Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Daniel T. Meehan"'
Autor:
Brianna Dufek, Edward Doyle, Michael Anne Gratton, Ross Coenen, Daniel T. Meehan, Brendan J Smyth, Jacob Madison, Gina Samuelson, Kevin Wilhelm, Dominic Cosgrove, Grady Phillips, Duane Delimont
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237907 (2020)
PLoS ONE
PLoS ONE
Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracel
Autor:
Grady Phillips, Daniel T. Meehan, Marisa Zallocchi, Michael Anne Gratton, Duane Delimont, Dominic Cosgrove, Brianna Dufek
Publikováno v:
Hearing Research. 341:100-108
Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation
Autor:
Shiguang Liu, Duane Delimont, Brianna Dufek, Michael Anne Gratton, Linda Cheung, Wenping Song, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove
Publikováno v:
Kidney International. 90:300-310
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillar
Autor:
Gina Samuelson, Duane Delimont, Michael Anne Gratton, Flint A Boettcher, Daniel T. Meehan, Xiourui Shi, Jacob Madison, Brianna Dufek, Dominic Cosgrove, Vincent Trosky
Publikováno v:
Hear Res
In 129 Sv autosomal Alport mice, the strial capillary basement membranes (SCBMs) progressively thicken between 5 and 9 weeks of age resulting in a hypoxic microenvironment with metabolic stress and induction of pro-inflammatory cytokines and chemokin
Autor:
Grady Phillips, Michael Anne Gratton, Duane Delimont, Deidre A. MacKenna, Gretchen Bain, Dominic Cosgrove, Daniel T. Meehan, Brianna Dufek, Michael Hartnett, Gina Samuelson
Publikováno v:
Kidney Int
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize