Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Richard Salvi"'
Autor:
Peter F. Kador, Richard Salvi
Publikováno v:
Antioxid Redox Signal
SIGNIFICANCE: Oxidative stress contributes to vision, hearing and neurodegenerative disorders. Currently, no treatments prevent these disorders; therefore, there is an urgent need for redox modulators that can prevent these disorders. RECENT ADVANCES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f31b183ffbc0cc26728dee28396980
https://europepmc.org/articles/PMC9221172/
https://europepmc.org/articles/PMC9221172/
Autor:
Hong Sun, Jeanne M. Manalo, Dalian Ding, John Hicks, Richard Salvi, Fred A. Pereira, Rodney E. Kellems, Yang Xia, Hong Liu
Publikováno v:
The FASEB Journal. 34:15771-15787
Over 466 million people worldwide are diagnosed with hearing loss (HL). About 90% of HL cases are sensorineural HL (SNHL) with treatments limited to hearing aids and cochlear implants with no FDA-approved drugs. Intriguingly, ADA-deficient patients h
Autor:
Richard Salvi, Kelly Radziwon, Guang-Di Chen, Dalian Ding, Benjamin D. Auerbach, Xiaopeng Liu
Publikováno v:
Neuroscience
Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives rise to hyperacusis, a debilitating condition in which moderate intensity sounds are perceived abnormally loud. In an attempt to develop an animal model of loudnes
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Publikováno v:
Neurotox Res
Paraquat, a superoxide generator, can damage the cochlea causing an ototoxic hearing loss. The purpose of the study was to determine if deletion of Bak, a pro-apoptotic gene, would reduce paraquat ototoxicity or if deletion of Sirt3, which delays age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5198635a5e5780e596a3acdf24cd7f64
https://europepmc.org/articles/PMC8277768/
https://europepmc.org/articles/PMC8277768/
Publikováno v:
Neuroscience. 407:135-145
The central auditory system shows a remarkable ability to rescale its neural representation of loudness following long-term, low-level acoustic exposures; even when the noise is presented intermittently. Circadian rhythms exert potent biological effe
Publikováno v:
Neuroscience. 399:184-198
The cochlear nucleus, located in the brainstem, receives its afferent auditory input exclusively from the auditory nerve fibers of the ipsilateral cochlea. Noise-induced neurodegenerative changes occurring in the auditory nerve stimulate a cascade of
Publikováno v:
Neurotox Res
2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may
Blast-induced hearing loss suppresses hippocampal neurogenesis and disrupts long term spatial memory
Publikováno v:
Hear Res
Acoustic information transduced by cochlear hair cells is continuously relayed from the auditory pathway to other sensory, motor, emotional and cognitive centers in the central nervous system. Human epidemiological studies have suggested that hearing
Autor:
Kelly Radziwon, Richard Salvi
Publikováno v:
Hearing research. 395
Previous studies have demonstrated that auditory reaction time (RT) is a reliable surrogate of loudness perception in humans. Reaction time-intensity (RT-I) functions faithfully recapitulate equal loudness contours in humans while being easier to obt