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Autor:
So Jeong Kim, Sun Chang Kim, Mi-Yeon Kim, Hyo Jeong Kim, Hun Sik Kim, Jinju Lee, Woo Sun Choi
Publikováno v:
Journal of Ginseng Research, Vol 45, Iss 6, Pp 695-705 (2021)
Journal of Ginseng Research
Journal of Ginseng Research
Background Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research, Vol 2021 (2021)
Breast cancer is one of the most common cancers among females and is associated with high mortality and morbidity rates. Several studies have demonstrated that combination treatments with natural products and tamoxifen can improve the sensitivity and
Autor:
Valma Maria Lopes Nascimento, Ricardo Riccio Oliveira, Vitor Valério Maffili, Sânzio Silva Santana, Jaime Ribeiro Filho, Dalila Luciola Zanette, Marilda Souza Goncalves, Valéria M. Borges, Jonilson B. Lima, Rayra Pereira Santiago, J Ferreira, Caroline Conceição da Guarda, Isa Menezes Lyra, Thassila Nogueira Pitanga, Graziele Q. Carvalho, Milena Magalhães Aleluia, Magda Oliveira Seixas Carvalho
Publikováno v:
Inflammation Research. 70:823-834
This study tested the hypothesis that sickle red blood cell (SS-RBC) can induce inflammasome NLRP3 components gene expression in peripheral blood mononuclear cells (PBMCs) as well as interleukin-1β (IL-1β) and leukotriene B4 (LTB4) production. Addi
Autor:
Sonoko Harada, Hitoshi Sasano, Tomohito Takeshige, Kazuhisa Takahashi, Fumihiko Makino, Ayako Ishimori, Hisaya Akiba, Jun Ito, Yuuki Sandhu, Kei Matsuno, Ryo Atsuta, Yoko Katsura, Norihiro Harada
Publikováno v:
Allergology International, Vol 70, Iss 3, Pp 343-350 (2021)
Background Previous reports have shown that pathogen-associated patterns (PAMPs) induce the production of interleukin (IL)-1β in macrophages. Moreover, studies using mouse models also suggest that chitin, which acts as a PAMP, induces adjuvant effec
Autor:
Hossein Aghamollaei, Mohaddese Haddadi, Farshad Yazdani, Alireza Shahriary, Melad Sabzevare, Ali Karami
Publikováno v:
Immunopharmacology and Immunotoxicology. 43:452-460
Cornea injury of sulfur mustard (SM) is considered as the most devastating injuries to the eye. This study aimed to evaluate the single and combined effects of N-acetyl cysteine (NAC) and doxycycli...
Autor:
Rachel Thijssen, Edward Chew, Sarah S. Gabriel, Brandon J. Aubrey, Ashish Bajel, Andrew W. Roberts, Andreas Strasser, Marie Schoumacher, David A. Stroud, Chris D. Riffkin, Claudia Bruedigam, Donia M Moujalled, Natasha S Anstee, Tirta Mario Djajawi, Veronique Litalien, Ruth M. Kluck, Lin Tai, Andrew H. Wei, Thomas David Morley, Zhen Xu, Giovanna Pomilio, Sarah T. Diepstraten, Sarah MacRaild, Axel Kallies, Christoffer Flensburg, Boris Reljic, Steven W. Lane, Maoshan Chen, Catherine Chang, Gemma L. Kelly, David C. S. Huang, Fiona C. Brown, Sébastien Banquet, Michael A. Dengler, Melissa X Shi, Ian J. Majewski
Publikováno v:
Blood. 137:2721-2735
Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative treatment for patients with various leukemias. TP-53 controls apoptosis upstream of where BCL-2 and its prosurvival relatives, such as MCL-1, act. Therefore, targe
Publikováno v:
Inflammation. 44:1750-1761
The blood-brain barrier (BBB) is important for protecting the brain tissue by selectively exchanging substances between the blood and brain. The integrity of the BBB can be damaged by multiple factors, including oxidative stress and inflammation. Ram
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 1-8 (2021)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 1-8 (2021)
Despite being considered one of the most pathogenic helminth infections of companion animals, members of macrocyclic lactone class are the only drugs available for the prevention of heartworm disease caused by Dirofilaria immitis. Alarmingly, heartwo
Autor:
Adam C. Straub, Jianhai Du, Samit Ghosh, Heidi M Schmidt, Brenda McMahon, Jeffrey D. Lebensburger, Solomon F. Ofori-Acquah, Scott A. Hahn, Yekai Wang, Joo-Yeun Oh, Shuai Yuan, Katherine C. Wood, Jeffrey J. Baust, Sara E. Lewis, Dario A. Vitturi, Eric E. Kelley, Timothy N. Bachman, Rakesh P. Patel, Xena M. Williams
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Chronic hemolysis is a hallmark of sickle cell disease (SCD) and a driver of vasculopathy; however, the mechanisms contributing to hemolysis remain incompletely understood. Although XO (xanthine oxidase) activity has been shown to be eleva
Autor:
Bong Seok Choi
Publikováno v:
Clinical and Experimental Pediatrics, Vol 64, Iss 2, Pp 60-67 (2021)
Clinical and Experimental Pediatrics
Clinical and Experimental Pediatrics
Eosinophils are a type of granulocyte with eosinophilic granules in the cytoplasm that play an important role in allergic and parasitic diseases. Eosinophils are important in the pathogenesis of asthma, and many studies have examined the relationship