Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Shimon, Sakaguchi"'
Autor:
Atsushi Sugimoto, Hiroko Tani, Shimon Sakaguchi, Norihisa Mikami, Ryoji Kawakami, Tomoki Ikuta
Publikováno v:
Food Science & Nutrition, Vol 9, Iss 6, Pp 3200-3208 (2021)
Food Science & Nutrition
Food Science & Nutrition
FoxP3+ regulatory T cells (Tregs) are needed to suppress inflammatory diseases and maintain immune homeostasis. The suppressive function of Tregs can be used to control autoimmune or inflammatory diseases; therefore, it is well studied how Tregs can
Publikováno v:
Current Opinion in Immunology. 67:36-41
Naturally occurring FoxP3+CD4+ regulatory T (Treg) cells indispensable for the maintenance of immunological self-tolerance and homeostasis are instrumental in treating autoimmune and other immunological disorders. Stable function of natural Treg cell
Publikováno v:
Immunological Reviews. 296:104-119
Regulatory T cells (Tregs) expressing the transcription factor Foxp3 play a critical role in the control of immune homeostasis including the regulation of humoral immunity. Recently, it has become clear that a specialized subset of Tregs, T-follicula
Autor:
Shimon Sakaguchi, Norihisa Mikami, Kenji Ichiyama, James B. Wing, Naganari Ohkura, Atsushi Tanaka
Publikováno v:
Annual Review of Immunology. 38:541-566
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a functionally distinct T cell subpopulation actively engaged in the maintenanc
Autor:
Takayuki Kanazawa, Motohide Uemura, Yujiro Kidani, Makoto Yamasaki, Naganari Ohkura, Michinari Hirata, Taigo Kato, Kota Iwahori, Ryo Kato, Tetsuya Yoshida, Masaaki Sawada, Atsunari Kawashima, Yuichiro Doki, Shimon Sakaguchi, Akiko Morimoto-Okazawa, Takeshi Ujike, Kei Yamamoto, Kazutoshi Fujita, Koji Hatano, Yoko Yamamoto, Norio Nonomura, Hisashi Wada, Kentaro Nishida
Publikováno v:
International Immunology. 32:347-357
Objective CD4+CD8+ T cells are expressed in some cancer patients including those with renal cell carcinoma (RCC). However, no reports have mentioned the clinical importance of this expression. We evaluated the expression of CD4+CD8+ T cells in patien
Publikováno v:
Proc Natl Acad Sci U S A
Foxp3-expressing CD4(+)CD25(+) regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a
Autor:
Shimon Sakaguchi
Publikováno v:
The Journal of Experimental Medicine
Shimon Sakaguchi recounts the work that lead to the identification of regulatory T cells.
Regulatory T cells (Tregs) are indispensable for the establishment and maintenance of immunological self-tolerance. Their genetic anomalies or variations i
Regulatory T cells (Tregs) are indispensable for the establishment and maintenance of immunological self-tolerance. Their genetic anomalies or variations i
Autor:
Shimon Sakaguchi, Atsushi Tanaka
Publikováno v:
European Journal of Immunology. 49:1140-1146
Foxp3-expressing regulatory T (Treg) cells, which are indispensable for preventing autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into tumor tissues, which is often associated with poor prognosis in cancer pati
Autor:
Tomoyuki Yamaguchi, Shunsuke Teraguchi, Chikara Furusawa, Tomonobu M. Watanabe, Shimon Sakaguchi, Toshio Yanagida, Hiroaki Machiyama, Hideaki Fujita
Publikováno v:
International Immunology
A novel mechanism for Treg-mediated control of immune responses
The immune system in tolerance maintains cell diversity without responding to self-antigens. Foxp3-expressing CD25+CD4+ regulatory T cells (Tregs) inhibit T-cell activation through
The immune system in tolerance maintains cell diversity without responding to self-antigens. Foxp3-expressing CD25+CD4+ regulatory T cells (Tregs) inhibit T-cell activation through
Autor:
Eiichi Sato, Yosuke Togashi, Yoshiaki Nakamura, Takahiro Kinoshita, Akinori Sasaki, Takahiro Kamada, Hiromasa Morikawa, Yasuko Tada, Shimon Sakaguchi, Shota Fukuoka, Atsushi Tanaka, Christopher Tay, Hiroyoshi Nishikawa, Kohei Shitara, Akihito Kawazoe, Danbee Ha
Publikováno v:
Proceedings of the National Academy of Sciences. 116:9999-10008
PD-1 blockade is a cancer immunotherapy effective in various types of cancer. In a fraction of treated patients, however, it causes rapid cancer progression called hyperprogressive disease (HPD). With our observation of HPD in ∼10% of anti–PD-1 m