Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shadi Salloum"'
Autor:
Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,
Autor:
Jonathan Z. Li, Raymond T. Chung, Myung-Ho Kim, Jeffrey Y Wang, Kristina Lefteri, Lai Ping Wong, James Regan, Ce Gao, Shadi Salloum, Ruslan I. Sadreyev, Xu G. Yu, Zachary Manickas-Hill
Publikováno v:
The Journal of Infectious Diseases
medRxiv
medRxiv
We analyzed the plasma levels of interferons and cytokines, and the expression of interferon-stimulated genes in peripheral blood mononuclear cells in COVID-19 patients with different disease severity. Mild patients exhibited transient type I interfe
Autor:
Yongfu Huang, Esperance A. Schaefer, Yongju Zhao, Ming-Lung Yu, Haoju Wang, Zeng Tu, Chuanlong Zhu, Anna Lidofsky, Xiaoqiong Duan, Zhiwen Xu, Raymond T. Chung, Dachuan Cai, Shadi Salloum, Shilin Li, Limin Chen, Jian Hong, Wenyu Lin, Jacinta A. Holmes, Wenting Li, Sae Hwan Lee, Xiao Liu
Publikováno v:
Hepatology. 69:1004-1019
Long noncoding RNAs (lncRNAs) play a critical role in the regulation of many important cellular processes. However, the mechanisms by which lncRNAs regulate viral infection and host immune responses are not well understood. We sought to explore lncRN
Autor:
Eric Lefebvre, Raymond T. Chung, Bryan C. Fuchs, Jacinta A. Holmes, Peter Caravan, Shadi Salloum, Annie J. Kruger, Ricard Masia, Diego dos Santos Ferreira, Stephanie M. Rutledge, Pam Vig, Nadia Alatrakchi, Mozhdeh Sojoodi
Publikováno v:
Hepatology Communications
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease projected to become the leading cause of cirrhosis and liver transplantation in the next decade. Cenicriviroc (CVC), a dual chemokine receptor 2 and 5 antagonist, prevents macrophage
Autor:
Winona Wu, Esperance A. Schaefer, Erik DiGiacomo, Shadi Salloum, Kathleen E. Corey, Charles Carlton-Smith, Raymond T. Chung, Andrew Yang, Cynthia Brisac, Christina Mark, Wenyu Lin
Publikováno v:
Hepatology Communications
The biological factors that promote inflammation or nonalcoholic steatohepatitis (NASH) in the setting of nonalcoholic fatty liver disease remain incompletely understood. Clinical studies have demonstrated an association between obstructive sleep apn
Autor:
Nadia Alatrakchi, Jian Hong, Wenyu Lin, Jacinta A. Holmes, Cynthia Brisac, Stephane Chevaliez, Raymond T. Chung, Annie J. Kruger, Charlie Carlton-Smith, Esperance A. Schaefer, Victor Yang, Shadi Salloum
Publikováno v:
Journal of Hepatology. 65:972-979
Background & Aims Type I interferons (IFN) provide the first line of defense against invading pathogens but its mechanism of action is still not well understood. Using unbiased genome-wide siRNA screens, we recently identified IQ-motif containing GTP
Autor:
Jay Luther, Martin L. Yarmush, Nadia Alatrakchi, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Anna Lidofsky, Rohit Jindal, Shyam Sundhar Bale, Cynthia Brisac, Dahlene N. Fusco, Wenyu Lin, Esperance A. Schaefer, Jacinta A. Holmes
Publikováno v:
Hepatology. 64:1951-1968
HIV/HCV co-infection accelerates progressive liver fibrosis, however the mechanisms remain poorly understood. HCV and HIV independently induce profibrogenic markers TGFβ1 (mediated by reactive oxygen species (ROS)) and NFκB in hepatocytes and hepat
Autor:
Akif Altinbas, Kara W. Chew, Isabel S Seguin, Shadi Salloum, Nadia Alatrakchi, Ma Somsouk, Anna Lidofsky, Esperance A. Schaefer, Steven G. Deeks, Raymond T. Chung, Annie J. Kruger, Peter W. Hunt, Jenna L. Gustafson, Jacinta A. Holmes, Eoin R. Feeney, Hui Zheng, Kathleen E. Corey, Ricard Masia
Publikováno v:
The Journal of infectious diseases, vol 218, iss 9
BACKGROUND: Coinfection with human immunodeficiency virus (HIV) accelerates hepatitis C virus (HCV)–related liver fibrosis. Macrophages are triggered during both viral infections and are critical in liver inflammation/fibrogenesis. Liver fibrosis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714f9bbf778e71afa1b0494a7ec1f09d
https://europepmc.org/articles/PMC6151081/
https://europepmc.org/articles/PMC6151081/
Autor:
Wenting Li, Wenyu Lin, Zeng Tu, Baihai Jiao, Esperance A. Schaefer, Xiao Liu, Limin Chen, Xiaoqiong Duan, Dachuan Cai, Shadi Salloum, Shilin Li, Chunhui Yang, Dahlene N. Fusco, Jacinta A. Holmes, Raymond T. Chung, Yujia Li
Publikováno v:
Journal of Virology
Hepatitis C virus (HCV) infection has been shown to regulate microRNA 130a (miR-130a) in patient biopsy specimens and in cultured cells. We sought to identify miR-130a target genes and to explore the mechanisms by which miR-130a regulates HCV and hep
Autor:
Andrew Yang, Raymond T. Chung, Esperance A. Schaefer, Cynthia Brisac, Lee F. Peng, Christina Mark, Daniel L. Motola, Dahlene N. Fusco, Clary B. Clish, Shadi Salloum, Amy Deik, Wenyu Lin, James Meixiong
Publikováno v:
World Journal of Gastroenterology
AIM To characterize the role of apolipoprotein B100 (apoB100) in hepatitis C viral (HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases (TALENs), to generate human hepatoma cells with