Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nelofer Syed"'
Publikováno v:
Journal of Neurological Surgery Reports
Journal of Neurological Surgery Reports, Vol 82, Iss 02, Pp e11-e16 (2021)
e16
e11
Journal of Neurological Surgery Reports, Vol 82, Iss 02, Pp e11-e16 (2021)
e16
e11
We present a case report of a 51-year-old left-handed male with a background of human papillomovairus 16-positive tonsil squamous cell carcinoma presenting with tonic-clonic seizure and a radiological diagnosis of secondary metastatic deposits. These
Autor:
Tim Crook, Eirinaios I. Vrettos, Antonis D. Tsiailanis, Marie-Isabel Aguilar, Thomas Mavromoustakos, Nelofer Syed, Georgios S. Markopoulos, Alexander Renziehausen, Mark P. Del Borgo, Robert E Widdop, Nisar Sayyad, Evangelos Kolettas, Andreas G. Tzakos, Sofia Kiriakidi, Baydaa Hirmiz
Publikováno v:
Free Radical Biology and Medicine. 160:391-402
Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Maximal surgical resection followed by radiotherapy and concomitant chemotherapy with temozolomide remains the first-line therapy, prolonging the survival
Autor:
Michaela Oblukova, Andreas G. Tzakos, Yiannis Deligiannakis, Romana Sokolová, Nelofer Syed, Dimitrios Galaris, Aikaterini Gemenetzi, Tim Crook, Paraskevi S. Gerogianni, Dimitrios A. Diamantis, Maria V. Chatziathanasiadou, Christina Papaemmanouil
Publikováno v:
Free Radical Biology and Medicine. 160:540-551
Natural antioxidants, like phenolic acids, possess a unique chemical space that can protect cellular components from oxidative stress. However, their polar carboxylic acid chemotype reduces full intracellular antioxidant potential due to limited diff
Publikováno v:
Metabolites
Volume 10
Issue 9
Metabolites, Vol 10, Iss 346, p 346 (2020)
Volume 10
Issue 9
Metabolites, Vol 10, Iss 346, p 346 (2020)
Metabolic regulation of immune cells has arisen as a critical set of processes required for appropriate response to immunological signals. While our knowledge in this area has rapidly expanded in leukocytes, much less is known about the metabolic reg
Autor:
Shuvolina Mukherjee, Aliasgar Moiyadi, Sanjeeva Srivastava, Nelofer Syed, Qingyu Zeng, Julianna Stylianou, Anita Mahadevan, Sridhar Epari, Rucha Gadre, Prakash Shetty, Graham Ball, Deeptarup Biswas, Pooja Jain
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology
Meningiomas are one of the most prevalent primary brain tumors. Our study aims to obtain mechanistic insights of meningioma pathobiology using mass spectrometry-based label-free quantitative proteome analysis to identifying druggable targets and pert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd395789e5037fced8928945c6ec21b
http://hdl.handle.net/10044/1/82289
http://hdl.handle.net/10044/1/82289
Autor:
Andrée Delahaye-Duriez, Julianna Stylianou, Kirill Shkura, Federico Roncaroli, Sarah R. Langley, Nelofer Syed, Albert J. Becker, Prashant K. Srivastava, Liisi Laaniste, Enrico Petretto, Qingyu Zeng, Marvin Johnson, Kevin O’Neill, Matthew Williams, Owen J. L. Rackham, Silvia Cases-Cunillera
Publikováno v:
Laaniste, L, Srivastava, P K, Stylianou, J, Syed, N, Cases-Cunillera, S, Shkura, K, Zeng, Q, Rackham, O J L, Langley, S R, Delahaye-Duriez, A, O'Neill, K, Williams, M, Becker, A, Roncaroli, F, Petretto, E & Johnson, M R 2019, ' Integrated systems-genetic analyses reveal a network target for delaying glioma progression ', Annals of clinical and translational neurology, vol. 6, no. 9, pp. 1616-1638 . https://doi.org/10.1002/acn3.50850
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)
Annals of Clinical and Translational Neurology
OBJECTIVE: To identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy discovery.METHODS: Using an integrated functional genomics approach, we prioritized networks associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9856ad195da8e008d955d780c30cc79
https://www.research.manchester.ac.uk/portal/en/publications/integrated-systemsgenetic-analyses-reveal-a-network-target-for-delaying-glioma-progression(289e59de-ac87-4ea5-992b-bc9d64d85778).html
https://www.research.manchester.ac.uk/portal/en/publications/integrated-systemsgenetic-analyses-reveal-a-network-target-for-delaying-glioma-progression(289e59de-ac87-4ea5-992b-bc9d64d85778).html
Publikováno v:
Microchemical Journal. 137:464-472
The utilization of counter-current chromatography (CCC) requires the assistance of the analytical instruments to measure the distribution constants (KC) values and to monitor the CCC running process. Due to the limitation of the conventional detectio
Autor:
Nelofer Syed, Simon Pacey, Rajesh Jena, Fiona Harris, Matthew Williams, Ramsay Khadeir, Bor-Wen Wu, Rachel Lewis, Stephen G. Ellis, Jane Evanson, Tomasz Matys, Dimitris Paraskevopoulos, John S. Bomalaski, Jim Thomson, Kate Smith, Xiaoxing Feng, R. Shaffer, Amanda Johnston, Tim Crook, Kevin O’Neill, Peter E Hall, Piers Plowman, Sarah Jefferies, Michael Sheaff, Peter W. Szlosarek
Purpose: Patients with recurrent high-grade gliomas (HGG) are usually managed with alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor. Preclinically, we showed that HGGs are a target for arginine depletion with pegargiminase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181ccb882015b1397d2e3eea9428fb31
http://hdl.handle.net/10044/1/82279
http://hdl.handle.net/10044/1/82279
Autor:
Nabil Hajji, Alexander Renziehausen, Su Li, Maria del Carmen Fernandez-Carranco, Alan Evans, Van Ren Sim, Rubeta N Matin, Bhavya Rao, Marco Merlano, Catherine A. Harwood, Justin Stebbing, Laura Lattanzio, Nelofer Syed, Lynda Weir, Cristiana Lo Nigro, Kevin O’Neill, Andreas G. Tzakos, Charlotte M. Proby, Antonio Vega-Rioja, He-Xiao Wang, Peter W. Szlosarek, Alastair M. Thompson, Colin Fleming, Tim Crook
Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1876b0b1f9ba73775c7e2425f9f2c4c
https://hdl.handle.net/10668/13242
https://hdl.handle.net/10668/13242
Autor:
Christos M. Chatzigiannis, Andreas G. Tzakos, Evgenios K. Stylos, Richard Perryman, Kevin O’Neill, Antonis D. Tsiailanis, Tim Crook, Alexander Renziehausen, Nelofer Syed
Publikováno v:
Molecular cancer therapeutics. 18(9)
The alkylating agent temozolomide (TMZ) is the first-line chemotherapeutic for glioblastoma (GBM), a common and aggressive primary brain tumor in adults. However, its poor stability and unfavorable pharmacokinetic profile limit its clinical efficacy.