Zobrazeno 1 - 10
of 38
pro vyhledávání: '"William N. William"'
Autor:
Monique B. Nilsson, Jing Wang, Taghreed Hirz, Limo Nmi Chen, Jared J. Fradette, Xiangjun Tian, Mark J. McArthur, Diana Bell, Hampartsoum B. Barsoumian, Alissa Poteete, Jeffrey N. Myers, John V. Heymach, William N. William, Don L. Gibbons, Jose Augusto Monteiro de Oliveira Novaes, Irene Guijarro, Marlese Pisegna
Publikováno v:
Cancer Prevention Research. 14:313-324
We have previously demonstrated that PD-1 blockade decreased the incidence of high-grade dysplasia in a carcinogen-induced murine model of oral squamous cell carcinoma (OSCC). It remains unknown, however, whether there are additional factors involved
Autor:
Cheuk Hong Leung, Wayne L. Hofstetter, John V. Heymach, Alexandre Reuben, Myrna C.B. Godoy, Ara A. Vaporciyan, Padmanee Sharma, Yasir Elamin, Neda Kalhor, Robert R. Jenq, Junya Fujimoto, Tina Cascone, Anne S. Tsao, William N. William, Charles Lu, Frank E. Mott, Nadim J. Ajami, Don L. Gibbons, Jack A. Roth, David C. Rice, Luisa M. Solis, Hai T. Tran, Brett W. Carter, Lauren Averett Byers, Andrew Futreal, Lorenzo Federico, Annikka Weissferdt, Garrett L. Walsh, Reza J. Mehran, Chantale Bernatchez, George R. Blumenschein, Jennifer A. Wargo, Heather Lin, Cara Haymaker, Xiuning Le, Jonathan M. Kurie, Mehmet Altan, James P. Allison, Stephen G. Swisher, Edwin R. Parra, Boris Sepesi, Hitoshi Dejima, Frank V. Fossella, Jianjun Zhang, Bonnie S. Glisson, Mara B. Antonoff, Abdul Wadud Khan, Apar Pataer, Alejandro Francisco-Cruz, Ignacio I. Wistuba, Humam Kadara, J. Jack Lee, Ferdinandos Skoulidis
Publikováno v:
Nat Med
Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report the results of the phase 2 ran
Autor:
John V. Heymach, David C. Rice, Neda Kalhor, William N. William, Frank V. Fossella, Don L. Gibbons, Annikka Weissferdt, Vincent K. Lam, Stephen G. Swisher, Ara A. Vaporciyan, Frank E. Mott, Heather Lin, Boris Sepesi, J. Jack Lee, Ignacio I. Wistuba, Edwin R. Parra, Reza J. Mehran, Carmen Behrens, Anne S. Tsao, Mei Jiang, Jianjun Zhang, Tina Cascone, Cesar A. Moran, Charles Lu, Myrna C.B. Godoy, George R. Simon, Mara B. Antonoff
Publikováno v:
Clinical Cancer Research. 26:3525-3536
Purpose: Nintedanib enhances the activity of chemotherapy in metastatic non–small cell lung cancer (NSCLC). In this phase I/II study, we assessed safety and efficacy of nintedanib plus neoadjuvant chemotherapy, using major pathologic response (MPR)
Autor:
John V. Heymach, Jack A. Roth, William N. William, Jhanelle E. Gray, J. Kevin Hicks, Sonam Puri, Lara Lacerda, Xiuning Le, Jeff Lewis, Ming Tang, Stephen G. Swisher, Theresa A. Boyle, Yasir Elamin, Monique B. Nilsson, Jacqulyne P. Robichaux, Vassiliki A. Papadimitrakopoulou, Katherine L. Lovinger, Waree Rinsurongkawong, Huiying Sun, Marcelo V. Negrao, Emily Roarty, Jianjun Zhang, Bonnie S. Glisson, J. Jack Lee
Publikováno v:
Clinical Cancer Research. 24:6195-6203
Purpose: Osimertinib was initially approved for T790M-positive non–small cell lung cancer (NSCLC) and, more recently, for first-line treatment of EGFR-mutant NSCLC. However, resistance mechanisms to osimertinib have been incompletely described. Exp
Autor:
Richard P. Beckmann, Cathy Eng, David S. Hong, Howard A. Burris, Ricardo Martinez, Sameera R. Wijayawardana, Stefan C. Grant, Kathleen N. Moore, William N. William, Suzanne F. Jones, Funda Meric-Bernstam, Wei Zhang, Jeffrey R. Infante, Lisa Golden, Johanna C. Bendell, Manish R. Patel, Aimee Bence Lin
Publikováno v:
Clinical Cancer Research. 24:3263-3272
Purpose: Prexasertib, a checkpoint kinase 1 inhibitor, demonstrated single-agent activity in patients with advanced squamous cell carcinoma (SCC) in the dose-escalation portion of a phase I study (NCT01115790). Monotherapy prexasertib was further eva
Autor:
Neda Kalhor, William N. William, Ignacio I. Wistuba, Edward S. Kim, Stephen G. Swisher, Annikka Weissferdt, Boris Sepesi, Wayne L. Hofstetter, Tina Cascone, Kathryn A. Gold, Frank V. Fossella, Apar Pataer, Ara A. Vaporciyan, John V. Heymach, Diane D. Liu
Publikováno v:
The Annals of Thoracic Surgery. 105:418-424
Background Data from meta-analyses support the use of induction or adjuvant platinum-based chemotherapy for locally advanced non-small cell lung cancers (NSCLCs). This phase 2 study assessed the role of induction cisplatin and docetaxel followed by s
Autor:
Humam Kadara, Samar A. Jasser, Jing Wang, J. Jack Lee, Dong M. Shin, Sanchit Trivedi, Robert L. Ferris, Sara I. Pai, Mei Zhao, Christina McDowell, Jiping Wang, Curtis R. Pickering, Minh Ly Nguyen, Frederico O. Gleber-Netto, Heather M. Walline, Jeffrey N. Myers, Thomas E. Carey, Jiexin Zhang, William N. William
Publikováno v:
Cancer. 124:84-94
BACKGROUND Human immunodeficiency virus–infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their tumors in comparison with tho
Autor:
S. Andrew Peng, John V. Heymach, Lara Lacerda, Gustavo Schvartsman, J. Jack Lee, Marcelo F. Benveniste, Stephen G. Swisher, Emily Roarty, Frank V. Fossella, Jianjun Zhang, William N. William, Giorgios Bis
Publikováno v:
Lung Cancer. 112:90-95
Introduction Exploratory analysis of clinical trials in various tumor types have demonstrated potential improvements in overall response rate (ORR) to chemotherapy after exposure to vaccine-based immunotherapy. The objective of this retrospective stu
Autor:
Tina Cascone, P. Andrew Futreal, Chang-Jiun Wu, Lorenzo Federico, J. Jack Lee, Ignacio I. Wistuba, Harlan Robins, John V. Heymach, Carmen Behrens, Chantale Bernatchez, Alexandre Reuben, Runzhe Chen, Stephen G. Swisher, Jennifer A. Wargo, Rachel M. Gittelman, Jianhua Zhang, Marissa Vignali, Boris Sepesi, Latasha Little, Marie Andrée Forget, Jianjun Zhang, Jaime Rodriguez-Canales, Ryan O. Emerson, Erik Yusko, Vancheswaran Gopalakrishnan, Jianjun Gao, Kelly Quek, Luis M Vence, Sharon Benzeno, William N. William, Don L. Gibbons, Cara Haymaker, Jun Li, Padmanee Sharma, Christopher M. Tipton, Junya Fujimoto, James P. Allison, Edwin Roger Parra, Curtis Gumbs, Jiexin Zhang
Publikováno v:
Cancer Discovery. 7:1088-1097
Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens, were shown to alter tumor immunogenicity through T-cell responses. Here, we
Autor:
J. Jack Lee, Wenhua Lang, Vassiliki A. Papadimitrakopoulou, Scott M. Lippman, Edward S. Kim, Li Mao, Lei Feng, You Hong Fan, William N. William, Adel K. El-Naggar, Li Zhang, Mark W. Lingen, Waun Ki Hong, Pierre Saintigny, Jean Philippe Foy
Publikováno v:
JNCI: Journal of the National Cancer Institute. 110:250-257
We have previously shown that gene expression profiles of oral leukoplakia (OL) may improve the prediction of oral cancer (OC) risk. To identify new targets for prevention, we performed a systematic survey of transcripts associated with an increased