Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dipanjan Chowdhury"'
Autor:
Ira Winer, Andrea E. Wahner Hendrickson, Roxanne Quinn, Russell J. Schilder, Alan D. D'Andrea, Alexander B. Olawaiye, Elise C. Kohn, Susan Schumer, Su Chun Cheng, Lisa Barroilhet, Ursula A. Matulonis, Anniina Färkkilä, Michael T. McHale, Dipanjan Chowdhury, Elizabeth K. Lee, L. Austin Doyle, Linda R. Duska, Jennifer Curtis, Siqing Fu, Brittany Bowes, Geoffrey I. Shapiro, Marta A. Crispens, Panagiotis A. Konstantinopoulos, Richard T. Penson
Publikováno v:
Lancet Oncol
Summary Background High-grade serous ovarian cancers show increased replication stress, rendering cells vulnerable to ATR inhibition because of near universal loss of the G1/S checkpoint (through deleterious TP53 mutations), premature S phase entry (
Autor:
Yinghui Zhou, Bose Kochupurakkal, Anniina Färkkilä, Dipanjan Chowdhury, Bruce J. Dezube, Geoffrey I. Shapiro, Huy V. Nguyen, Scott J. Rodig, Alan D. D'Andrea, Pamela N. Munster, Ursula A. Matulonis, Connor A. Jacobson, Sandro Santagata, Yu-An Chen, Ana Lako, Clarence Yapp, Panagiotis A. Konstantinopoulos, Zoltan Maliga, Elizabeth M. Swisher, Doga Gulhan, Julie R. Graham, Denis Schapiro, Elizabeth P. Garcia, Peter J. Park, Julia Casado, Sampsa Hautaniemi, Peter K. Sorger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Combined PARP and immune checkpoint inhibition has yielded encouraging results in ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling and highly multiplexed single-cell imaging on tumor samples from patients en
Publikováno v:
Translational Research. 201:71-83
Due to tremendous technological advances, radiation oncologists are now capable of personalized treatment plans and deliver the dose in a highly precise manner. However, a crucial challenge is how to escalate radiation doses to cancer cells while red
Autor:
Lorelei A. Mucci, Andreas Pettersson, Travis Gerke, Stephen P. Finn, Konrad H. Stopsack, Meir J. Stampfer, Massimo Loda, Michelangelo Fiorentino, Ericka M. Ebot, Dipanjan Chowdhury, Philip W. Kantoff, Piotr Zareba, Richard Flavin
Publikováno v:
Carcinogenesis
DNA repair genes are commonly altered in metastatic prostate cancer, but BRCA1 mutations are rare. Preliminary studies suggest that higher tumor expression of the BRCA1 protein may be associated with worse prognosis. We undertook a prospective study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c182c992c9073da0f3344951e69943
https://europepmc.org/articles/PMC7359768/
https://europepmc.org/articles/PMC7359768/
Autor:
Guillaume Adelmant, Kavita Shah, Peter Sicinski, Shakti Ranjan Satapathy, Sanket S. Acharya, Dipanjan Chowdhury, Keith Viccaro, Kumar Nikhil, Katherine N. Choe, Amarnath Natarajan, Sandeep Rana, Xiaofeng Zheng, Jarrod A. Marto, Samanta Sharma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of
Autor:
Pascal Drané, Anchal Sharma, Yizhou Joseph He, Daryl A. Ronato, Chunyu Yang, Jie Bian, Alan D. D'Andrea, Jessica L. Moore, Subhajyoti De, Panagiotis A. Konstantinopoulos, Khyati Meghani, Alexandre Detappe, Joshi Niraj, Marie-Christine Caron, John G. Doench, Dipanjan Chowdhury, David E. Root, Gaëlle Legube, Jean-Yves Masson
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Nature, Nature Publishing Group, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Limited DNA end resection is the key to impaired homologous recombination in BRCA1-mutant cancer cells. Here, using a loss-of-function CRISPR screen, we identify DYNLL1 as an inhibitor of DNA end resection. The loss of DYNLL1 enables DNA end resectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b966e35510cb20242f24be01764ace
https://europepmc.org/articles/PMC7155769/
https://europepmc.org/articles/PMC7155769/
Autor:
Panagiotis A. Konstantinopoulos, Karin K. Shih, Young Eun Choi, Marie Eve Brault, Ronny Drapkin, David M. Weinstock, Tovah A. Day, Dipanjan Chowdhury, Khyati Meghani, Fanny Dao, Douglas A. Levine, Lucas Leclerc, Kevin M. Elias, Yizhou Joseph He, Ursula A. Matulonis
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 429-439 (2016)
SummaryHigh-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an under
Autor:
Catarina Oliveira, Dipanjan Chowdhury, Nishita Parnandi, J. Ross Chapman, James R. Thompson, Benoît Bragantini, Gaofeng Cui, Maria Victoria Botuyan, Debiao Zhao, Alexandre Detappe, Shweta Chaubey, Georges Mer, Pascal Drané, Marie Eve Brault
Dynamic protein interaction networks such as DNA double-strand break (DSB) signaling are modulated by post-translational modifications (PTMs). The DNA repair factor 53BP1 is a rare example of a protein whose PTM binding function can be switched on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fe4c237e6413f1742a0c5b8650b051
https://doi.org/10.1038/s41594-018-0083-z
https://doi.org/10.1038/s41594-018-0083-z
Autor:
Ioannis S. Pateras, Maria Chiourea, Dipanjan Chowdhury, Ioanna Mourkioti, Wojciech Fendler, Sophia V. Rizou, Aristides G. Eliopoulos, Sentiljana Gumeni, Eleni Paparouna, Ioannis P. Trougakos, Eric O’Neill, Christos P. Zampetidis, Vassilis G. Gorgoulis, Jiri Bartek, Eirini-Stavroula Komseli, Dafni-Eleftheria Pefani, Sarantis Gagos, Konrad Stawiski, Alexander Polyzos, Thorbjørn Krejsgaard, Fani-Marlen Roumelioti
Publikováno v:
Komseli, E, Pateras, I S, Krejsgaard, T, Stawiski, K, Rizou, S V, Polyzos, A, Roumelioti, F, Chiourea, M, Mourkioti, I, Paparouna, E, Zampetidis, C P, Gumeni, S, Trougakos, I P, Pefani, D, O’neill, E, Gagos, S, Eliopoulos, A G, Fendler, W, Chowdhury, D, Bartek, J & Gorgoulis, V G 2018, ' A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence ', BMC Genomics, vol. 19, no. 1 . https://doi.org/10.1186/s12864-017-4375-1
BMC Genomics, Vol 19, Iss 1, Pp 1-22 (2018)
BMC Genomics
Komseli, E S, Pateras, I S, Krejsgaard, T, Stawiski, K, Rizou, S V, Polyzos, A, Roumelioti, F M, Chiourea, M, Mourkioti, I, Paparouna, E, Zampetidis, C P, Gumeni, S, Trougakos, I P, Pefani, D E, O'Neill, E, Gagos, S, Eliopoulos, A G, Fendler, W, Chowdhury, D, Bartek, J & Gorgoulis, V G 2018, ' A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence ', BMC Genomics, vol. 19, no. 1, 37 . https://doi.org/10.1186/s12864-017-4375-1
BMC Genomics, Vol 19, Iss 1, Pp 1-22 (2018)
BMC Genomics
Komseli, E S, Pateras, I S, Krejsgaard, T, Stawiski, K, Rizou, S V, Polyzos, A, Roumelioti, F M, Chiourea, M, Mourkioti, I, Paparouna, E, Zampetidis, C P, Gumeni, S, Trougakos, I P, Pefani, D E, O'Neill, E, Gagos, S, Eliopoulos, A G, Fendler, W, Chowdhury, D, Bartek, J & Gorgoulis, V G 2018, ' A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence ', BMC Genomics, vol. 19, no. 1, 37 . https://doi.org/10.1186/s12864-017-4375-1
Background Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for ca
Autor:
Luca Scorrano, George Pappas, Jiri Bartek, Vassilis L. Souliotis, Nicholas E. Geacintov, Umakanta Swain, Athanassios Kotsinas, Alexandros G. Georgakilas, Panagiotis Galanos, Dipanjan Chowdhury, Christina Glytsou, Ioannis S. Pateras, Zvi Livneh, Vassilis G. Gorgoulis, Zoi Lygerou, Jiri Lukas, Claudia Lukas, Alexander Polyzos, Claus Storgaard Sørensen, Nickolaos N. Giakoumakis, Ioanna Svolaki
Publikováno v:
Genome Biology
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Galanos, P, Pappas, G, Polyzos, A, Kotsinas, A, Svolaki, I, Giakoumakis, N N, Glytsou, C, Pateras, I S, Swain, U, Souliotis, V L, Georgakilas, A G, Geacintov, N, Scorrano, L, Lukas, C, Lukas, J, Livneh, Z, Lygerou, Z, Chowdhury, D, Sørensen, C S, Bartek, J & Gorgoulis, V G 2018, ' Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability ', Genome Biology (Online Edition), vol. 19, 37, pp. 1-18 . https://doi.org/10.1186/s13059-018-1401-9
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Galanos, P, Pappas, G, Polyzos, A, Kotsinas, A, Svolaki, I, Giakoumakis, N N, Glytsou, C, Pateras, I S, Swain, U, Souliotis, V L, Georgakilas, A G, Geacintov, N, Scorrano, L, Lukas, C, Lukas, J, Livneh, Z, Lygerou, Z, Chowdhury, D, Sørensen, C S, Bartek, J & Gorgoulis, V G 2018, ' Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability ', Genome Biology (Online Edition), vol. 19, 37, pp. 1-18 . https://doi.org/10.1186/s13059-018-1401-9
Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p2