Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joseph E. Powell"'
Autor:
Adam Ameur, Aaron L. Statham, Vaughan J. Carr, Marcel E. Dinger, Sini Nagpal, David Thomas, Greg Gibson, Mark J. Cowley, Robyn L. Woods, Christopher M. Reid, Moeen Riaz, Emma M Rath, Hilda A. Pickett, Murray J. Cairns, Ulf Gyllensten, Raj C. Shah, Joseph E. Powell, Paul A. James, Marie-Jo Brion, Anne M. Murray, Dmitry Degrave, Clare Puttick, Heath M. Cairns, Chantel Fitzsimmons, Paul Lacaze, Shane Husson, Rory Wolfe, John J McNeil, Vivian Francília Silva Kahl, Martin McNamara, Joshua R. Atkins, Mark Pinese, Melissa J. Green, Margo Barr, Andrew Stone, Mark Nelson, Tina Navin Cristina, Warren Kaplan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Population health research is increasingly focused on the genetic determinants of healthy ageing, but there is no public resource of whole genome sequences and phenotype data from healthy elderly individuals. Here we describe the first release of the
Autor:
Matthew A. Brown, Nicholas G. Martin, Joseph E. Powell, Jeremy Cohen, Dorrilyn Rajbhandari, Andrew Rhodes, Scott D. Gordon, Jason Meyer, Qiang Li, Elizabeth Peach, Shannon D’Urso, Gabriel Cuellar-Partida, Colin McArthur, Symen Ligthart, Simon Finfer, Balasubramanian Venkatesh, David M. Evans, John Myburgh, Erika De Guzman, Sarah E. Medland, Antje Blumenthal
Publikováno v:
Twin Research and Human Genetics, 23(4), 204-213. Cambridge University Press
Previous genetic association studies have failed to identify loci robustly associated with sepsis, and there have been no published genetic association studies or polygenic risk score analyses of patients with septic shock, despite evidence suggestin
Autor:
Stephanie T. Yerkovich, Ann Fieuw, Peter Hopkins, K.A. Sinclair, Joseph E. Powell, Paul Ford, Daniel C. Chambers, Brendan O'Sullivan
Publikováno v:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 40(1)
BACKGROUND Chronic lung allograft dysfunction (CLAD) is the leading cause of mortality in lung transplant recipients. CLAD is characterized by respiratory failure owing to the accumulation of fibrotic cells in small airways and alveoli, inducing tiss
Autor:
Cameron G. Williams, Ashraful Haque, Sarah A. Teichmann, Valentine Svensson, Megan S. F. Soon, Antiopi Varelias, Hyun Jae Lee, Lianne I. M. Lansink, Stuart D. Olver, Stacey B. Andersen, Joseph E. Powell, Jessica A. Engel, Motoko Koyama, Geoffrey R. Hill, Rachel D. Kuns
Publikováno v:
JCI Insight
Acute gastrointestinal (GI) graft-versus-host disease (GVHD) is a primary determinant of mortality after allogeneic hematopoietic stem cell transplantation (alloSCT). The condition is mediated by alloreactive donor CD4(+) T cells that differentiate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bab2552df102ec486d4bb2c21824a7
https://europepmc.org/articles/PMC7406307/
https://europepmc.org/articles/PMC7406307/
Autor:
Toby M. Maher, Brendan O'Sullivan, Peter McErlean, Adam J. Byrne, John M. Halket, Peter Saunders, Shaun Kingston, Simone A. Walker, Joseph E. Powell, Philip L. Molyneaux, Robert Gray, Clare M. Lloyd, Daniel C. Chambers, Patricia P. Ogger, Emily Calamita, Poonam Ghai, Richard J. Hewitt, Gesa J. Albers
Publikováno v:
Sci Immunol
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its role during fibrosis is unknown. Here, we reveal that itaconate is an e
Autor:
Youssef Idaghdour, Fabian J. Theis, Ahmed Mahfouz, Monique G. P. van der Wijst, Matthias Heinig, Oliver Stegle, DH de Vries, CC Hon, Gosia Trynka, Joseph E. Powell, Lude Franke, Marc Jan Bonder, P. van der Harst, Hilde E. Groot, Martijn C. Nawijn, Chun Jimmie Ye
Publikováno v:
eLife
eLife 9:e52155 (2020)
eLife, 9:52155. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 9 (2020)
eLife, 9
eLife 9:e52155 (2020)
eLife, 9:52155. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 9 (2020)
eLife, 9
In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait l
Autor:
Pieter Mestdagh, Francisco Avila Cobos, Joseph E. Powell, José Alquicira-Hernandez, Katleen De Preter
Publikováno v:
NATURE COMMUNICATIONS
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Many computational methods have been developed to infer cell type proportions from bulk transcriptomics data. However, an evaluation of the impact of data transformation, pre-processing, marker selection, cell type composition and choice of methodolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392f7060432295fbcad907cbe57cc593
https://biblio.ugent.be/publication/8680393/file/8680395
https://biblio.ugent.be/publication/8680393/file/8680395
Autor:
Alexander Holloway, Joseph E. Powell, Naomi R. Wray, Peter Smartt, Luke R. Lloyd-Jones, Jacob Gratten, Chloe X. Yap
Publikováno v:
European Journal of Human Genetics. 26:1361-1368
Trans-eQTLs have been implicated in complex traits and common diseases, but many were initially identified on the basis of having an effect in cis, and there has been no assessment of the significance of the overlap in relation to chance expectations
Autor:
Quan Nguyen, Anne Senabouth, Han Sheng Chiu, Nathan J. Palpant, Timothy J. C. Bruxner, Joseph E. Powell, Angelika N. Christ, Samuel W. Lukowski
Publikováno v:
Genome Research. 28:1053-1066
Heterogeneity of cell states represented in pluripotent cultures have not been described at the transcriptional level. Since gene expression is highly heterogeneous between cells, single-cell RNA sequencing can be used to identify how individual plur
Autor:
Grant W. Montgomery, Devin Absher, Howard W. Wiener, Joseph E. Powell, Donna K. Arnett, Elizabeth M. Kennedy, Karen N. Conneely, Allan F. McRae, Peter M. Visscher, Chloe Robins, Stella Aslibekyan, David J. Cutler
Publikováno v:
Genetics. 207:1547-1560
The evolutionary theories of mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. To better understand the relative importance of these theories, we devised a test to identify MA- and DS-