Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Runliu Wu, Daniel J. Klionsky, Daolin Tang, Xin Chen, Jingbo Li, Xinxin Song, Herbert J. Zeh, Yinghua Xu, Xiaoyan Wang, Rui Kang, Jiao Liu
Publikováno v:
Autophagy
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependen
Autor:
Enyong Dai, Leng Han, Yangchun Xie, Jiao Liu, Rui Kang, Herbert J. Zeh, Daolin Tang, Lulu Bai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Ferroptosis is a more recently recognized form of cell death that relies on iron-mediated oxidative damage. Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, i
Publikováno v:
Autophagy
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter “autophagy”) is one of the lysosome-dependent degradation systems that
Autor:
Sam C. Wang, Matthew R. Porembka, Raghav Chandra, Scott I. Reznik, Herbert J. Zeh, Neeraja Balachandar
Publikováno v:
Cancer Gene Therapy. 28:390-399
Gastric cancer is an aggressive solid-tumor malignancy with poor prognosis. The epidemiologic face of gastric cancer is changing and further insight into its heterogenous immunohistopathologic nature is needed to develop personalized therapies for sp
Autor:
Guido Kroemer, Yangchun Xie, Leng Han, Herbert J. Zeh, Enyong Dai, Jiao Liu, Rui Kang, Daniel J. Klionsky, Jing Wang, Daolin Tang
Publikováno v:
Autophagy
KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we rep
Autor:
Herbert J. Zeh, Farzad Esni, Zobeida Cruz-Monserrate, Jing Hu, Michael T. Lotze, Mairobys Socorro, George K. Gittes, Vincent Goffin, Gina M. Coudriet, Aatur D. Singhi, Mouhanned Eliliwi, Andrew V. Biankin, Peter Bailey, Angela Criscimanna, Manuj Tandon
Publikováno v:
Cancer Research. 79:5316-5327
Pancreatic ductal adenocarcinoma (PDAC) is associated with significant fibrosis. Recent findings have highlighted the profibrotic activity of tissue-resident macrophages in the pancreatic cancer microenvironment. Here, we show that neoplastic pancrea
Autor:
Michael A. Belsky, Patti Petrosko, Michael J. Becich, Steven A. Ahrendt, Matthew P. Holtzman, William A. LaFramboise, Haroon A. Choudry, Reetesh K. Pai, James F. Pingpank, Peter G. Howard, David L. Bartlett, Rajiv Dhir, Herbert J. Zeh, Apoorv Dhir
Publikováno v:
Modern Pathology. 32:1197-1209
DNA was obtained from matching micro-dissected, primary tumor cells, paired metastases, and peripheral blood mononuclear cells (germline) from patients with appendiceal mucinous neoplasms. We compared specimens from patient cohorts comprising low-gra
Autor:
Herbert J. Zeh, Ulka Sachdev, Sebastian Vogel, Xiangdong Cui, Pranav Murthy, Michael T. Lotze
Publikováno v:
Biochemical and Biophysical Research Communications. 508:614-619
Platelets play a critical role in the pathophysiology of peripheral arterial disease (PAD). The mechanisms by which muscle ischemia regulates aggregation of platelets are poorly understood. We have recently identified the Nod-like receptor nucleotide
Publikováno v:
Biochemical and Biophysical Research Communications. 506:278-283
Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme derived from Streptococcus that has been widely used for genome editing in a variety of organisms, including humans. Here, we report that exogenous Cas9 protein can elicit an
Autor:
Jill Krejdovsky, Mary Helen Black, James Ohr, Holly LaDuca, Mary Linton B. Peters, A. James Moser, Arlene Colvin, Nadine Tung, Eve Karloski, Jill S. Dolinsky, Weijing Sun, Virginia Speare, John C. Rhee, Nathan Bahary, Kim DeLeonardis, Melissa E. Hogg, Amer H. Zureikat, Kenneth H. Lee, James Cheng Yen Lee, Randall E. Brand, Beth Dudley, Allan Tsung, Herbert J. Zeh, Lindsey Stobie, Erkut Borazanci, Cynthia Lim, Emily Dalton
Publikováno v:
Cancer. 124:3520-3527
BACKGROUND The objective of this study was to investigate the prevalence of pathogenic germline variants (PGVs) in 32 cancer susceptibility genes in individuals with newly diagnosed pancreatic ductal adenocarcinoma (PDAC). A key secondary objective w