Zobrazeno 1 - 10
of 18
pro vyhledávání: '"George Kassiotis"'
Autor:
Laura Doglio, Georgina H. Cornish, George Kassiotis, Tom Lesluyes, Peter Van Loo, Anastasiya Kazachenka, Thomas Tüting, Eleonora Ottina, Veera Panova, Jan Attig, Kevin Litchfield, George R. Young, James I. MacRae, Charles Swanton, Joanna Kirkpatrick
Publikováno v:
Oncogene
The ubiquitin-proteasome system maintains protein homoeostasis, underpins the cell cycle, and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated proteolysis, remains inc
Autor:
Charlotte Fribbens, Ben Shum, James Larkin, Robert J. Wilkinson, Charles Swanton, Maddalena Cerrone, Katalin A. Wilkinson, Sonia Gandhi, Karolina Rzeniewicz, Andrew Furness, John Shon, Wenyi Xie, Kate Young, Lisa Pickering, Kim Edmonds, George Kassiotis, Naureen Starling, Susana Banerjee, Nalinie Joharatnam-Hogan, Lyra Del Rosario, Lewis Au, David K. Lau, Annika Fendler, William Gordon, Fiona Byrne, Barry Ward, Ian Chau, Ruth Harvey, Scott Shepherd, Winston A. Haynes, Samra Turajlic, Camille L. Gerard, Eleanor Carlyle
Publikováno v:
Nature Medicine
Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an ex
Autor:
Dhira Joshi, Lucy R. Marshall, Lucy R. Wedderburn, Stavroula Paraskevopoulou, Steve Gamblin, Georgina H. Cornish, Sonia Gandhi, Charles Swanton, John W. McCauley, William Bolland, Svend Kjaer, Nikhil Faulkner, Hannah Rickman, Rachel Ulferts, Philip Hobson, D.J. Benton, Laura E. McCoy, Ana Agua-Doce, Rupert Beale, Annachiara Rosa, Chloe Roustan, Nicola O’Reilly, Catherine F Houlihan, Christopher Earl, Eleni Nastouli, A.G. Wrobel, Rachael Thompson, Brigitta Stockinger, Kirsty Thomson, Catherine Moore, Bethany R. Jebson, Anna Radziszewska, Coziana Ciurtin, Andrew Riddell, Saira Hussain, Emilie Sanchez, Peter Cherepanov, Elizabeth C. Rosser, Meredyth G. Ll Wilkinson, Kevin W. Ng, Ruth Harvey, Philip A. Walker, Hannah Peckham, Judith Heaney, Gee Yen Shin, Moira J. Spyer, George Kassiotis
Publikováno v:
Science (New York, N.y.)
Science
Science
Antibodies predating infection Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that i
Autor:
Robin Schwarzer, Amanda Fisher, Snehlata Kumari, George Kassiotis, Rebecca Lane, Remzi Onur Eren, Huipeng Jiao, Manolis Pasparakis, William J. Kaiser, George R. Young, Juan Lin, Laurens Wachsmuth
Publikováno v:
Nature
The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood1–3. Z-DNA-binding protein 1 (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor that contains two Zα domains that bin
Autor:
Jerome Nicod, James I. MacRae, Amin Oomatia, Laura Cubitt, Iana Martini, Simon Caidan, Kiran Gulati, Sonia Gandhi, Luke Nightingale, Michael D. Buck, Enzo Z. Poirier, Wei-Ting Lu, Margaret Crawford, Nicola O’Reilly, Amy Strange, Michael Howell, Steve Hindmarsh, Charles Swanton, Jessica Olsen, Samra Turajlic, George Kassiotis, Paul Grant, Rupert Beale, Caetano Reis e Sousa, Mary Wu, Ming Jiang, Robert L. Goldstone, Sam Barrell, Eleni Nastouli, Rachael Instrell, Bruno Frederico, Davin Miller, Anett Rideg, Ana Cardoso, Ok-Ryul Song, Johnathan Canton, Mike Hubank, David Moore, Richard D. Byrne
Publikováno v:
Wellcome Open Research
The ongoing pandemic of SARS-CoV-2 calls for rapid and cost-effective methods to accurately identify infected individuals. The vast majority of patient samples is assessed for viral RNA presence by RT-qPCR. Our biomedical research institute, in colla
Autor:
Marta Schips, Rinako Nakagawa, Probir Chakravarty, Dinis Pedro Calado, Miriam Llorian-Sopena, Michael Meyer-Hermann, Leena Bhaw-Rosun, Amparo Toboso-Navasa, George Kassiotis, Abdul Sesay, George R. Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
United Kingdom
United States
Proceedings of the National Academy of Sciences
United Kingdom
United States
Proceedings of the National Academy of Sciences
Significance Light zone (LZ) B cells are selected in germinal centers (GCs) in a cMyc-dependent manner, before dark zone (DZ) migration. Antigen affinity of B cells is enhanced during GC responses, and some differentiate into plasmablasts or memory B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324884fd15e41e7bb5e55c4fbb7cd61
https://hdl.handle.net/10033/622718
https://hdl.handle.net/10033/622718
Autor:
Spyros I. Papamichos, Kevin W. Ng, George R. Young, Eleonora Ottina, Jan Attig, George Kassiotis, Ioannis Kotsianidis
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Immune regulation is a finely balanced process of positive and negative signals. PD-L1 and its receptor PD-1 are critical regulators of autoimmune, antiviral and antitumoural T cell responses. Although the function of its predominant membrane-bound f
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
CD4+ T cell differentiation is influenced by a plethora of intrinsic and extrinsic factors, providing the immune system with the ability to tailor its response according to specific stimuli. Indeed, different classes of pathogens may induce a distinc
Autor:
Eleonora Ottina, Thomas Tüting, Urszula Eksmond, George R. Young, Juliette Roels, Prisca Levy, Dinis Pedro Calado, George Kassiotis, Jonathan P. Stoye, Julia Merkenschlager
Publikováno v:
Cancer immunology research. 6(11)
Mouse models have been instrumental in establishing fundamental principles of cancer initiation and progression and continue to be invaluable in the discovery and further development of cancer therapies. Nevertheless, important aspects of human disea
Autor:
Muriel Moser, Isabel Vogel, George Kassiotis, Adrien Galuppo, Martina Fontaine, Christine Decaestecker, Yves-Remi Van Eycke, Oberdan Leo, Yousra Ajouaou
To analyze the potential role of Tregs in controlling the TCR repertoire breadth to a non‐self‐antigen, a TCRβ transgenic mouse model (EF4.1) expressing a limited, yet polyclonal naive T‐cell repertoire was used. The response of EF4.1 mice to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c6b86aa47b2e0feb8f4de5674acfbe
https://europepmc.org/articles/PMC5793804/
https://europepmc.org/articles/PMC5793804/