Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Samir H. Barghout"'
Autor:
Zachary Blatman, Rose Hurren, Neil MacLean, Ahmed Aman, Taira Kiyota, Kazem Nouri, Rima Al-awar, Moustafa Abohawya, Mehakpreet Saini, Karen Arevalo, Samir H. Barghout, Aaron D. Schimmer, Troy Ketela, Geethu E. Thomas
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Autor:
Neil MacLean, Takenobu Nii, Michael Andreeff, Marcela Gronda, Lauren Heese, Andrew B. Leber, Emil F. Pai, Grace Egan, Hagop M. Kantarjian, Samir H. Barghout, Jo Ishizawa, Jonathan St-Germain, R. Eric Davis, Todd M. Link, Mark F. Mabanglo, Sarah F. Zarabi, Walid A. Houry, Rose Hurren, Martin Stogniew, Wencai Ma, Ondrej Halgas, Brian Raught, Yulia Jitkova, Kensuke Kojima, Keith S. Wong, Man Chun John Ma, Mark D. Minden, Vivian Ruvolo, Gautam Borthakur, Ran Zhao, Aaron D. Schimmer, Yuki Nishida
Publikováno v:
Cancer Cell
Summary The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein quality control by degrading misfolded proteins. Using genetic and chemical approaches, we showed that hyperactivation of the protease selectively
Autor:
John E. Dick, Xiaoming Wang, Neil MacLean, Mark D. Minden, Samir H. Barghout, Rose Hurren, Dilshad H. Khan, Aaron D. Schimmer, Steven M. Chan, Yulia Jitkova, Sanduni U. Liyanage, Veronique Voisin, David Sharon, Joelle Soriano, Rashim Pal Singh, Gary D. Bader, Changjiang Xu, Marcela Gronda, Danny V. Jeyaraju, Eric R. Lechman
Publikováno v:
Blood. 132:1339-1339
The majority of mitochondrial proteins are encoded in the nucleus, translated in the cytoplasm and imported into the mitochondria. A subset of cysteine-rich proteins destined for the mitochondrial intermembrane space are oxidized and folded by the Mi
Autor:
Marcela Gronda, Mark D. Minden, Danny V. Jeyaraju, John E. Dick, Eric R. Lechman, Aaron D. Schimmer, Samir H. Barghout, Dilshad H. Khan, Changjiang Xu, Yulia Jitkova, Xiaoming Wang, Sanduni U. Liyanage, Joelle Soriano, David Sharon, Gary D. Bader, Veronique Voisin, Rose Hurren, Steven M. Chan, Neil MacLean
Publikováno v:
Blood. 130:881-881
The vast majority of mitochondrial proteins are encoded in the nucleus, translated in the cytoplasm and then imported into the mitochondria. A subset of these imported proteins are folded into their mature and functional forms in the mitochondrial in