Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ge, Fei"'
Publikováno v:
Drug Discovery Today. 25:2006-2011
Organic synthesis is a vital process that is a mainstay of drug discovery. However, traditional manual-based approaches to organic synthesis might not be economical, especially in a research environment where budgets are increasingly restricted and t
Publikováno v:
Journal of Cellular and Molecular Medicine. 24:14086-14098
Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory disease with uncertain aetiology. Exosomes are nanosized particles with biological capacities. Here, we aimed to study the effects of T cell-derived exosomes (T-exos) on the pathogene
Autor:
Kai Lu Zhang, Yan Ming Fang, Ge-Fei Hao, Jianhua Zhang, Fu-Yuan Zhu, Tian Yuan, Feng Yang, Caie Wu, Mo-Xian Chen, Zhen Feng, Di Zhang, Jing-Fang Yang
Publikováno v:
BMC Plant Biology, Vol 20, Iss 1, Pp 1-20 (2020)
BMC Plant Biology
BMC Plant Biology
Background Among eukaryotic organisms, alternative splicing is an important process that can generate multiple transcripts from one same precursor messenger RNA, which greatly increase transcriptome and proteome diversity. This process is carried out
Autor:
Jing-Fang Yang, Debatosh Das, Lei Dai, Yan-Ming Fang, Mo-Xian Chen, Yuan Tian, Kai-Lu Zhang, Bei Gao, Jianhua Zhang, Guang-Fu Yang, Tao Fan, Ge-Fei Hao, Fu-Yuan Zhu
Publikováno v:
The Plant Journal. 103:357-378
Intron-containing genes have the ability to generate multiple transcript isoforms by splicing, thereby greatly expanding the eukaryotic transcriptome and proteome. In eukaryotic cells, precursor mRNA (pre-mRNA) splicing is performed by a mega-macromo
Publikováno v:
Drug Discovery Today. 25:248-258
Undesirable pharmacokinetic (PK) properties or unacceptable toxicity are the main causes of the failure of drug candidates at the clinical trial stage. Since the concept of drug-likeness was first proposed, it has become an important consideration in
Autor:
Jian-Ren Liu, Yi-Sheng Liu, Yue Hu, Changchun Lin, Ge-Fei Li, Mei-Ting Zhuang, Rong Zhao, Jingjing Su, Yan-Hui Shi, Xin-Wei He
Publikováno v:
Atherosclerosis. 289:36-43
Background and aims Circulating microRNAs (miRNAs) have recently emerged as promising biomarkers for acute ischaemic stroke (AIS). However, the expression profiles of miRNAs in AIS patients receiving intravenous thrombolysis, and their associations w
Autor:
Bei Gao, Jing-Fang Yang, Li Jun Fu, Moxian Chen, Di Zhang, Jianhua Zhang, Guang-Fu Yang, Ge-Fei Hao, Tie Yuan Liu
Publikováno v:
Planta. 249:1997-2014
The work offers a comprehensive evaluation on the phylogenetics and conservation of splicing patterns of the plant SPF30 splicing factor gene family. In eukaryotes, one pre-mRNA can generate multiple mRNA transcripts by alternative splicing (AS), whi
Autor:
Jing-Fang Yang, Qi Juan Hu, Guang-Fu Yang, Yuan Tian, Ge-Fei Hao, Bei Gao, Yinggao Liu, Zhi Yong Dian, H. H.K. Achala, Di Zhang, Moxian Chen, Jianhua Zhang
Publikováno v:
Planta. 249:583-600
This study systematically identifies plant SYF2/NTC31/p29 genes from 62 plant species by a combinatory bioinformatics approach, revealing the importance of this gene family in phylogenetics, duplication, transcriptional, and post-transcriptional regu
Autor:
Jian Qu, Ge-Fei He, Xin-Qi Teng, Liang-Jun Ye, Qiong Lu, Haihong Zhu, Qiang Qu, Tingting Qi, Guohua Li
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine
Frontiers in Medicine
Objective: The emergence of carbapenem-resistant gram-negative bacteria (CR-GNB) has brought great challenges to clinical anti-infection treatment around the world. Polymyxins are often considered as the last line of defense in the treatment of CR-GN
Publikováno v:
Drug Discovery Today
The infectious disease Coronavirus 2019 (COVID-19) continues to cause a global pandemic and, thus, the need for effective therapeutics remains urgent. Global research targeting COVID-19 treatments has produced numerous therapy-related data and establ