Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Liron Bar-Peled"'
Autor:
Islam Baiev, Jochen K. Lennerz, Lesli A. Kiedrowski, Mohammed Usman Syed, Chendi Li, Rebecca S. Heist, Samuel J. Klempner, Dejan Juric, Aaron N. Hata, Mustafa Sakhi, Katerina A. Fella, Ryan B. Corcoran, Alexa G. Michel, Justin F. Gainor, Junbing Zhang, Liron Bar-Peled, Jessica J. Lin, Meagan B. Ryan, Noritaka Tanaka, Giulia Siravegna
Publikováno v:
Cancer Discovery. 11:1913-1922
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Autor:
Tatiani B. Lima, A.F.Z. Nascimento, Juliana Helena Costa Smetana, David M. Sabatini, Germanna Lima Righetto, Kuang Shen, Gustavo Fernando Mercaldi, Ana L S Silva, Liron Bar-Peled, Nadia Rasheed, Fabio C. Gozzo, Ricardo Aparicio
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we pres
Autor:
Michael Petrascheck, Liron Bar-Peled, Brian K. Kennedy, Elizabeth R Valentine, Rozina Kardakaris, Megan M. Blewett, Gregory M. Solis, Mark A. McCormick, Alice L Chen, Benjamin F. Cravatt, James R. Williamson
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficie
Autor:
Ping Jiang, Enrique Saez, Benjamin D. Horning, Radu M. Suciu, Esther K. Kemper, Thomas A Paul, Keriann M. Backus, Jose Olucha, Liron Bar-Peled, Melissa M. Dix, Reuben J. Shaw, Taka-Aki Ichu, Matthew Merrill Hayward, Bernard P. Kok, Ekaterina V. Vinogradova, Nathan T. Ihle, Zhou Zhu, Max W. Chang, Robert U. Svensson, Benjamin F. Cravatt
Publikováno v:
Cell. 171:696-709.e23
The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmaco