Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Samir H. Barghout"'
Autor:
Zachary Blatman, Rose Hurren, Neil MacLean, Ahmed Aman, Taira Kiyota, Kazem Nouri, Rima Al-awar, Moustafa Abohawya, Mehakpreet Saini, Karen Arevalo, Samir H. Barghout, Aaron D. Schimmer, Troy Ketela, Geethu E. Thomas
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Autor:
Neil MacLean, Takenobu Nii, Michael Andreeff, Marcela Gronda, Lauren Heese, Andrew B. Leber, Emil F. Pai, Grace Egan, Hagop M. Kantarjian, Samir H. Barghout, Jo Ishizawa, Jonathan St-Germain, R. Eric Davis, Todd M. Link, Mark F. Mabanglo, Sarah F. Zarabi, Walid A. Houry, Rose Hurren, Martin Stogniew, Wencai Ma, Ondrej Halgas, Brian Raught, Yulia Jitkova, Kensuke Kojima, Keith S. Wong, Man Chun John Ma, Mark D. Minden, Vivian Ruvolo, Gautam Borthakur, Ran Zhao, Aaron D. Schimmer, Yuki Nishida
Publikováno v:
Cancer Cell
Summary The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein quality control by degrading misfolded proteins. Using genetic and chemical approaches, we showed that hyperactivation of the protease selectively
Autor:
Anna Rydlewski, Jaime O. Claudio, Karen Yee, Andre C. Schuh, Aaron D. Schimmer, Mahadeo A. Sukhai, Sanduni U. Liyanage, Thirushi P. Siriwardena, Mark D. Minden, Rose Hurren, Dawn Maze, Samir H. Barghout, Steven M. Chan, Amr Rostom, Hassan Sibai, Emily Heath, Dina Khalaf, Vikas Gupta, Marcela Gronda, Tracy Stockley, Tong Zhang, Andrzej Lutynski, Simon Kavanagh, Suzanne Kamel-Reid
Publikováno v:
Leukemia research. 68
We evaluated outcomes of 100 patients with high risk AML treated with Ida-FLAG induction as first-line therapy. 72 achieved remission with one cycle; 19 did not. High risk cytogenetics and TP53 mutations were associated with failure to achieve remiss