Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Robert A. Redd, Matthew Leventhal, Irene M. Ghobrial, Nikhil C. Munshi, Christopher J. Gibson, Jerome Ritz, Amin Nassar, Chip Stewart, Jihye Park, Romanos Sklavenitis-Pistofidis, Marzia Capelletti, Cody J. Boehner, David P. Steensma, Saud H. AlDubayan, Daniel Auclair, Lorenzo Trippa, Muhieddine M. Itani, Benjamin L. Ebert, Kalvis Hornburg, Shaadi Mehr, Mark Bustoros, Robert L. Schlossman, Henry Dumke, Jacob P. Laubach, Adam S. Sperling, Gad Getz, Salomon Manier, Paul G. Richardson, Eliezer M. Van Allen, Tarek H. Mouhieddine, Sabrin Tahri, Kenneth C. Anderson, Robert J. Soiffer, Daisy Huynh, Donna Neuberg, Brendan Reardon, Chia Jen Liu, Jonathan J Keats
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is t
Autor:
Christopher A. Haiman, Laura D. Kubzansky, Brianna M. Leonardo, Walter C. Willett, Lynn Rosenberg, Alpa V. Patel, Denis Nash, Loic Le Marchand, Shepherd H. Schurman, A. Heather Eliassen, Laura Beane-Freeman, Jae H. Kang, Long H. Nguyen, Lynne R. Wilkens, Jacqueline J. Flynn, Mingyang Song, James V. Lacey, Irene M. Ghobrial, Annie Cowan, Marina V. Magicheva-Gupta, Tim D. Spector, Paul W. Franks, Dale P. Sandler, Roger L. Milne, Maria Elena Martinez, Sohee Kwon, Raaj S. Mehta, Lorelei A. Mucci, Jane C. Figueiredo, Catherine R. Marinac, Jaime E. Hart, Zahra S. Fatehi, Karestan C. Koenen, Amit Joshi, Jorge E. Chavarro, Sebastien Ourselin, Brenda Kirpach, Christine M. Albert, Shreela V. Sharma, Meir J. Stampfer, Wenjie Ma, Daniel Sikavi, Sandra Deming-Halverson, Andrew T. Chan, John S. Brownstein, Janet E. Hall, Bijal A. Balasubramanian, Anusila Deka, Janet W. Rich-Edwards, Chuan-Guo Guo, Claire J. Steves, Jonathan Wolf, Julie R. Palmer, Fiona Bruinsma, Gabriella Andreotti, Michael E. Ernst, Anne M. Murray, Chun-Han Lo, Christopher D. Gardner, David A. Drew
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention
The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. W
Autor:
Jorge J. Castillo, Kirsten Meid, Maria Luisa Guerrera, Guang Yang, Irene M. Ghobrial, Steven P. Treon, Jacob D. Soumerai, Alan P Skarbnik
Publikováno v:
Blood. 135:1912-1915
Treon et al provide early clinical data supporting a theoretical rationale for continuing ibrutinib in patients receiving the drug during COVID-19 illness.
Autor:
Peter Sabbatini, Stacey Chuma, Rachid Baz, Jacob P. Laubach, Robert A. Redd, Alexandra Savell, Raymond P. Perez, Pamela S. Becker, Patrick Henrick, Kenneth C. Anderson, Oksana Zavidij, Chia Jen Liu, Kalvis Hornburg, Romanos Sklavenitis-Pistofidis, Michael Robbins, Kaitlen Reyes, Paul G. Richardson, Irene M. Ghobrial
Publikováno v:
Clinical Cancer Research. 26:344-353
Purpose: Ulocuplumab (BMS-936564) is a first-in-class fully human IgG4 monoclonal anti-CXCR4 antibody that inhibits the binding of CXCR4 to CXCL12. Patients and Methods: This phase Ib/II study aimed to determine the safety and tolerability of ulocupl
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Publikováno v:
Nature Immunology. 22:677-678
Single-cell RNA sequencing identifies an inflammatory subpopulation of mesenchymal stromal cells in patients with multiple myeloma.
Publikováno v:
Nature Medicine. 27:375-376
Single-cell RNA-sequencing can help in the prediction of drug resistance in patients with multiple myeloma.
Publikováno v:
Current opinion in oncology. 32(2)
Purpose of review The aim of the review is to describe recent advances in our understanding of how multiple myeloma interacts with its cellular and molecular neighbours in the bone marrow microenvironment, and how this may provide targets for prognos
Autor:
Jihye Park, James F. Sanchez, Tracey Stiller, Amrita Krishnan, Irene M. Ghobrial, Raju Pillai, Marzia Capelletti, Ibrahim Aldoss, Stephen J. Forman, Romanos Sklavenitis Pistofidis
Publikováno v:
Leukemia
Multiple myeloma (MM) patients have an 11-fold increased risk of developing myeloid neoplasms compared to the general population; however, acute lymphoblastic leukemia (ALL) is rarely observed. Given that both MM and the majority of ALL are of B cell
Autor:
Andreas Petri, Yawara Kawano, Charlotte Albæk Thrue, Daisy Huynh, Sakari Kauppinen, Karma Salem, Katsutoshi Kokubun, Mahshid Rahmat, Marianne B. Løvendorf, Satoshi Takagi, Jihye Park, Kenichi Nagano, Shokichi Tsukamoto, Roland Baron, Salomon Manier, Oksana Zavidij, Michaela R. Reagan, Irene M. Ghobrial, Marzia Capelletti, Aldo M. Roccaro
Publikováno v:
Tsukamoto, S, Løvendorf, M B, Park, J, Salem, K Z, Reagan, M R, Manier, S, Zavidij, O, Rahmat, M, Huynh, D, Takagi, S, Kawano, Y, Kokubun, K, Thrue, C A, Nagano, K, Petri, A, Roccaro, A M, Capelletti, M, Baron, R, Kauppinen, S & Ghobrial, I M 2018, ' Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche ', Leukemia, vol. 32, no. 8, pp. 1739-1750 . https://doi.org/10.1038/s41375-018-0161-6
Myeloma bone disease is a devastating complication of multiple myeloma (MM) and is caused by dysregulation of bone remodeling processes in the bone marrow microenvironment. Previous studies showed that microRNA-138 (miR-138) is a negative regulator o