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Publikováno v:
Biochemical and Biophysical Research Communications. 568:76-82
Medulloblastoma, the most common malignant brain tumor in children, consists of four molecular subgroups WNT, SHH, Group 3, and Group 4. Group 3 has the worst survival rate among the four subgroups and is characterized by the expression of retina-spe
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Publikováno v:
Biochemical and Biophysical Research Communications. 567:79-85
circRNAs have been suggested to modulate NSCLC tumorigenesis and drug resistance. Whether circSNX6 affects NSCLC remains unclear. In this study, we aim to investigate the role of circSNX6 in drug resistance of NSCLC exposed to cisplatin. RT-qPCR meth
Autor:
Guo-Bin Huang, Xinhai Zhu, Xiao-Hong Ma, Huan Ma, Qian Bi, Hong-Mei Jiang, Xihui Gan, Si-Yu Chen, Yong-Cong Shao, Silin Li, Hui-Ying Yang, Jinhu Guo, Ye-Bing Yang
Publikováno v:
Biochemical and Biophysical Research Communications. 567:9-16
The circadian clock plays a critical role in synchronizing the inner molecular, metabolic and physiological processes to environmental cues that cycle with a period of 24 h. Non-24 h and shift schedules are commonly used in maritime operations, and b
Publikováno v:
Biochemical and Biophysical Research Communications. 565:64-71
Neutrophil extracellular traps (NETs) are extracellular webs of DNA, histones and granular contents that are released by neutrophils to control infections. However, NETs that is not properly regulated can propagate inflammation and thrombosis. It was
Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma
Autor:
Masaru Kumagai, Shunsuke Nojiri, Atsunori Tsuchiya, Shuji Terai, Satoko Motegi, Takeki Sato, Suguru Takeuchi, Takashi Owaki, Yusuke Watanabe, Takahiro Iwasawa, Masahiro Ogawa, Yuzo Kawata, Hiroteru Kamimura
Publikováno v:
Biochemical and Biophysical Research Communications. 566:36-44
The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. T
Autor:
Jie Shuai, Guoping Cao, Jiayi Gu, Lili Dong, Lele Li, Yuping Dou, Zhaoxian Qiu, Yu Liu, Ningxin Pan, Aimin Sang
Publikováno v:
Biochemical and Biophysical Research Communications. 561:143-150
Retinal pigment epithelium (RPE) cell damage, including mitophagy-associated cell apoptosis, accelerates the pathogenesis of diabetic retinopathy (DR), a common complication of diabetes that causes blindness. Müller cells interact with RPE cells via
Autor:
Rou Li, Shan Jiang, Hui Xie, Nan Wang, Xiaoguang Yu, Ping Lin, Chi Liu, Huizhen Jia, Wei Wang
Publikováno v:
Biochemical and Biophysical Research Communications. 562:119-126
Background Prostate cancer (PCa) refers to malignant tumors derived from prostate epithelial cells, whose morbidity and mortality rates have been increasing every year. Although new drugs for treating prostate cancer continue to emerge, the unclear m
Autor:
Zhihui Lu, Jiaming Zhu, Jie Teng, Yi Fang, Yiran Liang, Yan Dai, Nana Song, Xiaoqiang Ding, Hong Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 559:48-55
Podocyte injury is associated with albuminuria and the progression of diabetic nephropathy (DN). MiR-34a, a p53-regulated miRNA, directly targets SIRT1 and contributed to DN progression. MiR-34a represses SIRT1 to activate p53 and establish a positiv
Autor:
Arisa Ochi, Yasumasa Ikeda, Naoki Kashihara, Kojiro Nagai, Kensei Taguchi, Masanori Tamaki, Ken-ichi Aihara, Hideharu Abe, Masashi Miyoshi, Craig R. Brooks, Hiroyuki Kadoya, Kenji Nishimura, Seiji Kishi
Publikováno v:
Biochemical and Biophysical Research Communications. 556:142-148
The relationship between cellular senescence and fibrosis in the kidney is being elucidated and we have identified it as therapeutic target in recent studies. Chronic kidney disease has also become a lifestyle disease, often developing on the backgro