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Autor:
William H. Walker
Publikováno v:
Semin Cell Dev Biol
Male fertility requires the continual production of sperm by the process of spermatogenesis. This process requires the correct timing of regulatory signals to germ cells during each phase of their development. MicroRNAs (miRNAs) in germ cells and sup
Publikováno v:
Seminars in Cell & Developmental Biology. 121:10-23
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytoto
Publikováno v:
Seminars in Cell & Developmental Biology. 121:63-70
Stem cells are specialized cells that can renew themselves through cell division and can differentiate into multi-lineage cells. Mesenchymal stem cells are adult stem cells that exist in animal and human tissues. Mesenchymal stem cells have the abili
Autor:
Wataru Morozumi, Yuki Iwata, Hideaki Hara, Masamitsu Shimazawa, Shinsuke Nakamura, Kota Aoshima, Satoshi Inagaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 2, Pp 211-221 (2021)
Trabecular meshwork (TM) regulates the intraocular pressure (IOP) through the control of aqueous humor outflow. Previous reports show that TM cells express 11 types of mechanosensitive molecules, including Piezo 1, which sense mechanical stimuli. How
Autor:
Josef Zamecnik, Anatoly Korotkov, Martha Feucht, Mark J. Luinenburg, Wim Van Hecke, Jeong H Lee, Caroline Mijnsbergen, Lieven Lagae, Till S. Zimmer, Wim G.M. Spliet, Floor E. Jansen, Katarzyna Kotulska, Jackelien van Scheppingen, Paolo Curatolo, Jasper J. Anink, Nam Suk Sim, Angelika Mühlebner, Pavel Krsek, Johannes A. Hainfellner, Sergiusz Jozwiak, Peter C. van Rijen, Erwin A. van Vliet, Diede W. M. Broekaart, David J. Kwiatkowski, Peter B. Crino, Anna Jansen, Eleonora Aronica, Anika Bongaarts, James D. Mills
Publikováno v:
Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, 47, 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and applied neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47, 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and applied neurobiology, 47(6), 796-811. Wiley-Blackwell
Aims Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway. Neurodevelopmental disorders, frequently present in TSC, are linked to cortical tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb0f7241374fa2ea6880a3964dbd171
https://dare.uva.nl/personal/pure/en/publications/microrna34a-activation-in-tuberous-sclerosis-complex-during-early-brain-development-may-lead-to-impaired-corticogenesis(54e41bc9-19fa-4850-90b0-8be834807835).html
https://dare.uva.nl/personal/pure/en/publications/microrna34a-activation-in-tuberous-sclerosis-complex-during-early-brain-development-may-lead-to-impaired-corticogenesis(54e41bc9-19fa-4850-90b0-8be834807835).html
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Autor:
Tadayoshi Okimoto, Takahiro Hiratsuka, Shusaku Kurogi, Masafumi Inomata, Tomohisa Uchida, Daisuke Kakisako, Teijiro Hirashita, Masatsugu Moriyama, Chisato Nakada, Yoshiyuki Tsukamoto, Naoki Hijiya, Yuka Hirashita, Tsuyoshi Etoh, Tomonori Akagi, Masaaki Kodama, Yoshitake Ueda, Kazuhiro Mizukami, Yoko Kudo, Koichi Honda, Kazunari Murakami, Hidefumi Shiroshita
Publikováno v:
Laboratory Investigation. 101:1036-1047
Mutations in RAS or BRAF are associated with poor prognosis and resistance to epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer (CRC). Despite their common ability to activate downstream genes such as MEK and ERK, the ther
Autor:
Patrick J. Hanley, Amy B. Hont, Catherine M. Bollard, Samuel O'Brien, Maja Stanojevic, Robert Ulrey, A. John Barrett, Conrad Russell Y. Cruz, Ashley Geiger, Haili Lang, Melanie Grant, Ping-Hsien Lee, Michael D. Keller, Anushree Datar
Publikováno v:
Cytotherapy
Background aims Preferentially expressed antigen in melanoma (PRAME) is a cancer/testis antigen that is overexpressed in many human malignancies and poorly expressed or absent in healthy tissues, making it a good target for anti-cancer immunotherapy.
Autor:
Cécile Macquin, Philippe Georgel, Hamid Merdji, Mohamad Kassem, Seiamak Bahram, Kei Kurihara, Aurore De Cauwer, Alicia Sibony, Julie Helms, Chérine Abou Fayçal, Raphaël Clere-Jehl, Laetitia Minniti, Ferhat Meziani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Septic shock and disseminated intravascular coagulation (DIC) are known to be characterized by an endothelial cell dysfunction. The molecular mechanisms underlying this relationship are, however, poorly understood. In this work, we aimed to investiga
Publikováno v:
Biochemical and Biophysical Research Communications. 565:64-71
Neutrophil extracellular traps (NETs) are extracellular webs of DNA, histones and granular contents that are released by neutrophils to control infections. However, NETs that is not properly regulated can propagate inflammation and thrombosis. It was