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Publikováno v:
J Invest Dermatol
The Ca(2+)-sensing receptor (CaSR) drives essential Ca(2+) and E-cadherin-mediated processes in the epidermis, including differentiation (Komuves et al., 2002), cell-to-cell adhesion (Tu et al., 2008) and epidermal barrier homeostasis in cells and yo
Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma
Autor:
Masaru Kumagai, Shunsuke Nojiri, Atsunori Tsuchiya, Shuji Terai, Satoko Motegi, Takeki Sato, Suguru Takeuchi, Takashi Owaki, Yusuke Watanabe, Takahiro Iwasawa, Masahiro Ogawa, Yuzo Kawata, Hiroteru Kamimura
Publikováno v:
Biochemical and Biophysical Research Communications. 566:36-44
The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. T
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
A major shortcoming of postischemic therapy for myocardial infarction is the no-reflow phenomenon due to impaired cardiac microvascular function including microcirculatory barrier function, loss of endothelial activity, local inflammatory cell accumu
Autor:
Lin Lilong, Jiahao Lu, Liu Dongyu, Li Zhihuan, Yi Zeng, Lin-Hui Qiu, Shilun Yang, Yin-Zhong Ma, Junlei Chang, Lisha Wang
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue origins on metabolic disorders can be varied in many ways but remains poorly defined. Here we report a comprehensive comparison of human MSCs derived from umbili
Autor:
Yanhong Li, Guiying Shi, Wei Liang, Haiquan Shang, Yunlin Han, Wenjie Zhao, Huiwu Li, Lin Bai, Chuan Qin
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS is associated with serious cardiovascular disease and remains the leading cause of mortality worldwide. Mesenchymal stem cells (MSCs) hav
Autor:
Ru-Chun Dai, Meilu Liu, Fen Xie, Yuling Liu, Jingqiong Xun, Qiongfei Zhou, Chan Li, Yueming Mei, Bo Wu
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Osteoporosis is a major public health concern for the elderly population and is characterized by fatigue load resulting in bone microdamage. The ability of bone mesenchymal stem cells (BMSCs) to repair bone microdamage diminishes with age,
Autor:
Lale Bakir, Ayman Al-Hendy, Prosper Igboeli, Amro Elsharoud, Hang-Soo Park, Jan M. McAllister, Sahar Esfandyari, Abdeljabar El Andaloussi, Rishi Man Chugh, Nahed Ismail, Mara Ulin, Mohamed Ali, Dalia Ashour, Alshimaa Aboalsoud
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features of PCOS. Human bone marrow me
Publikováno v:
Molecular and Cellular Biochemistry
Graphical abstract Human SARS Coronavirus-2 (SARS-CoV-2) has infected more than 170 million people worldwide and resulted in more than 3.5 million deaths so far. The infection causes Coronavirus disease (COVID-19) in people of all age groups, notably
Publikováno v:
Journal of Cellular and Molecular Medicine
Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α‐HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic or infection‐induced)
Autor:
Arisa Ochi, Yasumasa Ikeda, Naoki Kashihara, Kojiro Nagai, Kensei Taguchi, Masanori Tamaki, Ken-ichi Aihara, Hideharu Abe, Masashi Miyoshi, Craig R. Brooks, Hiroyuki Kadoya, Kenji Nishimura, Seiji Kishi
Publikováno v:
Biochemical and Biophysical Research Communications. 556:142-148
The relationship between cellular senescence and fibrosis in the kidney is being elucidated and we have identified it as therapeutic target in recent studies. Chronic kidney disease has also become a lifestyle disease, often developing on the backgro