Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chihiro Morishima"'
Autor:
Jack O. Egan, Jeffrey S. Miller, Ann W. Silk, Martin A. Cheever, Hing C. Wong, Sylvia Lee, Steven P. Fling, Peter R. Rhode, Chihiro Morishima, Shernan G. Holtan, Andreanne M. Lacroix, Kim Margolin, Judith C Kaiser, Monica Brown Jones, Marc S. Ernstoff, Amy Rock, Vamsidhar Velcheti
Publikováno v:
Clinical Cancer Research. 24:5552-5561
Purpose: IL15 induces the activation and proliferation of natural killer (NK) and memory CD8+ T cells and has preclinical antitumor activity. Given the superior activity and favorable kinetics of ALT-803 (IL15N72D:IL15RαSu/IgG1 Fc complex) over reco
Autor:
Andrew Bryan, Patrick C. Mathias, Susan L. Fink, Mark H. Wener, Anu Chaudhary, Keith R. Jerome, Meghan A Gattuso, Alexander L. Greninger, Gregory Pepper, Chihiro Morishima
Publikováno v:
Open Forum Infectious Diseases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load on admission was associated with a significantly increased 30-day mortality (odds ratio [OR], 4.20; 95% CI, 1.62–10.86), and anti-SARS-CoV-2 nucleocapisid IgG seropositivity on
Autor:
Michael R. Holbrook, Andrew Bryan, Christopher L. McClurkan, David M. Koelle, Anna Wald, Mark H. Wener, Lichen Jing, Janie Liang, Susan L. Fink, Stacy Selke, Chihiro Morishima, Elena Postnikova, Sarah A. McGuffin, Danniel Zamora, Adrienne E Shapiro, Marie K. Das, Anu Chaudhary, Alexander L. Greninger, Steven Mazur, Terry Gernsheimer, Vladimir V. Lukin, Jim Boonyaratanakornkit, Robin Gross, Victoria L. Campbell, Keith R. Jerome
Publikováno v:
The Journal of clinical investigation. 131(3)
BACKGROUNDSARS-CoV-2-specific antibodies may protect from reinfection and disease, providing rationale for administration of plasma containing SARS-CoV-2-neutralizing antibodies (nAbs) as a treatment for COVID-19. Clinical factors and laboratory assa
Autor:
Davey M. Smith, Jeffrey I. Cohen, Stephen A. Rawlings, Chihiro Morishima, Jeffrey R Strich, Peter D. Burbelo, Richard T. Davey, Sanchita Das, Daniel S. Chertow, Francis X. Riedo
Publikováno v:
The Journal of Infectious Diseases
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is associated with respiratory-related disease and death. Assays to detect virus-specific antibodies are important to understan
Autor:
Judith C Kaiser, Douglas G. McNeel, Howard Streicher, Manish R. Patel, Holbrook E Kohrt, Mary L. Disis, Martin A. Cheever, Steven P. Creekmore, Jeffrey S. Miller, Heather A. Wakelee, Chihiro Morishima, Paul M. Sondel, Kevin C. Conlon, Thomas A. Waldmann, John A. Thompson
Publikováno v:
Clinical Cancer Research. 24:1525-1535
Purpose: Preclinical data established IL15 as a homeostatic factor and powerful stimulator of NK and CD8+ T-cell function, the basis for clinical testing.Experimental Design: A first-in-human outpatient phase I dose escalation trial of subcutaneous (
Autor:
Deborah I. Ritter, Ata S. Moshiri, Mark H. Wener, Masaoki Kawasumi, Jayasri G. Iyer, Aaron Lisberg, Erica S. Tarabadkar, William T. Simonson, Lola Mudgistratova, C. Lewis, Chihiro Morishima, Joseph J. Carter, Kelly G. Paulson, Astrid Blom, Paul Nghiem, Denise A. Galloway, Kathleen Hutchinson, Shailender Bhatia, Mary W. Redman
Publikováno v:
Cancer. 123:1464-1474
BACKGROUND Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antig
Autor:
Chihiro Morishima, Lei Yu, Minjun C. Apodaca, Amy Wright, William P. Harris, Raymond S. Yeung, Angela M. Riggins
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Background Myeloid-derived suppressor cells (MDSC) have been found to play an important role in limiting immune responses in cancer. Higher circulating MDSC levels have been associated with greater tumor burden, poorer response to immunotherapy, and
Autor:
Carolyn Zanis, Gaelen K. Dwyer, Brenna C. Simons, Philip R. Spradling, Tammy L. Choromanski, Mary Snowball, Minjun C. Apodaca, Chihiro Morishima, Samantha Case, Cindy Knall, Michael G. Bruce, Dana J. T. Bruden, Susan Negus, Hazel D. Brogdon, Brian J. McMahon
Publikováno v:
Journal of Infectious Diseases. 214:273-280
Background. Long-lasting protection resulting from hepatitis B vaccine, despite loss of antibody against hepatitis B virus (HBV) surface antigen (anti-HBs), is undetermined. Methods. We recruited persons from a cohort vaccinated with plasma-derived h
Autor:
Laura Q.M. Chow, Leslie N. Anderson, Mary L. Disis, Robert M. Hershberg, James Kyle Bryan, Keith D. Eaton, Bernardo H. L. Goulart, Kristi Manjarrez, Christina S. Baik, Renato G. Martins, Chihiro Morishima, Gregory N. Dietsch
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(10)
Purpose: As Toll-like receptors (TLR) are key mediators of immune responses, TLR agonists may be important for augmenting the efficacy of therapies for squamous cell carcinoma of the head and neck (SCCHN). Motolimod (VTX-2337), a selective small-mole
Publikováno v:
The British journal of nutrition. 115(2)
Dietary cholesterol induces hepatic inflammation and fibrosis in animals. We aimed to determine whether dietary cholesterol affects liver-related mortality in hepatitis C virus (HCV)-infected patients. We performed a retrospective cohort study using