Zobrazeno 1 - 10
of 15 883
pro vyhledávání: '"RNA Interference"'
Autor:
Daniel G. Hurley, Jonathan Cebon, Joseph Cursons, Andreas Behren, Matthew Anaka, Miles C. Andrews, Edmund J. Crampin
Publikováno v:
Molecular Cancer
Background In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple mRNA transcripts, inducing reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb94476aa043e046d2932dea649e522
MicroRNAs (miRNAs) crucially modulate fundamental biologic processes such as angiogenesis. In the present study, we focused on the molecular function of miRNA-370-3p (miR-370) in regulating the angiogenic activity of endothelial cells (ECs). Transfec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aa23e93d80c91eef5d69c1fda31721
Autor:
Zhouyong Gao, Lin-Lin Ji, Zhao-nan Sun, Chun-Yang Wang, Feng Guo, Chun-Rui Yang, Fanjie Meng, Guangshun Wang, Shu-jun Wang, Zhi-Yu Guan, Wencheng Zhang, Fu-kai Feng
Publikováno v:
Immunology Letters. 237:17-26
Objective To understand the characteristics of DNA methyltransferase 3a (DNMT3a) in thymoma associated Myasthenia Gravis reveal its transcriptional regulator network as while as analyze the effect of DNMT3a on Rel/ nuclear factor-kappaB family (RelA/
Publikováno v:
Nucleic Acid Therapeutics. 31:245-270
RNA interference (RNAi), a gene regulatory process mediated by small interfering RNAs (siRNAs), has made remarkable progress as a potential therapeutic agent against various diseases. However, RNAi is associated with fundamental challenges such as po
Autor:
Hiroaki Takeuchi, Takaomi Ishida, Haruki Kitamura, Jin Gohda, Selase D. Deletsu, Shoji Yamaoka
Publikováno v:
Biochemical and Biophysical Research Communications. 567:106-111
Latency remains a barrier to achieving a sterilizing cure to HIV infection. It is thus important to find new host factor(s) to better understand maintenance of HIV latency and be exploited to develop new and more efficient latency reversing agents (L
Autor:
Sarah Bond, Saeho Chong, Tuyen Nguyen, Justin Darcy, Saket Agarwal, Maja M. Janas, Jing-Tao Wu, Samantha Chigas, Yongli Gu, Ruth Allard
Publikováno v:
Nucleic Acid Therapeutics
Serum protein interactions are evaluated during the drug development process since they determine the free drug concentration in blood and thereby can influence the drug's pharmacokinetic and pharmacodynamic properties. While the impact of serum prot
Autor:
Anna Bisbe, Martin Maier, Tuyen Nguyen, Martin Egli, Jennifer L. S. Willoughby, Muthiah Manoharan, Ivan Zlatev, Masaaki Akabane-Nakata, Matt Hettinger, Shigeo Matsuda, Hartmut Jahns, Christopher R. Brown, Nate Taneja, Rajar M. Manoharan, Kallanthottathil G. Rajeev, Klaus Charisse
Publikováno v:
Nucleic Acids Research. 50:1221-1240
A critical challenge for the successful development of RNA interference-based therapeutics therapeutics has been the enhancement of their in vivo metabolic stability. In therapeutically relevant, fully chemically modified small interfering RNAs (siRN
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Publikováno v:
The Plant Journal. 107:713-726
SUMMARYAs rapid changes in climate threaten global crop yields, an understanding of plant heat stress tolerance is increasingly relevant. Heat stress tolerance involves the coordinated action of many cellular processes and is particularly energy dema
Autor:
Joshua M. Corbin, Jonathan D. Wren, Constantin Georgescu, Chao Xu, Adam S. Asch, Maria J. Ruiz-Echevarria
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 337-351 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate