. Andrews, Claudio Cobelli, Robert A. Rizza, Ron T. Varghese, Adrian Vella, Giuseppe De Nicolao, Aleksey V. Matveyenko, Nana Esi Kittah, Marcello C. Laurenti
Publikováno v:
Am J Physiol Endocrinol Metab
The characteristics of pulsatile insulin secretion are important determinants of type 2 diabetes pathophysiology, but they are understudied due to the difficulties in measuring pulsatile insulin secretion noninvasively. Deconvolution of either periph
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Supplemental O2 (hyperoxia) is necessary for preterm infant survival but is associated with development of bronchial airway hyperreactivity and childhood asthma. Understanding early mechanisms that link hyperoxia to altered airway structure and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449b3ac8cc280eb63f729a2e70e35c97
https://europepmc.org/articles/PMC8294620/
https://europepmc.org/articles/PMC8294620/
Autor:
Carrie J. Heppelmann, Subhasish Tapadar, Adegboyega K. Oyelere, Jin Sung Jang, Quinn P. Peterson, Aleksey V. Matveyenko, Chong Hyun Shin, Yun Fang Jia, Jin Xu, Subbiah Jeeva, Michael Q. Slama, Sang-Moo Kang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in
Autor:
Adrian Vella, Chiara Dalla Man, Marcello C. Laurenti, Aleksey V. Matveyenko, Giuseppe De Nicolao, James C. Andrews, Claudio Cobelli, Ron T. Varghese, Robert A. Rizza
Publikováno v:
JCI Insight
BACKGROUND: Metabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously associated with β cell dysfunction, would be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a60e999b93c34caf4976b62c7009b8
http://hdl.handle.net/11577/3391360
http://hdl.handle.net/11577/3391360
Autor:
Katherine L O'Grady, Brianne S Thicke, João F. Passos, Jennifer L. Rowsey, Olga P. Bondar, Aleksey V. Matveyenko, Brittany A. Eckhardt, David G. Monroe, Anthony B. Lagnado, Ravinder J. Singh, Sundeep Khosla, Daniel G. Fraser, Adrian Vella, Jolaine M. Hines, Joshua N. Farr, Andrew R. Thoreson, Kuntol Rakshit
Publikováno v:
JCI Insight
The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and
Autor:
Krutika S. Gaonkar, Sangeeta Dhawan, Kuntol Rakshit, Jingyi Qian, Aleksey V. Matveyenko, Christopher S. Colwell
Publikováno v:
Diabetes, vol 67, iss 5
Development of cell replacement therapies in diabetes requires understanding of the molecular underpinnings of β-cell maturation. The circadian clock regulates diverse cellular functions important for regulation of β-cell function and turnover. How
Publikováno v:
Metabolites
Metabolites, Vol 11, Iss 409, p 409 (2021)
Metabolites, Vol 11, Iss 409, p 409 (2021)
Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with oscillatory pulses superimposed on a basal secretion rate. Insulin