Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David L. Huso"'
Autor:
Robert A. Anders, Sepideh Besharati, Xinqun Wu, Franck Housseau, Payam Fathi, Jawara Allen, Laura Jenkins, Shaoguang Wu, David L. Huso, Amanda E. Mackenzie, Ben Park, Cynthia L. Sears, Graeme Milligan, Annemarie Boleij, William Brian Dalton
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, 4
Communications Biology
Communications Biology, 4, 1
Communications Biology, 4
Communications Biology
Communications Biology, 4, 1
G protein-coupled receptor (GPR)35 is highly expressed in the gastro-intestinal tract, predominantly in colon epithelial cells (CEC), and has been associated with inflammatory bowel diseases (IBD), suggesting a role in gastrointestinal inflammation.
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Autor:
John M. Craig, Shaoguang Wu, Christina E. DeStefano Shields, Xinqun Wu, Robert A. Anders, Christine M. Dejea, Rahwa Taddese, Hao Wang, Abby L. Geis, David L. Huso, Drew M. Pardoll, Francis M. Giardiello, Elizabeth C. Wick, Annemarie Boleij, Franck Housseau, Payam Fathi, Elizabeth M. Hechenbleikner, Cynthia L. Sears
Publikováno v:
Science, 359, 6375, pp. 592-597
Science, 359, 592-597
Science, 359, 592-597
Biofilms provide refuge for cancerous bacteria Familial adenomatous polyposis (FAP) causes benign polyps along the colon. If left untreated, FAP leads to a high incidence of colon cancer. To understand how polyps influence tumor formation, Dejea et a
Publikováno v:
Blood. 131:323-327
The stromal signals that promote B lymphopoiesis remain poorly understood. Hedgehog (Hh) signaling promotes B lymphopoiesis in a non-cell-autonomous fashion in vitro, and depletion of the Hh effector Smoothened (Smo) from stromal cells is associated
Autor:
Alfred Morgenstern, Zhe Zhang, Takahiro Yoshida, Hong Song, Sunju Park, Han Liangfeng, Charles Zhu, Saraswati Sukumar, Frank Bruchertseifer, Kideok Jin, George Sgouros, David L. Huso
Publikováno v:
Oncotarget
The standard treatment for ductal carcinoma in situ (DCIS) of the breast is surgical resection, followed by radiation. Here, we tested localized therapy of DCIS in mice using the immunoconjugate 225Ac linked-trastuzumab delivered through the intraduc
Autor:
Liangfeng Han, Helen Sadik, Yolanda M.N. Foster, Duojia Pan, Angela Brodie, Zhe Zhang, Syed Z. Ali, Peter Ordentlich, David L. Huso, Christina Adams, Roisin M. Connolly, Soonweng Cho, Vered Stearns, Nguyen Nguyen, Preethi Korangath, Kideok Jin, Saraswati Sukumar, Xian C. Zhou, Qian Chen, Vanessa F. Merino
Publikováno v:
Cancer Research. 76:2013-2024
Efforts to induce the differentiation of cancer stem cells through treatment with all-trans retinoic acid (ATRA) have yielded limited success, partially due to the epigenetic silencing of the retinoic acid receptor (RAR)-β. The histone deacetylase i
Autor:
Michael Koo, James Turkson, David L. Huso, Tait Huso, Patrick T. Gunning, Lingling Xian, Guosheng Liu, Brent D. G. Page, Amy Belton, Li Z. Luo, Linda M.S. Resar
Publikováno v:
Leukemia & Lymphoma. 57:2681-2684
Despite dramatic improvements in treatment and survival, acute lymphoid malignancies remain the leading cause of death in children with cancer and a highly lethal malignancy in adults.[1] Acute lym...
Autor:
Venkata S. Pendyala, James J. Potter, Lahari Koganti, Svetlana Lutsenko, David L. Huso, Uta Merle, Joseph A. Hankin, Esteban Mezey, James P. Hamilton, Abigael Muchenditsi, Nan Yang, Dominik Huster, Christopher Mangels, Robert C. Murphy
Publikováno v:
Hepatology. 63:1828-1841
UNLABELLED Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper-transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is based on copper chelation, which decreases the manifestatio
Autor:
Leslie Cope, Linda M.S. Resar, Wenyong Kuang, Lingling Xian, David L. Huso, Andrew J. Ewald, Stefania Senger, Amy Belton, Tait Huso, Alessio Fasano, Dan Georgess, Yu Ting Chang, Xiaoyan Zhang, Qihua Gu
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and p
Autor:
Joel S. Benjamin, Genay Pilarowski, Kasper D. Hansen, Li Zhang, David L. Huso, Loyal A. Goff, Hans T. Bjornsson, Giovanni A. Carosso, Hilary J. Vernon
Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438bd1312dca26950ac3111614b4f935
https://europepmc.org/articles/PMC5224378/
https://europepmc.org/articles/PMC5224378/
Autor:
Herbert H. Hill, Linda Resar, David L. Huso, Lingling Xian, Leslie Cope, Michael Williams, Raymond Reeves, David R. Gang, Tait Huso, Jeong-Jin Park, William F. Siems
Publikováno v:
Journal of proteome research. 15(12)
Because colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, more accessible screening tests are urgently needed to identify early stage lesions. We hypothesized that highly sensitive, metabolic profile analysis of stool sam