Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patrycja Gazinska"'
Autor:
Ioannis Roxanis, Laura Ramos Garcia, James M. Murphy, Sidonie Wicky John, Isabelle S Lucet, Andrew J. Kueh, Allison M. Beal, K. Aurelia Ball, Jyoti S. Choudhary, Cheree Fitzgibbon, Richard Newman, Jason W. Upton, Martin Sims, Lu Yu, George Ward, Gianmaria Liccardi, Winnie Fernando, Patrycja Gazinska, Naomi Guppy, Brad J. Geddes, Hyojin Kim, Samuel N. Young, Rachel O. Haich, Pascal Meier, Lung-Yu Liang, Mercedes Pardo, Tomoko Smyth, John Bertin, Tencho Tenev, Alessandro Annibaldi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL o
Autor:
Thomas Hardiman, Patrycja Gazinska, Jelmar Quist, Sarah E Pinder, Fangfang Liu, Anita Grigoriadis
Publikováno v:
Cancer Research. 81:PS6-36
Purpose: To assess the frequency and prognostic relevance of germinal centres (GC) in cancer-free axillary lymph nodes (ALNs), in relation to stromal tumour-infiltrating lymphocytes (sTILs) and the presence of tertiary lymphoid structures (TLS) in th
Autor:
Cheryl Gillett, C. Toms, Julie Owen, Sarah Kernaghan, Holly Tovey, Andrew Tutt, Patrycja Gazinska, Judith M Bliss, Sarah Maguire, Sabine C. Linn, Maggie C.U. Cheang, Orsolya Sipos, Sarah E Pinder, Salpie Nowinski, Syed Haider, Nick Orr, Anita Grigoriadis, Jelmar Quist
Publikováno v:
Sipos, O, Tovey, H, Quist, J, Hyder, S, Nowinski, S, Gazinska, P, Kernaghan, S, Toms, C, Maguire, S, Orr, N, Linn, S, Owen, J, Gillett, C, Pinder, S, Bliss, J, Tutt, A, Cheang, M C U & Grigoriadis, A 2021, ' Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer : the TNT trial ', Annals of Oncology, vol. 32, no. 1, pp. 58-65 . https://doi.org/10.1016/j.annonc.2020.10.475
Annals of Oncology
Annals of Oncology
Background In the TNT trial of triple negative breast cancer (NCT00532727), germline BRCA1/2 mutations were present in 28% of carboplatin responders. We assessed quantitative measures of structural chromosomal instability (CIN) to identify a wider pa
Autor:
Kailiang Wu, Xiaojing Guo, Roberto Salgado, Fangfang Liu, Anita Grigoriadis, Arnie Purushotham, Tony Ng, Jelmar Quist, Sarah E Pinder, Thomas Hardiman, Patrycja Gazinska
Publikováno v:
NPJ Breast Cancer
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previously dem
Autor:
Duncan Wheatley, A. Thompson, Steven Gendreau, Sirwan Hadad, Louise Lim, Lackner, C Zummit, Arnie Purushotham, Nigel J Bundred, Paul N. Mainwaring, Darren Korbie, A Shia, Kelly Mousa, Carol L. O'brien, Robert G. Price, E.J. Macaskill, Peter Schmid, Jennifer J. Hu, Matt Trau, S. Pinder, S-J Sarker, Patrycja Gazinska, Timothy R. Wilson
Publikováno v:
Cancer Research. 79:P2-08
Background: Although preclinical data suggest that combining PI3K inhibitors with endocrine therapy may overcome resistance, results from randomized clinical trials have failed to identify a subgroup of patients that derive a substantial benefit. Thi
Autor:
Sarah Kernaghan, Judith M Bliss, Kirsten Timms, Mcu Cheang, Holly Tovey, Andrew Tutt, Syed Haider, A Grigoriadis, Salpie Nowinski, O Sipos, C. Toms, Jerry S. Lanchbury, Sabine C. Linn, Sarah E Pinder, Patrycja Gazinska, Investigators, Jelmar Quist
Publikováno v:
Cancer Research. 79:P1-06
Background A distinctive trait of triple negative breast cancer (TNBC) is the acquisition of genome wide highly aberrant copy number states, which is more evident in metastatic settings. The level of copy number alterations can be characterized by qu
Autor:
Jyoti S. Choudhary, Lu Yu, Snezana Susnjar, Andrew Tutt, Patty Wai, Frances Daley, Natasa Medic Milijic, Rachael Natrajan, Daniela Kolarevic, Sophie Postel-Vinay, Barrie Peck, Ioanna Mavrommati, Hannah Cottom, Gareth Muirhead, Gillian Farnie, Gerard P. Quinn, Eleanor Knight, Rebecca Marlow, Richard Buus, Patrycja Gazinska, Simon S. McDade, Sunil Pancholi, Lesley-Ann Martin, Philip A. Bland, Naomi Guppy, Maggie C.U. Cheang, Sarah Maguire, Fredrik Wallberg, Amy Gibson, Paul H. Huang, Daniela Novo, Keith Brennan, Divya Kriplani, Farzana Noor, Giulia Falgari, Erle Holgersen, Eamonn Morrison, Syed Haider, Holly E. Barker, Kalnisha Naidoo, Ioannis Roxanis, Lukas Krasny
Publikováno v:
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e592d50d40abfd2812812de9e1d658c
https://doi.org/10.1158/0008-5472.CAN-20-1822
https://doi.org/10.1158/0008-5472.CAN-20-1822
Autor:
Julie Owen, Cristina Naceur-Lombardelli, Fernanda Kyle-Cezar, Adrian Hayday, Anita Grigoriadis, Pierre Vantourout, Andrew Tutt, Dhruva Biswas, Patrycja Gazinska, Yin Wu, R T Woolf, Anna Lorenc
Publikováno v:
Science Translational Medicine. 11
Innate-like tissue-resident γδ T cell compartments capable of protecting against carcinogenesis are well established in mice. Conversely, the degree to which they exist in humans, their potential properties, and their contributions to host benefit
Autor:
Patrycja Gazinska, Julie Foster, Roxana Kashani, John Maher, Sophie Papa, Jane K. Sosabowski, Nia Emami-Shahri, Celia Cook
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1
The unprecedented efficacy of chimeric antigen receptor (CAR) T-cell immunotherapy of CD19+ B-cell malignancy has established a new therapeutic pillar of hematology–oncology. Nonetheless, formidable challenges remain for the attainment of comparabl
Autor:
Victoria Roulstone, Patrycja Gazinska, Alan Melcher, Andrew J. Hayes, Gareth J. Inman, Gianmaria Liccardi, Kevin J. Harrington, Naomi Guppy, Emma Davies, Pascal Meier, Jasbani H.S. Dayal, Joan Kyula-Currie, Kunzah Jamal, Henry G. Smith, Tencho Tenev, Ioannis Roxanis
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreover, resis