Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert F. Paulson"'
Autor:
Shin Mineishi, Pan Zheng, Robert F. Paulson, W. Christopher Ehmann, Hiroko Shike, Bei Jia, K. Sandeep Prabhu, Todd D. Schell, Yi Zhang, Chenchen Zhao, Michael G. Bayerl, Hong Zheng, David F. Claxton, Leonard D. Shultz
Publikováno v:
J Leukoc Biol
The prognosis for acute myeloid leukemia (AML) relapse post allogeneic hematopoietic stem cell transplantation (alloSCT) is dismal. Novel effective treatment is urgently needed. Clinical benefit of alloSCT greatly relies on the graft-versus-leukemia
Autor:
Mohamed Trebak, Randall M. Rossi, K. Sandeep Prabhu, Robert F. Paulson, Ian Huffnagle, Tai Jung Lee, Ryan E. Yoast, Fenghua Qian, Svanjita Berry, Shaneice K. Nettleford, Bastihalli T. Diwakar
Publikováno v:
The FASEB Journal. 33:12838-12852
Prostaglandin D2 and its cyclopentenone metabolites [cyclopentenone prostaglandins (CyPGs)], Δ12prostaglandin J2 and 15-deoxy-Δ12,14-prostaglandin J2, act through 2 GPCRs, d-type prostanoid 1 and t...
Autor:
Dai Chen Wu, Andrew D. Patterson, James Fraser, Siyang Hao, Zhi Chun Lai, Jingwei Cai, Robert F. Paulson, Jie Xiang, Baiye Ruan
Publikováno v:
Blood Advances. 3:2205-2217
Anemic stress induces the proliferation of stress erythroid progenitors in the murine spleen that subsequently differentiate to generate erythrocytes to maintain homeostasis. This process relies on the interaction between stress erythroid progenitors
Publikováno v:
Blood. 132:2580-2593
Anemic stress induces a physiological response that includes the rapid production of new erythrocytes. This process is referred to as stress erythropoiesis. It is best understood in the mouse where it is extramedullary and utilizes signals and progen
Publikováno v:
Cells, Vol 9, Iss 3, p 634 (2020)
Cells
Cells
Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow
Autor:
Jong K. Yun, Taryn E. Dick, Robert F. Paulson, Su Fern Tan, Hong Gang Wang, David F. Claxton, Shantu Amin, Mark Kester, Arati Sharma, Laura M. Geffert, Dhimant Desai, Thomas P. Loughran, Arun Sharma, Kenichiro Doi, Todd E. Fox, Shailaja Hegde, Jeremy A. Hengst
Publikováno v:
Cancer Translational Medicine, Vol 3, Iss 4, Pp 109-121 (2017)
Aim: To further characterize the selectivity, mechanism of action, and therapeutic efficacy of the novel small molecule inhibitor, SKI-178. Methods: We used the state-of-the-art cellular thermal shift assay technique to detect “direct target engage
Autor:
Robert F. Paulson
The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, was the first hematopoietic niche discovered. The identity of EBI macrophages has thus far remained elusive. Given that Epo is essential for erythropoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfe009f79fc5660bba5fd74d0c91ad1
https://europepmc.org/articles/PMC6676130/
https://europepmc.org/articles/PMC6676130/
Autor:
Charyguly Annageldiyev, Yaxian Kong, Robert F. Paulson, Hong Zheng, Chenchen Zhao, Bei Jia, Hui Zeng, Joseph S. Fotos, K. Sandeep Prabhu, Arati Sharma, David F. Claxton
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-11 (2019)
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-11 (2019)
Background Successful treatment for acute myeloid leukemia (AML) remains challenging. Inhibiting immune checkpoint to enhance anti-tumor response is an attractive strategy for effective leukemia therapeutics. CD73 is a recently recognized immune chec
Publikováno v:
DNA and cell biology. 38(1)
The considerable amount of experimental evidence has defined the Hippo pathway as a tumor suppressive pathway and increased expression and/or activity of its oncogenic effectors is frequently observed in cancer. However, clinical studies have failed
Publikováno v:
Exp Hematol
Steady-state erythropoiesis generates new erythrocytes at a constant rate, and it has enormous productive capacity. This production is balanced by the removal of senescent erythrocytes by macrophages in the spleen and liver. Erythroid homeostasis is