Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Xin-Hua Feng"'
Autor:
Qinghua Liao, Mei Tang, Haitao Zhang, Liangyi Chen, Shuaifeng Li, Guoxuan Zhong, Jia Feng, Jianhui Zhao, Chenliang Wang, Huasong Lu, Yuan Si, Liuju Li, Xiaolei Cao, Manuel Kaulich, Li Li, Feifeng Zhu, Fangwei Wang, Tingbo Liang, Bin Zhao, Zongping Xia, Xin-Hua Feng, Haidong Li
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The human kinome comprises 538 kinases playing essential functions by catalyzing protein phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates investigation of normal and disease mechanisms. Here, we present Kinome
Autor:
Tao Huang, Jin Jin, Xin-tao Mao, Rong-bei Liu, Yu Zhang, Jiang-yan Zhong, Xin-Hua Feng, Zhengjun Gao, Ling-jie Huang, Jian-shuai Yu, Ke-qi Fan, Yuan Zhao, Qian Cao, Fei Wang, Peng Xiao, Yiyuan Li
Publikováno v:
Journal of Clinical Investigation. 129:2856-2871
Calcineurin acts as a calcium-activated phosphatase that dephosphorylates various substrates, including members of the nuclear factor of activated T cells (NFAT) family, to trigger their nuclear translocation and transcriptional activity. However, th
Autor:
Jian Zou, Jianping Jin, Xin-Hua Feng, Ting Liu, Jinquan Liu, Shuchen Gu, Mingjie Zheng, Meiling Zhao, Bo Yuan
Publikováno v:
Journal of Genetics and Genomics. 45:639-650
Smads are critical intracellular signal transducers for transforming growth factor-β (TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canon
Autor:
Jun Qin, Yan Jessie Zhang, Qirou Wu, Xiaojian Wang, Xin-Hua Feng, Fansen Meng, Pinglong Xu, Mengqiu Wang, Liming Wu, Shengduo Liu, Xia Lin, Fei Zhang, Seema Irani, Xiao Li, Jian Zou, Tingbo Liang, Ruyuan Zhou, Hai Song, Qian Zhang
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 2, p e3001122 (2021)
PLoS Biology, Vol 19, Iss 2, p e3001122 (2021)
The Hippo-YAP pathway responds to diverse environmental cues to manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) and determine its physiological activ
Autor:
Xin-Hua Feng, Xinran Li
Publikováno v:
Biochemical pharmacology. 180
The Transforming Growth Factor-β (TGF-β) signaling pathway plays a versatile role in diverse physiological and disease conditions. Outcomes of TGF-β signaling are divergent, sometimes even opposite, on cellular functions and disease progression th
Autor:
Yu Jiang, Vesa Kaartinen, Gustavo J. Martinez, Kentaro Tanaka, Xin-Hua Feng, Shinya Tanaka, Qiang Tian, Xiaohu Wang, Chen Dong, Tomohiro Kurosaki, Xiaowei Yan
Publikováno v:
The Journal of Experimental Medicine
Trim33, a modulator of TGF-β signaling, mediates the proinflammatory function of Th17 cells by the promotion of IL-17 and repression of IL-10 production. These cytokine expressions are regulated through an epigenetic mechanism in cooperation with Sm
Autor:
Vivekananda Shetty, Sung Yun Jung, Brett H. Graham, William E. Mitch, Yanlin Wang, Xin-Hua Feng, Tanqi Lou, Hui Peng, Jun Qin, Qianqian Wang, Zhaoyong Hu, Feng Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myoki
Autor:
Haitao Zhang, Sheng Ye, Hongxia Zhao, Chu Zhu, Huan Yan, Mei Tang, Lingyi Xu, Xinyan Ji, Bin Zhao, Li Li, Zongping Xia, Xiaoming Dai, Yuan Si, Xiaolei Cao, Xin-Hua Feng, Xiaocan Guo, Yu-Sheng Cong, Tingbo Liang, Qi Zhou
Publikováno v:
Cancer Research. 77:4868-4880
The Hippo pathway regulates cell proliferation, apoptosis, and stem cell self-renewal, and its inactivation in animal models causes organ enlargement followed by tumorigenesis. Hippo pathway deregulation occurs in many human cancers, but the underlyi
Autor:
Dewei Xu, Shuchen Gu, Fenfang Chen, Zongping Xia, Chen Ding, Yi Yu, Lei Wang, Wenjian Li, Chuang Sun, Mu Xiao, Sheng Ye, Yi Li, Bin Zhao, Ye-Guang Chen, Xin-Hua Feng, Xia Lin, Ye Li, Jun Qin, Pinglong Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10113-10118
Smad7 is a negative feedback product of TGF-β superfamily signaling and fine tunes a plethora of pleiotropic responses induced by TGF-β ligands. However, its noncanonical functions independent of TGF-β signaling remain to be elucidated. Here, we s
Autor:
Jun Qin, Ruyuan Zhou, Xinran Li, Fansen Meng, Pinglong Xu, Shasha Chen, Jian Zou, Kun-Liang Guan, Shiying Wu, Bin Zhao, Shengduo Liu, Junxian Wang, Qian Zhang, Xin-Hua Feng, Jianming Liu, Steven W. Plouffe
Publikováno v:
Nature cell biology
The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular and tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral defence. The correlation between cellular nutrient/physical status a