Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ye Zheng"'
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Jovylyn Gatchalian, Chin-San Loo, Bhargav Venkatraghavan, Yuqiong Liang, Josephine Ho, Ye Zheng, Diana C. Hargreaves, Mingjun Xie, Mathias Leblanc
Publikováno v:
Immunity
Summary Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg cell development and function are dependent on the transcription factor Foxp3. Here, we performed a genome-wide CRISPR
Autor:
Ye Zheng
Publikováno v:
Immunity. 47:211-214
Hayatsu et al. (2017) reveal that a FOXP3 mutant found in some patients afflicted with the autoimmune disease IPEX has broadened DNA-recognition specificity, directly repressing the expression of the gene encoding the transcription factor Batf. Their
Autor:
Kelly A. Remedios, Mark H. Ginsberg, Jane E. Klann, Justine Lopez, Brian G. Petrich, Lauren A. Mack, John T. Chang, Stephanie H. Kim, Ye Zheng, Patrick J. Metz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 198, iss 12
Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown to be involved in the regulation of T cell proliferation and function. In this study, we describe a role for talin in maintaining the homeostasis and
Autor:
Ye Zheng, Takatoshi Chinen, Arun K. Kannan, Jason D. Fontenot, Yongqiang Feng, Andrew G. Levine, Xiying Fan, Ulf Klein, Georg Gasteiger, Alexander Y. Rudensky
Publikováno v:
Nature Immunology. 17:1322-1333
Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by Treg
Publikováno v:
Current Protocols in Immunology. 126
Adipose tissue (AT) serves a crucial role in maintaining organismal metabolic homeostasis. Studies have demonstrated that AT is populated with a diverse array of immune cells that coordinate and regulate AT function. This adipo-immune system is highl
Autor:
Jailal N. G. Ablack, Mark H. Ginsberg, Jack D. Bui, Kelly A. Remedios, John T. Chang, Patrick J. Metz, Li-Fan Lu, Joseph M. Cantor, Jane E. Klann, Zhaoren He, Jocelyn G. Olvera, Stephanie H. Kim, Justine Lopez, Brian G. Petrich, Tiffani Tysl, Gene W. Yeo, Ye Zheng, Brigid S. Boland
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(12)
Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellula
Autor:
Jovan Shepherd, Yi Liu, Ye Zheng, Christian J. Maine, Guo Fu, Mohsen Sabouri-Ghomi, Changchun Xiao, Nengming Xiao, Seung Goo Kang, Cheng-Jang Wu, Shunbin Xu, Alicia Gonzalez-Martin, Li-Fan Lu, Zhe Huang, Wen Hsien Liu, Alexander Hoffmann, Hyun Yong Jin
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 213, iss 9
instname
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 213, iss 9
Xiao and collaborators show that miR-155 regulates T follicular helper cell development and function by suppressing the E3 ubiquitin ligase Peli1.
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the con
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa5ed3a272de3dc5bb9fdbe6d6cbcd4
http://hdl.handle.net/10486/685850
http://hdl.handle.net/10486/685850
Autor:
Lauren A. Mack, Christopher Liddle, Sigal Gery, Zhengshan Chen, Qi Cao, Henry Yang, Xianping Shi, Xuan Zhao, Haibo Sun, De-Chen Lin, Qi Chen, Jonathan W. Said, Serhan Alkan, Jing-Wen Bai, Ruishu Deng, Ling Wa Chong, Markus Müschen, Michael Downes, Ronald M. Evans, Jian-Jun Xie, Han Cho, Ruth T. Yu, Annette R. Atkins, Ye Zheng, Quan Zhen Li, H. Phillip Koeffler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 47
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec83e67eefb01b297a9051e42544974f
https://escholarship.org/uc/item/6wn972xv
https://escholarship.org/uc/item/6wn972xv
Autor:
Johan Auwerx, Ying Cui, Ruth T. Yu, Ronald M. Evans, Jianrong Wang, Hui Xiao, Caroline Zhang, Shuo Zhang, Annette R. Atkins, Ye Zheng, Na Zhang, Ruihong Zhu, Nanhai He, Michael Downes, Dexian Quan, Christopher Liddle, Qibin Leng, Chunhui Yang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while