Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Richard A, Koup"'
Autor:
Rachel L. Rutishauser, Peter W. Hunt, Kyle A. Raymond, Daniel C. Douek, Theodore L. Roth, Rafick-Pierre Sekaly, Frederick Hecht, Alexander Marson, Carly E. Starke, Franziska Blaeschke, Steven G. Deeks, Christian Deo T Deguit, Christopher D. Pilcher, Joseph Hiatt, Joseph C. Mudd, Wenxuan Chen, Carolyn P Smullin, Joseph M. McCune, Satish K. Pillai, Melissa R. Krone, Richard A. Koup, Rebecca Hoh, Jeffrey N. Martin, Jason M. Brenchley, Lynn Wang, Rodrigo Matus-Nicodemos
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Autor:
Solène Fastenackels, Delphine Sauce, Jacques Boddaert, Victor Appay, Véronique Fabre-Mersseman, Laura Papagno, Rima Zoorab, Charles Bayard, Tinhinane Fali, Takuya Yamamoto, Richard A. Koup
Publikováno v:
JCI Insight
JCI Insight, American Society for Clinical Investigation, 2018, 3 (13), ⟨10.1172/jci.insight.95319⟩
JCI Insight, American Society for Clinical Investigation, 2018, 3 (13), ⟨10.1172/jci.insight.95319⟩
The maintenance of effective immunity over time is dependent on the capacity of hematopoietic stem cells (HSCs) to sustain the pool of immunocompetent mature cells. Decline of immune competence with old age may stem from HSC defects, including reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f69398a1b639647bd2f2287429d78e
https://hal.archives-ouvertes.fr/hal-02452400
https://hal.archives-ouvertes.fr/hal-02452400
Autor:
Rajendra Pahwa, Varghese K. George, David Huddleston, David R. Ambrozak, Suresh Pallikkuth, Lesley R. de Armas, Savita Pahwa, Louis Gonzalez, Richard A. Koup, Constantinos Petrovas, Eirini Moysi
Publikováno v:
The Journal of clinical investigation. 128(7)
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral the
Autor:
Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood, VRC 606 Study Team
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002493 (2018)
PLoS Medicine
PLoS Medicine
Background VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a mo
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev, John T. Patton
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activatio
Autor:
John R. Mascola, Jason M. Brenchley, Richard A. Koup, Eirini Moysi, Mirko Paiardini, Amarendra Pegu, Adrian B. McDermott, David R. Ambrozak, Constantinos Petrovas, Krystelle Nganou Makamdop, Daniel C. Douek, Sara Ferrando-Martinez, Sarah Andrews, David Palesch, George N. Pavlakis
Publikováno v:
The Journal of clinical investigation. 128(5)
LN follicles constitute major reservoir sites for HIV/SIV persistence. Cure strategies could benefit from the characterization of CD8+ T cells able to access and eliminate HIV-infected cells from these areas. In this study, we provide a comprehensive
Autor:
Richard A. Koup, Patrick Younan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Michael G. Katze, Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
PLoS Pathogens
PLoS Pathogens
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however
Autor:
John R. Mascola, Barney S. Graham, Peter B. Gilbert, Hong Zhao, Steven Lepore, M. Juliana McElrath, Michal Juraska, Jerome H. Kim, Morgane Rolland, Allan C. deCamp, Hongjun Bai, James I. Mullins, Robert T. Bailer, Robert J. O'Connell, Breana Hall, Sodsai Tovanabutra, Richard A. Koup, Shelly Karuna, Annemarie O'Sullivan, Elizabeth Adams, Shana Miller, Daniel E. Geraghty, Eric Sanders-Buell, Hasan Ahmed, Craig A. Magaret, Lindsay N. Carpp, Kalpana Dommaraju, Mario Roederer, Scott M. Hammer, Lawrence Corey, Kultida Poltavee, Raphael Gottardo, Matthew Zirui Tay, Andrew Fiore-Gartland, Nelson L. Michael, Derrick Goodman, Kim G. Wong, Patricia D'Souza, Magdalena E. Sobieszczyk, Lisa M. Frenkel, Paul T. Edlefsen, Meera Bose, Sheila Styrchak, Georgia D. Tomaras, Lennie Chen, Merlin L. Robb, Nicole Frahm, James G. Kublin
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0185959 (2017)
PLoS ONE
PLoS ONE
Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that
Autor:
Marlous L. Grijsen, John R. Mascola, Rebecca M. Lynch, Adam K. Wheatley, Jan M. Prins, Richard A. Koup, Madhu Prabhakaran, Godelieve J. de Bree, Adrian B. McDermott, Stephen D. Schmidt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
Background Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie
Autor:
Constantinos Petrovas, Manuel Leal, Rafael Luque, Diane V. Havlir, Kapil K. Saharia, Prudence Ive, Sara Ferrando-Martinez, Richard A. Koup, Anne F Luetkemeyer
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
[Background] Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d152ab4f9f6ccd7b0e32861f3e7c455
https://hdl.handle.net/10668/10229
https://hdl.handle.net/10668/10229