Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Pernille Vahl"'
Autor:
Mikkel H. Vendelbo, Steen Jakobsen, Niels Jessen, Ole Lajord Munk, Jørgen Frøkiær, Lars C. Gormsen, Elias Immanuel Ordell Sundelin, Nidal Al-Suliman, Steen B. Pedersen, Pernille Vahl
Publikováno v:
Sundelin, E I O, al-Suliman, N, Vahl, P, Vendelbo, M, Munk, O L, Jakobsen, S, Pedersen, S B, Frøkiær, J, Gormsen, L C & Jessen, N 2020, ' Metformin is distributed to tumor tissue in breast cancer patients in vivo : A 11 C-metformin PET/CT study ', Breast Cancer Research and Treatment, vol. 181, no. 1, pp. 107-113 . https://doi.org/10.1007/s10549-020-05621-6
Purpose: Epidemiological studies and randomized clinical trials suggest that the antidiabetic drug, metformin, may have anti-neoplastic effects. The mechanism that mediates these beneficial effects has been suggested to involve direct action on cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c10de03f0341c824645402f4e667420
https://pure.au.dk/portal/da/publications/metformin-is-distributed-to-tumor-tissue-in-breast-cancer-patients-in-vivo(a2f1283d-1e31-4dbb-a5ad-7f6959cb484a).html
https://pure.au.dk/portal/da/publications/metformin-is-distributed-to-tumor-tissue-in-breast-cancer-patients-in-vivo(a2f1283d-1e31-4dbb-a5ad-7f6959cb484a).html
Autor:
Ebbe Boedtkjer, Ninna C. S. Voss, Bent Honoré, Pernille Vahl, Thomas Dreyer, Mikkel B. Henningsen
Publikováno v:
Cancers, Vol 12, Iss 891, p 891 (2020)
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Autor:
Nicolai Jessen, Ebbe Boedtkjer, Stine F. Pedersen, Trine V Axelsen, Soojung Lee, Pernille Vahl
Publikováno v:
Lee, S, Axelsen, T V, Jessen, N, Pedersen, S F, Vahl, P & Boedtkjer, E 2018, ' Na +,HCO 3 –-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice ', Oncogene, vol. 37, no. 41, pp. 5569-5584 . https://doi.org/10.1038/s41388-018-0353-6
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7654b11d4dea51650c8a3abd257d60ad
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html