Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Srinivasan Yegnasubramanian, Jonathan W. Simons, William G. Nelson, Michael C. Haffner, Andries M. Bergman, Lodewyk F. A. Wessels, Tesa M. Severson, Matthew L. Freedman, Wilbert Zwart, Tracy Jones, Yanyun Zhu, Angelo M. De Marzo
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
Molecular Oncology
Molecular Oncology, 15(7), 1942-1955. Elsevier
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Autor:
Zhongyuan Zhang, W. Nathaniel Brennen, Angelo M. De Marzo, Alexandria Brame, Levent Trabzonlu, Sarah R. Amend, Denis Wirtz, Timothy E. G. Krueger, Ashley Kiemen, Amber E. de Groot, Kayla V. Myers, Kenneth J. Pienta, Vicente E Torres, Natalia H Nagy
Publikováno v:
Prostate
Background Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and
Autor:
William G. Nelson, Jonathan I. Epstein, Martine Roudier, Michael C. Haffner, Srinivasan Yegnasubramanian, Lawrence D. True, Peter S. Nelson, Wilbert Zwart, Angelo M. De Marzo
Publikováno v:
Nat Rev Urol
From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having topographically and morphologically distinct tumour foci. Sequencing studies have revealed tha
Autor:
William G. Nelson, Michael T. Marrone, Berrak Gumuskaya, Charles G. Drake, Fan Pan, Ian M. Thompson, Ibrahim Kulac, Jun O. Liu, Phyllis J. Goodman, Ines Benedetti, Lauren M. Hurwitz, M. Scott Lucia, Elizabeth A. Platz, Angelo M. De Marzo, Catherine M. Tangen, Javier A. Baena Del Valle, William B. Isaacs, Kathryn B. Arnold
Publikováno v:
Cancer Prev Res (Phila)
Aspirin and statin use may lower the risk of advanced/fatal prostate cancer, possibly by reducing intraprostatic inflammation. To test this hypothesis, we investigated the association of aspirin and statin use with the presence and extent of intrapro
Autor:
Susan L. Dalrymple, Yezi Zhu, Peter S. Nelson, Jun Luo, Jianfeng Xu, Alan K. Meeker, Samuel R. Denmeade, Emmanuel S. Antonarakis, S. Lilly Zheng, William B. Isaacs, Angelo M. De Marzo, Jody E. Hooper, Ilsa Coleman, John T. Isaacs, W. Nathaniel Brennen
Publikováno v:
Oncogene
The role of truncated androgen receptor splice variant-7 (AR-V7) in prostate cancer biology is an unresolved question. Is it simply a marker of resistance to 2nd-generation androgen receptor signaling inhibitors (ARSi) like abiraterone acetate (Abi)
Autor:
Kirsten Timms, Emmanuel S. Antonarakis, Jessica Hicks, Colin C. Pritchard, Bruce J. Trock, Angelo M. De Marzo, Tamara L. Lotan, Daniela C. Salles, Harsimar B. Kaur, William B. Isaacs, Minh Nguyen, Jerry S. Lanchbury, Sanjana Murali
Publikováno v:
Clinical Cancer Research. 26:4869-4881
Purpose:The ATM (ataxia telangiectasia mutated) gene is mutated in a subset of prostate cancers, and ATM mutation may confer specific therapeutic vulnerabilities, although ATM-deficient prostate cancers have not been well-characterized.Experimental D
Autor:
David Lim, Mindy K. Graham, Eva Corey, Tamara L. Lotan, Jonathan I. Epstein, Alan K. Meeker, Christopher M. Heaphy, Hao Wang, Mario A. Eisenberger, Angelo M. De Marzo, Christine Davis, Michael C. Haffner
Publikováno v:
Hum Pathol
BACKGROUND: Small cell neuroendocrine carcinoma (SCNC) of the prostate is an aggressive subtype with frequent TP53 mutation and RB1 inactivation, however the molecular phenotype remains an area of investigation. Here, we compared telomere lengths in
Autor:
Angelo M. De Marzo, Howard L. Parnes, Bora Gurel, M. Scott Lucia, Scott M. Lippman, Phyllis J. Goodman, Elizabeth A. Platz, John R. Barber, Frank Z. Stanczyk, William G. Nelson, Susan Chadid, Ian M. Thompson
Publikováno v:
Prostate
Background Intraprostatic inflammation is an emerging prostate cancer risk factor. Estrogens are pro-inflammatory while androgens are anti-inflammatory. Thus, we investigated whether serum sex steroid hormone concentrations are associated with intrap
Autor:
Ibrahim Kulac, Heidi Hempel Sullivan, Nathan Cuka, John R. Barber, Christopher M. Heaphy, Angelo M. De Marzo, Jiayun Lu, Tamara L. Lotan, Corinne E. Joshu, Karen S. Sfanos
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 29:668-675
Background: Given our previous findings that low intratumoral and high extratumoral mast cell numbers are associated with higher risk of biochemical recurrence after radical prostatectomy, we now assessed this relationship with race and the developme
Autor:
Karen S. Sfanos, Javier A. Baena Del Valle, Ibrahim Kulac, Onur Ertunc, Angelo M. De Marzo, Janielle P. Maynard
Publikováno v:
Molecular Cancer Research. 18:153-165
Chronic inflammation and African ancestry are implicated in prostate cancer aggressiveness, and inflammation-related genes are more highly expressed in prostate cancer in African American men. IL8 secretion is also implicated in prostate cancer progr