Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jonathan S. Mitchell"'
Autor:
Ben Kinnersley, Phuc H. Hoang, Fadi Hariri, Philip J. Law, Ni L Li, Matthew Scales, Tomi Pastinen, Martin Kaiser, Sara E. Dobbins, Scott Kimber, Christopher P. Wardell, David W. Johnson, Giulia Orlando, Amit Sud, Molly Went, Hartmut Goldschmidt, Niels Weinhold, Tobias Meissner, Kari Hemminki, Richard S. Houlston, Gareth J. Morgan, Amy Holroyd, Asta Försti, Jonathan S. Mitchell
Publikováno v:
Cell Reports
Cell Reports, Vol 20, Iss 11, Pp 2556-2564 (2017)
Cell Reports, Vol 20, Iss 11, Pp 2556-2564 (2017)
Summary Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences
Autor:
Kathryn A. Eaton, Eric C. Martens, Nancy N. Baxter, Jiachen Chen, Patrick D. Schloss, Bryan Schaf, Natasha Golovchenko, Lili Zhao, Jonathan S. Mitchell, Nicholas A. Pudlo, Grace Y. Chen, Sergey S. Seregin
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 733-745 (2017)
Cell Reports, Vol 19, Iss 10, p 2174 (2017)
Cell Reports, Vol 19, Iss 10, p 2174 (2017)
Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immu
Publikováno v:
Evolution. 71:633-649
Convergence is widely regarded as compelling evidence for adaptation, often being portrayed as evidence that phenotypic outcomes are predictable from ecology, overriding contingencies of history. However, repeated outcomes may be very rare unless ada
Autor:
H. Goldschmidt, Ute Hegenbart, Chiara Campo, Gareth J. Morgan, Kari Hemminki, Asta Försti, David W. Johnson, Richard S. Houlston, Jonathan S. Mitchell, Peter Hoffmann, Philip N. Hawkins, M. I. da Silva Filho, Anna Jauch, Karl-Heinz Jöckel, Stefanie Huhn, M. M. Nöthen, Iman Meziane, Giovanni Palladini, Paolo Milani, Jolanta Nickel, Stefano Landi, Niels Weinhold, Dorota Rowcieno, Ashutosh D. Wechalekar, Stefan Schönland, Giampaolo Merlini
Publikováno v:
Leukemia. 31:1735-1742
Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin light chain. AL amyloidosis and multiple myeloma (MM) originate from monoclonal gammopathy of undetermined significance. W
Publikováno v:
Methods in Ecology and Evolution. 8:37-46
Summary Understanding variation in rates of speciation and extinction – both among lineages and through time – is critical to the testing of many hypotheses about macroevolutionary processes. Bayesian Analysis of Macroevolutionary Mixtures (BAMM)
Autor:
Annette Juul Vangsted, van, Duin, M, David E. Neal, Peter Hoffmann, A Wolk, Robert J. Hamilton, Anthony J. Swerdlow, F. Wiklund, De, Ruyck, K, Paul A. Townsend, S. N. Thibodeau, Asta Försti, Esther M. John, Unnur Thorsteinsdottir, W Gregory, Niels Frost Andersen, Peter Broderick, A-K Wihlborg, Frank Claessens, Doug Easton, Kathryn L. Penney, Keith W. Muir, Jeri Kim, Jonathan S. Mitchell, Johanna Schleutker, G Cancel-Tassin, Barry S. Rosenstein, Jy Park, Hauke Thomsen, Rowan Kuiper, C West, H Gronberg, Mina Ali, CM Tangen, Obul Reddy Bandapalli, Ana Vega, Faith E. Davies, Rosalind A. Eeles, Daniel F. Gudbjartsson, Fredrick R. Schumacher, Janet L. Stanford, Paul D.P. Pharoah, Owen W. Stephens, Monique J. Roobol, Richard S. Houlston, Gudmar Thorleifsson, Christian Langer, Susan L. Neuhausen, S Chanock, G.G. Giles, Azad Razack, S Koutros, F Canzian, S Benlloch, H. Einsele, Kari Hemminki, KD Sorensen, Y-J Lu, K-T Khaw, Hareth Nahi, FC Hamdy, D Albanes, Christopher A. Haiman, Ellinor Johnsson, Amit Sud, Adam S. Kibel, Pieter Sonneveld, Florence Menegaux, Manolis Kogevinas, Nawaid Usmani, Annemiek Broyl, K. H. Jöckel, Jolanta Nickel, David W. Johnson, Aaa Olama, B.G. Nordestgaard, Amy Holroyd, Niels Weinhold, Cezary Cybulski, Sigurdur Y. Kristinsson, Radka Kaneva, Ruth C. Travis, Kari Stefansson, SI Berndt, Bowang Chen, Scott Kimber, Davor Lessel, Philip J. Law, M. M. Nöthen, Lisa A. Cannon-Albright, BE Henderson, Ni Li, Urban Gullberg, Uta Bertsch, S Weinstein, Nora Pashayan, Christiane Maier, H Brenner, Ingemar Turesson, Hardev Pandha, Thorunn Rafnar, Alison M. Dunning, Fiona M. Ross, Graham Jackson, David V. Conti, Sue A. Ingles, da, Silva, Filho, Mi, Jens Hillengass, Lisa F. Newcomb, Giulia Orlando, Brian A Walker, Teixeira, Björn Nilsson, Jenny L Donovan, Molly Went, U. H. Mellqvist, Chiara Campo, Zsofia Kote-Jarai, VL Stevens, Martin Kaiser, B-M Halvarsson, J Clements, Martin Hansson, Manuela Gago-Dominguez, EM Grindedal, Anders Waage, Julian Peto, L Mucci, Gareth J. Morgan, J Batra, H. Goldschmidt
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
PRACTICAL Consortium & Townsend, P A 2019, ' Author Correction : Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 10, no. 1, pp. 213 . https://doi.org/10.1038/s41467-018-08107-8
PRACTICAL consortium 2019, ' Author Correction : Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 10, no. 1, 213 . https://doi.org/10.1038/s41467-018-08107-8
Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
PRACTICAL Consortium & Townsend, P A 2019, ' Author Correction : Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 10, no. 1, pp. 213 . https://doi.org/10.1038/s41467-018-08107-8
PRACTICAL consortium 2019, ' Author Correction : Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma ', Nature Communications, vol. 10, no. 1, 213 . https://doi.org/10.1038/s41467-018-08107-8
Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series,
Autor:
Daniel D. Buchanan, Jussi Taipale, Lynn Martin, Tim Maughan, Susan M. Farrington, Ella Barclay, Rachel Kerr, David V. Conti, Aung Ko Win, Jeremy Peter Cheadle, Tomas Tanskanen, Shelley Idziaszczyk, Aarno Palotie, Kimmo Palin, Christopher Smith, Samuli Ripatti, Harri Rissanen, Heikki Järvinen, Mark A. Jenkins, David Jarvis, Brian F. Meyer, Jonathan S. Mitchell, Salma M. Wakil, Jaakko Kaprio, Ian Tomlinson, Noralane M. Lindor, Alexandra E. Gylfe, Laura Renkonen-Sinisalo, Eero Pukkala, Eevi Kaasinen, Richard S. Houlston, Claire Palles, Nada Al-Tassan, Richard Kaplan, Anna Lepistö, David J. Kerr, Polly A. Newcomb, Sari Tuupanen, Fred Schumacher, Antti-Pekka Sarin, Veikko Salomaa, Malcolm G. Dunlop, Lauri A. Aaltonen, Graham Casey, Johan G. Eriksson, S. Gallinger, Ulrika A. Hänninen, Pekka Jousilahti, Harry Campbell, Jan Böhm, Tatiana Cajuso, Philip J. Law, Paul Knekt, Maria Timofeeva, John L. Hopper, Johanna Kondelin, Jukka Pekka Meklin
Publikováno v:
British Journal of Cancer
Jarvis, D, Mitchell, J S, Law, P J, Palin, K, Tuupanen, S, Gylfe, A, Hänninen, U A, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A-P, Kaprio, J, Eriksson, J G, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Meklin, J-P, Al-Tassan, N A, Palles, C, Martin, L, Barclay, E, Farrington, S M, Timofeeva, M N, Meyer, B F, Wakil, S M, Campbell, H, Smith, C G, Idziaszczyk, S, Maughan, T S, Kaplan, R, Kerr, R, Kerr, D, Buchanan, D D, Win, A K, Hopper, J L, Jenkins, M A, Lindor, N M, Newcomb, P A, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Taipale, J, Aaltonen, L A, Cheadle, J P, Dunlop, M G, Tomlinson, I P & Houlston, R S 2016, ' Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer ', British Journal of Cancer . https://doi.org/10.1038/bjc.2016.188
Jarvis, D, Mitchell, J S, Law, P J, Palin, K, Tuupanen, S, Gylfe, A, Hänninen, U A, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A-P, Kaprio, J, Eriksson, J G, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Meklin, J-P, Al-Tassan, N A, Palles, C, Martin, L, Barclay, E, Farrington, S M, Timofeeva, M N, Meyer, B F, Wakil, S M, Campbell, H, Smith, C G, Idziaszczyk, S, Maughan, T S, Kaplan, R, Kerr, R, Kerr, D, Buchanan, D D, Win, A K, Hopper, J L, Jenkins, M A, Lindor, N M, Newcomb, P A, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Taipale, J, Aaltonen, L A, Cheadle, J P, Dunlop, M G, Tomlinson, I P & Houlston, R S 2016, ' Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer ', British Journal of Cancer . https://doi.org/10.1038/bjc.2016.188
Article
Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian rando
Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian rando
Autor:
Miguel Inacio da Silva Filho, Hartmut Goldschmidt, Iman Meziane, Chiara Campo, Giampaolo Merlini, Niels Weinhold, David W. Johnson, Karl-Heinz Jöckel, Kari Hemminki, Richard S. Houlston, Dorota Rowcieno, Markus M. Nöthen, Asta Försti, Philip N. Hawkins, Per Hoffmann, Jonathan S. Mitchell, Giovanni Palladini, Gareth J. Morgan, Ute Hegenbart, Stefan Schönland, Paolo Milani, Ashutosh D. Wechalekar, Stefano Landi, Jolanta Nickel, Anna Jauch, Stefanie Huhn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f6f9f24e5bf4a4b67c83fee11ae8ef
https://europepmc.org/articles/PMC5622874/
https://europepmc.org/articles/PMC5622874/
Publikováno v:
Systematic biology, 68(1), 1-18. Oxford University Press
Time-calibrated phylogenies of living species have been widely used to study the tempo and mode of species diversification. However, it is increasingly clear that inferences about species diversification - extinction rates in particular - can be unre
Autor:
Alexandre E. Grandchamp, Jaroslaw Glowacki, Robert S. Manning, John H. Maddocks, Jonathan S. Mitchell
Publikováno v:
Journal of chemical theory and computation. 13(4)
A Monte Carlo code applied to the cgDNA coarse-grain rigid-base model of B-form double-stranded DNA is used to predict a sequence-averaged persistence length of lF = 53.5 nm in the sense of Flory, and of lp = 160 bp or 53.5 nm in the sense of apparen