Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Norman Sachs"'
Autor:
Andrea L. Richardson, Norman Sachs, Deborah A. Dillon, Joan S. Brugge, Carman Man-Chung Li, Ron C. J. Schackmann, Laura M. Selfors, Mackenzie Boedicker, Hendrik J. Kuiken, Jane E. Brock, G. Kenneth Gray, Judy Garber, Hans Clevers, Jennifer M. Rosenbluth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, 11(1). Nature Publishing Group
Nature Communications
Nature Communications, 11(1). Nature Publishing Group
Recently, organoid technology has been used to generate a large repository of breast cancer organoids. Here we present an extensive evaluation of the ability of organoid culture technology to preserve complex stem/progenitor and differentiated cell t
Autor:
Kim E Boonekamp, Antoni P. A. Hendrickx, Benedetta Artegiani, Deborah A. Schaefer, Michael W. Riggs, Inha Heo, Devanjali Dutta, Robert J L Willems, Nino Iakobachvili, Roberta M. O'Connor, Gregory D. Bowden, Hans Clevers, Norman Sachs, Peter J. Peters
Publikováno v:
Nature Microbiology, 3(7), 814-823. Nature Publishing Group
Nature Microbiology, 3(7), 814. Nature Publishing Group
Nature Microbiology
Nature Microbiology, 3(7), 814. Nature Publishing Group
Nature Microbiology
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a
Autor:
Dong Wang, Shuofeng Yuan, Hin Chu, Bosco Ho-Yin Wong, Cun Li, Hans Clevers, Norman Sachs, Kwok-Yung Yuen, Xiaoyu Zhao, Wenjun Song, Kelvin K. W. To, Jasper Fuk-Woo Chan, Honglin Chen, Lei Wen, Man Chun Chiu, Jie Zhou, Vincent Kwok-Man Poon, Kenneth K. Y. Wong
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6822
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6822-6827. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6822
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6822-6827. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Significance Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on
Publikováno v:
Development, 144(6), 1107-1112. Company of Biologists Ltd
Development (Cambridge), 144(6), 1107-1112. Company of Biologists Ltd
Development (Cambridge, England), 144(6), 1107. Company of Biologists Ltd
Development (Cambridge), 144(6), 1107-1112. Company of Biologists Ltd
Development (Cambridge, England), 144(6), 1107. Company of Biologists Ltd
Multiple recent examples highlight how stem cells can self-organize in vitro to establish organoids that closely resemble their in vivo counterparts. Single Lgr5+ mouse intestinal stem cells can be cultured under defined conditions forming ever-expan
Autor:
François Vaillant, Jane E. Visvader, Antonia N. Policheni, Huiling Xu, Hans Clevers, Daniel H.D. Gray, Andrew Fellowes, Göknur Giner, Bianca D. Capaldo, Thomas Green, Stephen B. Fox, Geoffrey J. Lindeman, Norman Sachs, James R. Whittle, He K. Liu, Johanna F. Dekkers, Huei-Rong Chen, Elliot Surgenor, Gordon K. Smyth, Marco J Herold
Publikováno v:
Clinical Cancer Research, 26(15), 4120-4134. American Association for Cancer Research Inc.
Purpose: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metastatic estrogen receptor–positive (ER+) breast cancer, relapse is almost inevitable. This may, in part, reflect the failu
Autor:
J. S. Malik Peiris, Kenrie P Y Hui, Hans Clevers, John M. Nicholls, Norman Sachs, Michael C. W. Chan, Stan K H Chan, Rachel H H Ching
Publikováno v:
The Lancet Respiratory Medicine, 6(11), 846. Elsevier Limited
The Lancet Respiratory Medicine, 6(11), 846-854. Elsevier B.V.
The Lancet Respiratory Medicine, 6(11), 846-854. Elsevier B.V.
Summary Background Human airway organoids are three-dimensional cultures derived from stem cells, which self-organise in ex-vivo conditions to form so-called mini-airways. The cellular morphology of these cultures is physiologically similar to the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b706075cf55e60bd26c28625374c9f
https://dspace.library.uu.nl/handle/1874/377298
https://dspace.library.uu.nl/handle/1874/377298
Autor:
Harry Begthel, Fleur Weeber, Lodewyk F. A. Wessels, Marieke van der Ven, Robert G.J. Vries, Jeroen Korving, Karin Wind, Alexandra A. Duarte, Robert F Ernst, Anjali Vanita Balgobind, Isaac J. Nijman, Ruben van Boxtel, Sylvia F. Boj, Edwin Cuppen, Gergana Bounova, Sven Rottenberg, Arne Van Hoeck, Paul J. van Diest, Francis Blokzijl, Daphne Lelieveld, David A. Egan, Vittoria Zinzalla, Ana Gracanin, Emile E. Voest, Joep de Ligt, Oded Kopper, Hans Clevers, Marlous Hoogstraat, Ewa Gogola, Norman Sachs, Jürgen Moll
Publikováno v:
Cell. Elsevier B.V.
Cell, 172(1-2), 373. Cell Press
Cell, 172(1-2), 373. Cell Press
Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of human mammary epithelial organoids. Using this protocol, >100 primary and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09af33434d59ed1af2f2a710a33953ed
https://dspace.library.uu.nl/handle/1874/363752
https://dspace.library.uu.nl/handle/1874/363752
Autor:
Julian R. de Ruiter, Sohvi Blatter, Marieke van de Ven, Norman Sachs, Piet Borst, Stefano Annunziato, Hans Clevers, Arno Velds, Alexandra A. Duarte, Sven Rottenberg, Ewa Gogola, Jos Jonkers, Marco Barazas, Julia M. Houthuijzen
Publikováno v:
Nature Methods. Nature Publishing Group
Nature Methods, 15(2), 134. Nature Publishing Group
Nature Methods
Nature Methods, 15(2), 134. Nature Publishing Group
Nature Methods
Poly(ADP-ribose) polymerase inhibition (PARPi) is a promising new therapeutic approach for the treatment of cancers that show homologous recombination deficiency (HRD). Despite the success of PARPi in targeting HRD in tumors that lack the tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6f4f169e071848c26b60ce9532908c
https://pure.knaw.nl/portal/en/publications/9f4b6026-212a-479d-8563-8ad4a8b0ee84
https://pure.knaw.nl/portal/en/publications/9f4b6026-212a-479d-8563-8ad4a8b0ee84
Autor:
Alexandra Duarte, Alexandra A. Duarte, Ewa Gogola, Norman Sachs, Marco Barazas, Stefano Annunziato, Julian R. de Ruiter, Arno Velds, Sohvi Blatter, Julia M. Houthuijzen, Marieke van de Ven, Hans Clevers, Piet Borst, Jos Jonkers, Sven Rottenberg
Publikováno v:
Protocol Exchange.
Autor:
Dasja Pajkrt, Sylvie M. Koekkoek, Hans Clevers, Norman Sachs, Gerrit Koen, Katja C. Wolthers, Sabine M. G. van der Sanden
Publikováno v:
Emerging Microbes & Infections
Emerging Microbes & Infections, 7(1). Nature Publishing Group
Emerging Microbes and Infections, 7(1). Nature Publishing Group
Emerging microbes and infections, 7(1):00772. Nature Publishing Group
Emerging Microbes & Infections, 7(1). Nature Publishing Group
Emerging Microbes and Infections, 7(1). Nature Publishing Group
Emerging microbes and infections, 7(1):00772. Nature Publishing Group
Human enteroviruses frequently cause severe diseases in children. Human enteroviruses are transmitted via the fecal-oral route and respiratory droplets, and primary replication occurs in the gastro-intestinal and respiratory tracts; however, how ente