Zobrazeno 1 - 10
of 1 344
pro vyhledávání: '"11"'
Autor:
Amy Winship, Eva Dimitriadis
Publikováno v:
Journal of Reproductive Immunology. 125:32-38
Preeclampsia is a dangerous pregnancy complication, which is often associated with fetal growth restriction and can have serious life-long effects for both mother and baby. While the establishment of the placenta in the first trimester is the sentine
Autor:
Lisa A. Carey, Patrick L. Leslie, Yvonne L. Chao, Alessandro Porrello, Yi-Hsuan Tsai, Emily B. Harrison, Joel S. Parker, Subrata K. Ghosh, Brian C. Cooley, Chad V. Pecot, Amanda E.D. Van Swearingen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial. Additionally, the mechanisms explaining how cancers survive and exit LNs are largely unknown. H
Publikováno v:
Reproductive biomedicine online. 36(3)
Interleukin (IL)11 is a crucial regulator during the initiation of pregnancy in humans and mice. Elevated levels are detected in serum, placenta and decidua of women with pre-eclampsia. Elevated IL11 during placentation recapitulates pre-eclampsia in
Autor:
Eliza Kwiatkowska-Borowczyk, Anna Kowalik, Andrzej Marszałek, Hanna Dams-Kozlowska, Andrzej Mackiewicz, Sebastian Adamczyk, Ewa Leporowska, Anna Lewandowska, Katarzyna Gryska
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154520 (2016)
PLoS ONE
PLoS ONE
The incidence of cancer is constantly increasing. Chemo/radiotherapy is one of major methods of treating cancer. Although adverse chemo/radiotherapy events, such as anemia and neutropenia, can be successfully cured, thrombocytopenia is still problema
Publikováno v:
Biomedicine & Pharmacotherapy. 103:691-698
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease, which is associated with significant mortality and costs. The molecular mechanisms underlying the roles of cigarette smoke (an accepted risk factor for COPD) and gro
Autor:
Jong Min Baek, Kwon-Ha Yoon, Yoon-Hee Cheon, Sung Chul Kwak, Hong Young Jun, Ju-Young Kim, Myeung Su Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-18 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Claudins (Cldns) are well-established components of tight junctions (TJs) that play a pivotal role in the modulation of paracellular permeability. Several studies have explored the physiologic aspects of Cldn family members in bone metabolism. Howeve
Autor:
Alexander Gow, Farhad Ghoddoussi, Shane A. Perrine, Kathleen J. Maheras, Marcello Peppi, Matthew P. Galloway
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
Neuronal origins of behavioral disorders have been examined for decades to construct frameworks for understanding psychiatric diseases and developing useful therapeutic strategies with clinical application. Despite abundant anecdotal evidence for whi
Autor:
Francis G. Szele, Susana Frago, Nicholas B. Davies, Mirvat Surakhy, Martin Ducker, Claudia Bühnemann, Matthew P. Crump, Emma J. Carter, Sermet Can, Roman Trikin, A. Bassim Hassan, Jennifer Hughes
Publikováno v:
Scientific Reports
Hughes, J, Surakhy, M, Can, S, Ducker, M, Davies, N, Szele, F, Bühnemann, C, Carter, E, Trikin, R, Crump, M P, Frago, S & Hassan, A B 2019, ' Maternal transmission of an Igf2r domain 11 : IGF2 binding mutant allele (Igf2r I1565A ) results in partial lethality, overgrowth and intestinal adenoma progression ', Scientific Reports, vol. 9, no. 1, 11388 . https://doi.org/10.1038/s41598-019-47827-9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Hughes, J, Surakhy, M, Can, S, Ducker, M, Davies, N, Szele, F, Bühnemann, C, Carter, E, Trikin, R, Crump, M P, Frago, S & Hassan, A B 2019, ' Maternal transmission of an Igf2r domain 11 : IGF2 binding mutant allele (Igf2r I1565A ) results in partial lethality, overgrowth and intestinal adenoma progression ', Scientific Reports, vol. 9, no. 1, 11388 . https://doi.org/10.1038/s41598-019-47827-9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
The cation-independent mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R or IGF2R) traffics IGF2 and M6P ligands between pre-lysosomal and extra-cellular compartments. Specific IGF2 and M6P high-affinity binding occurs via domain-1
Autor:
Xiaochun Wei, Pengcui Li, Dongming Wang, Zhi Lv, Lu Li, Kaihang Wang, Xiang Geng, Jian Sun, Jiangong Lu, Xiaoming Cao, Lei Wei, Xiaohu Wang
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)References. 72(7)
OBJECTIVE To investigate the effects of a young systemic environment and growth differentiation factor 11 (GDF-11) on aging cartilage. METHODS A heterochronic parabiosis model (2-month-old mouse and 12-month-old mouse [Y/O]), an isochronic parabiosis
Autor:
Jing Peng, Cuntai Zhang, Jian Sun, Uta Dahmen, Olaf Dirsch, Haoshu Fang, Wei Dong, Anding Liu
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9)
Growth differentiation factor 11 (GDF11) has been implicated in a variety of aging conditions and the regulation of organ regeneration after injury; however, the role of GDF11 in liver ischemia reperfusion injury (IRI) is unknown. The aim of the curr