Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Huck-Hui Ng"'
Autor:
Tae Hwan Kwak, Chanhyeok Park, Kee-Pyo Kim, Im Joo Rhyu, Woong Sun, Kwon Ho Hong, Dong Wook Han, Hyunsoo Shawn Je, Huck-Hui Ng, Ji Eun Na, ChiHye Chung, Sai Hali, Ji Hyun Kang, Ju Hyun Lee, Junghyun Jo, Nam Kim, Jonghun Kim, Ha Kyun Ryu, Jeongwoo Kwon
Publikováno v:
STEM CELLS. 38(6):727-740
Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively immature and heterogeneous structures of the MOs hinder the translatio
Autor:
Jia-Chi Yeo, Danny Chan, Sigmar Stricker, Vivian C. W. Ng, Wilson C.W. Chan, Chen Feng, Lam Yan, Stefan Mundlos, Manuel Koch, Kathryn S.E. Cheah, Huck-Hui Ng, Xue Wang, Ben Niu, Peikai Chen
Publikováno v:
Stem Cell Reports
Summary The synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor
Publikováno v:
Annals of Clinical and Translational Neurology
The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with deve
Autor:
May Yin Lee, Zhi Han Lim, Yun Shen Chan, Feng Li, Atsushi Suzuki, Edward Kai-Hua Chow, Glenn Kunnath Bonney, John M. Asara, Alicia Stein, Matan Thangavelu Thangavelu, Yoganathan Kanagasundaram, Tan Boon Toh, Guo-Dong Lu, Joanna Z. Yeo, Hong Kee Tan, Kol Jia Yong, Siyu Wang, Justin L. Tan, Chung Yan Leong, Yock Young Dan, Chan Shuo Wu, Giridharan Periyasamy, Zi Hui Tan, Bee Hui Liu, Siming Ma, Wai Leong Tam, Huck-Hui Ng, Guo Hao Ng, Siew Bee Ng, Lissa Hooi, Nikki R. Kong, Tim Chan, Daniel G. Tenen, Li Chai, Kia Ngee Low, Mahmoud A. Bassal, Yue Wu
Publikováno v:
Gastroenterology
Background & Aims Some oncogenes encode transcription factors, but few drugs have been successfully developed to block their activity specifically in cancer cells. The transcription factor SALL4 is aberrantly expressed in solid tumor and leukemia cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870803882ebda006613d11fea7366ed
https://europepmc.org/articles/PMC7309153/
https://europepmc.org/articles/PMC7309153/
Autor:
Hongqing Liang, Jonathan Göke, Cheng Peow Tan, Huck-Hui Ng, Yun-Shen Chan, Giulia Rancati, Kevin Andrew Uy Gonzales, Iwona Szczerbinska, Cheng Kit Wong, Bertha Pei Ge Lee, Engin Cukuroglu, Muhammad Nadzim Bin Ramli
Publikováno v:
Stem Cell Reports
Summary The distinct states of pluripotency in the pre- and post-implantation embryo can be captured in vitro as naive and primed pluripotent stem cell cultures, respectively. The study and application of the naive state remains hampered, particularl
Autor:
Ka Man Yu, Yun-Shen Chan, Huck-Hui Ng, John Soon Yew Lim, Lai Ping Yaw, Chaiyaboot Ariyachet, Deniz Demircioğlu, Chwee Tat Koe, Yee Siang Lim, Einsi Lynn Soe, Hongqing Liang, Kevin Andrew Uy Gonzales, Nur Halisah Binte Jumat, Yock Young Dan, Iwona Szczerbinska, Shu Hui Koh, Zhiping Lu, Cheng Peow Tan, Asim Shabbir, Graham D. Wright, Wei-Quan Tng, Muhammad Nadzim Bin Ramli
Publikováno v:
Gastroenterology. 159:1471-1486.e12
Background & Aims There are few in vitro models for studying the 3-dimensional interactions among different liver cell types during organogenesis or disease development. We aimed to generate hepatic organoids that comprise different parenchymal liver
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
Induced pluripotent stem cells (iPSCs), which greatly circumvent the ethical issue of human embryonic stem cells (ESCs), can be induced to differentiate to dopaminergic (DA) neurons, and hence be used as a human disease model for Parkinson's disease
Autor:
Lin Yang, Huck-Hui Ng
Publikováno v:
Nature Cell Biology. 19:1010-1012
Three-dimensional brain organoid models have come into the spotlight as in vitro tools to recapitulate complex features of the brain. Four recent papers now leverage current technologies to generate new flavours of brain organoids and address aspects
Autor:
Xiaoping Han, Amy Ralston, Tapan Kumar Mistri, Guo-Cheng Yuan, Paul Robson, Daosheng Huang, Huck-Hui Ng, Ping Yuan, Janet Rossant, Mikael Huss, Luca Pinello, Lingang Sun, Junfeng Ji, Guoji Guo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
The first cellular differentiation event in mouse development leads to the formation of the blastocyst consisting of the inner cell mass (ICM) and trophectoderm (TE). The transcription factor CDX2 is required for proper TE specification, where it pro
Autor:
Huck-Hui Ng, Ng Shyh-Chang
Publikováno v:
Genesdevelopment. 31(4)
Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways