Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rebecca A. Haeusler"'
Autor:
Jianwen Que, Prashant Rajbhandari, Utpal B. Pajvani, Li Qiang, Jun Qin, Qiongming Liu, Liheng Wang, Shuhui Ji, Luca Valenti, Yuliang Tang, Rebecca A. Haeusler, Quan Zhou, Junjie Yu, Xiaoguang Lei, Luis C. Santos, Yi Wang
Publikováno v:
Journal of Hepatology. 73:361-370
Background & Aims Obesity is a well-established risk factor for type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH), but the underlying mechanisms remain incompletely understood. Herein, we aimed to identify novel pathogenic factors (and p
Autor:
Enrico Bertaggia, Nicole C. Guilz, Jennifer R. Gamarra, Allison Hung, Niroshan Shanmugarajah, Rebecca A. Haeusler, Sei Higuchi, Tiara R. Ahmad
Publikováno v:
Journal of Biological Chemistry. 295:12545-12558
Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules that carry out physicochemical and signaling functions. A major site of BA action is the terminal ileum, where enterocytes actively reuptake BAs and express high levels
Autor:
Tomas Vaisar, John E. Hokanson, Daniel Mar, Jenny E. Kanter, Karol Bomsztyk, Shelley Barnhart, Karin E. Bornfeldt, Jay W. Heinecke, Mark J. Graham, Gregory L. Kinney, Masami Shimizu-Albergine, Janet K. Snell-Bergeon, Rebecca A. Haeusler, Baohai Shao, Farah Kramer, Rosanne M. Crooke, Clarence R. Manuel
Publikováno v:
Journal of Clinical Investigation. 129:4165-4179
Type 1 diabetes mellitus (T1DM) increases the risk of atherosclerotic cardiovascular disease (CVD) in humans by poorly understood mechanisms. Using mouse models of T1DM-accelerated atherosclerosis, we found that relative insulin deficiency rather tha
Autor:
Yu Lei, Henkjan J. Verkade, Vincent W. Bloks, Gilles Mithieux, Justina C. Wolters, Folkert Kuipers, Fabienne Rajas, Joanne A Hoogerland, Maaike H. Oosterveer, Jan Albert Kuivenhoven, Rebecca A. Haeusler, Niels L. Mulder, Aycha Bleeker, Jan Freark de Boer, Theo H. van Dijk, Trijnie Bos
Publikováno v:
Hepatology (Baltimore, Md.), 70(6), 2171-2184. John Wiley and Sons Ltd
Hepatology
Hepatology, Wiley-Blackwell, 2019, ⟨10.1002/hep.30778⟩
Hepatology, 70(6), 2171-2184. Wiley
Hepatology (Baltimore, Md.)
Hepatology
Hepatology, Wiley-Blackwell, 2019, ⟨10.1002/hep.30778⟩
Hepatology, 70(6), 2171-2184. Wiley
Hepatology (Baltimore, Md.)
It is well-established that, besides facilitating lipid absorption, bile acids act as signaling molecules that modulate glucose and lipid metabolism. Bile acid metabolism, in turn, is controlled by several nutrient-sensitive transcription factors. Al
Publikováno v:
J Clin Invest
De novo lipogenesis is tightly regulated by insulin and nutritional signals to maintain metabolic homeostasis. Excessive lipogenesis induces lipotoxicity, leading to nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Genetic lipogenic prog
Autor:
Rebecca A. Haeusler, Tiara R. Ahmad
Publikováno v:
Nat Rev Endocrinol
Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs) are notable for the fact that they were hiding in plain sight. BAs were well known for their requirement in dietary lipid absorption and biliary cholesterol
Autor:
Donovan A Argueta, Pedro A. Perez, Tiara R. Ahmad, Gary J. Schwartz, Chen Zhao, Rebecca A. Haeusler, Sei Higuchi, Nicholas V. DiPatrizio
Publikováno v:
Gut, vol 69, iss 9
Gut
Gut
ObjectivesLipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. In
Autor:
Ido Haimi, Rajasekhar Ramakrishnan, F. Rinninger, Jing Liu, Gabriella Belnavis, Joerg Heeren, Markus Heine, Alexander W. Fischer, Rebecca A. Haeusler, Henry N. Ginsberg, Samuel X. Lee, Christian Schlein
Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of the effect of insulin on HDL-C. FoxOs mediate a subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7677d728e25ccac8d61ef640415a9d
https://europepmc.org/articles/PMC5873864/
https://europepmc.org/articles/PMC5873864/
Autor:
Fanny Langlet, Eleuterio Ferrannini, Marcel Tarbier, Rebecca A. Haeusler, Domenico Accili, Stefania Camastra, Marc R. Friedländer
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 17, Iss, Pp 49-60 (2018)
Molecular Metabolism, vol. 17, pp. 49-60
Molecular Metabolism, Vol 17, Iss, Pp 49-60 (2018)
Molecular Metabolism, vol. 17, pp. 49-60
Objectives Hepatic insulin resistance is a hallmark of type 2 diabetes and obesity. Insulin receptor signaling through AKT and FOXO has important metabolic effects that have traditionally been ascribed to regulation of gene expression. However, wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4064ca45b3bfbca4c9831c6d634ace26
http://hdl.handle.net/11568/938795
http://hdl.handle.net/11568/938795
Publikováno v:
Nature reviews. Molecular cell biology. 19(1)
The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β-cells, genetic and acquired abnormalities of insulin action u