Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Xinxin Ding"'
Autor:
Andreas Daiber, Pedro Felipe Malacarne, Xinxin Ding, Anna Gajos-Draus, Stefan Offermanns, Melina Lopez, Ralf P. Brandes, Jon O. Lundberg, Flávia Rezende
Publikováno v:
British Journal of Pharmacology. 178:1495-1506
Background and Purpose Organic nitrates such as nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment of angina or ischaemic heart disease. These compounds are prodrugs which release their nitro
Publikováno v:
Toxicol Sci
Previous studies have established that cytochrome P450 enzymes (CYPs) in both liver and lung are capable of bioactivating naphthalene (NA), an omnipresent air pollutant and possible human carcinogen, in vitro and in vivo. The aim of this study was to
Autor:
Senyan Liu, Stewart Sell, Lei Li, Kathleen G. Dickman, Changlin Mei, Xinxin Ding, Xiaochen Bao, Liang Ding, Jun Gu, Qing Yu Zhang
Publikováno v:
Toxicol Sci
The effect of variations in the expression of cytochrome P450 reductase (CPR or POR) is determined in mice with decreased POR expression to identify potential vulnerabilities in people with low POR expression. There is an age-dependent appearance of
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology
Guided tissue regeneration (GTR) is a promising treatment for periodontal tissue defects, which generally uses a membrane to build a mechanical barrier from the gingival epithelium and hold space for the periodontal regeneration especially the tooth-
Autor:
Han Nim Lee, Marisa S. Otegui, Annika Sonntag, Isabel Molina, Paul Ahlquist, Kaija Goodman, Xinxin Ding, Janice Pennington, Julio Paez-Valencia
Publikováno v:
Plant Cell
Pollen wall assembly is crucial for pollen development and plant fertility. The durable biopolymer sporopollenin and the constituents of the tryphine coat are delivered to developing pollen grains by the highly coordinated secretory activity of the s
Publikováno v:
Current Opinion in Plant Biology. 46:113-121
Autophagy mediates the delivery of cytoplasmic content to vacuoles or lysosomes for degradation or storage. The best characterized autophagy route called macroautophagy involves the sequestration of cargo in double-membrane autophagosomes and is cons
Autor:
Marisa S. Otegui, Richard D. Vierstra, Xiaoguo Zhang, Julio Paez-Valencia, Xinxin Ding, Richard S. Marshall, Patrick Lacey
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Reticulon (Rtn) proteins shape tubular domains of the endoplasmic reticulum (ER), and in some cases are autophagy receptors for selective ER turnover. We have found that maize Rtn1 and Rtn2 control ER homeostasis and autophagic flux in endosperm aleu
Autor:
Eileen White, Matthew Dodson, Aikseng Ooi, Yongyi Wei, Eli Chapman, Pawel R. Kiela, Aryatara Shakya, Qing Yu Zhang, Donna D. Zhang, Xinxin Ding, Pengfei Liu, Cody J. Schmidlin, Joe G.N. Garcia, Hui Li
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 51, Iss, Pp 101243-(2021)
Molecular Metabolism, Vol 51, Iss, Pp 101243-(2021)
Objective NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, li
Autor:
Yu Zhang, Wei Dai, Lan Wang, Xin Guan, Xinxin Ding, Yupo Ma, Chen Wang, Bin Shen, Jing Tian, Zhihua Ren, Yongping Jiang
Publikováno v:
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1698-1709 (2017)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor cells has been considered as a potential method to overcome blood supply shortages. Here, we report that functional human erythrocytes can be effi
Autor:
Michael Fasullo, Julian Freedland, Nicholas St. John, Xinxin Ding, Patricia A. Egner, Matthew Hartog, Cinzia Cera
Publikováno v:
Environmental and Molecular Mutagenesis. 58:217-227
P450 activity is required to metabolically activate many chemical carcinogens, rendering them highly genotoxic. CYP3A4 is the most abundantly expressed P450 enzyme in the liver, accounting for most drug metabolism and constituting 50% of all hepatic