Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anna Ciotkowska"'
Autor:
Ruixiao Wang, Alexander Tamalunas, Christian G. Stief, Beata Rutz, Bingsheng Li, Cora Sauckel, Ru Huang, Anna Ciotkowska, Martin Hennenberg, Christian Gratzke
Publikováno v:
Life sciences. 281
Aims Medical treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia is characterized by an unfavorable balance between limited efficacy and pronounced side effects. We recently reported, that thalidomide reduces prostate
Autor:
Annika Herlemann, Christian Gratzke, Christian G. Stief, Beata Rutz, Raphaela Waidelich, Paul Kuppermann, Martin Hennenberg, Yiming Wang, Alexander Tamalunas, Anna Ciotkowska, Bingsheng Li, Xiaolong Wang, Qingfeng Yu, Frank Strittmatter, Ruixiao Wang
Publikováno v:
J Biol Chem
Voiding symptoms in benign prostatic hyperplasia (BPH) are driven by prostate smooth muscle contraction and prostate growth. Smooth muscle contraction in the prostate and other organs critically depends on activation of the small monomeric GTPase Rho
Autor:
Cora Sauckel, Ru Huang, Ruixiao Wang, Bingsheng Li, Martin Hennenberg, Anna Ciotkowska, Christian Gratzke, Alexander Tamalunas, Christian G. Stief, Beata Rutz
Publikováno v:
The ProstateREFERENCES. 81(7)
Background Medical treatment in benign prostatic hyperplasia targets prostate size to prevent disease progression, complications, and surgery, and prostate smooth muscle tone for rapid relief of lower urinary tract symptoms. Combination therapies are
Autor:
Beata Rutz, Qingfeng Yu, Bingsheng Li, Ruixiao Wang, Martin Hennenberg, Christian G. Stief, Anna Ciotkowska, Xiaolong Wang, Yiming Wang
Publikováno v:
Life sciences. 261
Aims RacGTPase-mediated proliferation and smooth muscle contraction in the lower urinary tract has been recently suggested and may offer putative targets for treamtment of lower urinary tract symptoms. However, RacGTPase function for proliferation of
Autor:
Annika Herlemann, Xiaolong Wang, Christian Sterr, Beata Rutz, Martin Hennenberg, Anna Ciotkowska, Christian Gratzke, Christian G. Stief, Frank Strittmatter, Qingfeng Yu, Yiming Wang
Publikováno v:
British Journal of Pharmacology. 175:2077-2096
LUTS refer to a group of urological symptoms that are caused by multifactorial aetiology. The prevalence of LUTS increases with age, and will thereby lead to heavy economic burden for the society. In men with benign prostate hyperplasia, increased sm
Autor:
Beata Rutz, Yiming Wang, Alexander Tamalunas, Christian G. Stief, Melanie Schott, Annika Herlemann, Christian Gratzke, Frank Strittmatter, Anna Ciotkowska, Patrick Keller, Martin Hennenberg, Raphaela Waidelich, Qingfeng Yu
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F47-F57
Prostate smooth muscle contraction is critical for etiology and treatment of male lower urinary tract symptoms (LUTS) and is promoted by small monomeric GTPases (RhoA and Rac). GTPases may be activated by guanosine nucleotide exchange factors (GEFs).
Autor:
Christian Gratzke, Alice C. Acevedo, Martin Hennenberg, Frank Strittmatter, Anna Ciotkowska, Beata Rutz, Annika Herlemann, Christian G. Stief, Nicolas Wiemer, Qingfeng Yu, Yiming Wang, Aysenur Kan, Alexander Tamalunas
Publikováno v:
The Prostate. 77:697-707
BACKGROUND. Lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia may be caused by prostate smooth muscle contraction. Although alpha(1)-blockers may improve symptoms by prostate smooth muscle relaxation, their efficacy is li
Autor:
Martin Hennenberg, Beata Rutz, Sophie Janich, Anna Ciotkowska, Christian Gratzke, Frank Strittmatter, Christian G. Stief, Chunxiao Liu, Alexander Tamalunas, Annika Herlemann, Yiming Wang, Raphaela Waidelich
Publikováno v:
British Journal of Pharmacology. 173:3342-3358
Background and Purpose In benign prostatic hyperplasia, increased prostate smooth muscle tone and prostate volume may contribute alone or together to urethral obstruction and voiding symptoms. Consequently, connections between smooth muscle tone and
Autor:
Beata Rutz, Frank Strittmatter, Christian G. Stief, Martin Hennenberg, Christian Gratzke, Bingsheng Li, Xiaolong Wang, Chunxiao Liu, Annika Herlemann, Yiming Wang, Alexander Tamalunas, Christian Sterr, Qingfeng Yu, Anna Ciotkowska, Raphaela Waidelich
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Epidemiologic studies revealed a context between lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and metabolic syndrome. However, molecular mechanisms underlying this relationship are largely unknown. Prostate enl
Autor:
Beata Rutz, Alexander Tamalunas, Raphaela Waidelich, Martin Hennenberg, Ruixiao Wang, Maya Ridinger, Xiaolong Wang, Mark G. Erlander, Christian G. Stief, Anna Ciotkowska, Bingsheng Li
Publikováno v:
European Journal of Pharmacology. 873:172985
Prostate smooth muscle contraction and prostate enlargement contribute to lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Recent evidence demonstrated that inhibitors for polo-like kinases (PLKs) inhibit smooth muscle contrac