Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andrew J. Gifford"'
Autor:
Loretta Lau, Mark J. Cowley, Paul G Ekert, Michael Rodriguez, Chelsea Mayoh, Richard J. Cohn, Velimir Gayevskiy, Marie Wong, Andrew J. Gifford, Mark Pinese, Amit Kumar, Mark Reynolds, Michelle Haber, David S. Ziegler, Vanessa Tyrrell, Michael C. Cox, Glenn M. Marshall, Dong-Anh Khuong-Quang, Emily Mould, Maria Tsoli
Publikováno v:
British Journal of Cancer
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the fir
Autor:
Mustafa Syed, Emmy D.G. Fleuren, Chelsea Mayoh, Velimir Gayevskiy, Richard B. Lock, Toby Trahair, Emilie E. Wilkie, Mark Pinese, Heather Tapp, Michelle Haber, Amit Kumar, Inigo Martincorena, Jonathan Baber, Alexandra Sherstyuk, Dylan Grebert-Wade, Rachel Bowen-James, Tracey A. O'Brien, Frank Alvaro, Marie Wong, Andrew J. Gifford, Luciano Dalla-Pozza, David S. Ziegler, Paul Wood, Murray D. Norris, Glenn M. Marshall, Marie Gauthier, David Thomas, Peter Priestley, Mark J. Cowley, Paul G Ekert, Nicholas G. Gottardo, M. Emmy M. Dolman, Vanessa Tyrrell, Dong Anh Khuong-Quang, Geoffry B. McCowage, Andrew S. Moore, Katherine M. Tucker, Emily Mould, Paulette Barahona, Judy Kirk, Loretta Lau, Seong Lin Khaw, Federico Abascal, Meera Warby, Elodie Manouvrier, Patricia Sullivan, Noemi A. Bolanos, Patrick Strong, Jordan R. Hansford
Publikováno v:
Nature medicine. 26(11)
The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from hi
Autor:
Andrei V. Krivtsov, Richard B. Lock, Kenneth N. Ross, Florian Perner, Sarah Naomi Olsen, Tara Pritchard, David A. Claremon, Charlie Hatton, Connor D. Jones, Eric J. Earley, Lisa McDermott, Dominik Beck, Gerard McGeehan, Duohui Jing, Diego Chacon, Jayant Y. Gadrey, Andrew J. Gifford, Ali Braytee, Malcolm A. Smith, Kathryn Evans, Brian M. McKeever, Hannah Uckelmann, Heather J. Lee, Scott A. Armstrong, Benjamin K. Eschle, John E. Pimanda, Beverly A. Teicher, Jennifer A. Perry
© 2019 Elsevier Inc. Inhibition of the Menin (MEN1) and MLL (MLL1, KMT2A) interaction is a potential therapeutic strategy for MLL-rearranged (MLL-r) leukemia. Structure-based design yielded the potent, highly selective, and orally bioavailable small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ebd22e001d2f241c97a78689254e24
https://hdl.handle.net/10453/137536
https://hdl.handle.net/10453/137536
Autor:
Hiroyuki Shimada, Robyn Lukeis, Junming Fang, Shahab Asgharzadeh, Araz Marachelian, Ryosuke Matsuno, Tohru Sugimoto, Toby Trahair, John M. Maris, Naohiko Ikegaki, Mikako Warren, Andrew J. Gifford
Publikováno v:
Pediatr Dev Pathol
Background Although MYCN (aka N-myc) amplification is reported in ∼20% of neuroblastomas, MYC (aka C-myc) amplification appears to be a rare event in this disease. As of today, only 2 MYC-amplified neuroblastomas have been briefly mentioned in the
Autor:
Chelsea Mayoh, Mitali Fadia, James Blackburn, Roderick Walker, Ashleigh M. Fordham, Draga Barbaric, Santosh Valvi, Toby Trahair, Andrew C. Wood, Glenn M. Marshall, Tim R. Mercer, Karen L. MacKenzie, Robyn Lukeis, Erin E. Heyer, Andrew J. Gifford
Publikováno v:
JCO Precision Oncology
PURPOSE Before anaplastic lymphoma kinase (ALK) inhibitors, treatment options for ALK-positive inflammatory myofibroblastic tumors (AP-IMTs) were unsatisfactory. We retrospectively analyzed the outcome of patients with AP-IMT treated with crizotinib
Autor:
Martin A. Weber, Louise Devisme, Przemyslaw Szafranski, Fernando Scaglia, Megan K. Dishop, Eric Bieth, Claire Beneteau, Bruce Bennetts, Chantal Missirian, David Mowat, Sébastien Küry, Mark H. Lipson, Jennifer N. Dines, Justyna A. Karolak, James R. Lupski, Iben Bache, Amanda S. Freed, Véronique Secq, Bertrand Isidor, Gwenaelle André, Linda Pons, Anne Chun Hui Tsai, Qian Liu, Maria Orsaria, Claudia Gonzaga-Jauregui, Francesco Vetrini, Wendy K. Chung, Nicolas Joram, Jelena Martinovic, Marie Vincent, Cornelius F. Boerkoel, Arie van Haeringen, Tina M. Bartell, Gail H. Deutsch, Olivier Pichon, John A. Phillips, Marie Denis-Musquer, Zeynep Tümer, Tomasz Gambin, Nicolas Chassaing, Thomas Besnard, Edwina J. Popek, Arnaud Molin, Andrew J. Gifford, Zeynep Coban Akdemir, Benjamin Cogné, Kathleen A. Leppig, Galen M. Schauer, Catherine Mercer, Catherine Ward-Melver, Chester W. Brown, Jean Michel Liet, Dominique Carles, Madeleine Joubert, Lara Chalabreysse, Cédric Le Caignec, Damien Sanlaville, Tiphaine Bihouée, Heather C Mefford, Jean P. Pfotenhauer, Pawel Stankiewicz, Massimiliano Don, Anna F. Lee, Jérémie Mortreux, Katrina M. Dipple, Florence Petit, Katie Golden-Grant, Stéphane Bézieau, Shalini N. Jhangiani, Dorothy K. Grange, Laurent Pasquier, Daryl A. Scott
Publikováno v:
American Journal of Human Genetics, 104(2), 213-228. CELL PRESS
American Journal of Human Genetics
American Journal of Human Genetics, 2019, 104 (2), pp.213-228. ⟨10.1016/j.ajhg.2018.12.010⟩
American Journal of Human Genetics, Elsevier (Cell Press), 2019, 104 (2), pp.213-228. ⟨10.1016/j.ajhg.2018.12.010⟩
American Journal of Human Genetics
American Journal of Human Genetics, 2019, 104 (2), pp.213-228. ⟨10.1016/j.ajhg.2018.12.010⟩
American Journal of Human Genetics, Elsevier (Cell Press), 2019, 104 (2), pp.213-228. ⟨10.1016/j.ajhg.2018.12.010⟩
International audience; Primary defects in lung branching morphogenesis, resulting in neonatal lethal pulmonary hypoplasias, are incompletely understood. To elucidate the pathogenetics of human lung development, we studied a unique collection of samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1e4f18fb660d5924e3d01e7a03436d
https://hdl.handle.net/1887/122774
https://hdl.handle.net/1887/122774
Autor:
Bryce Keenan, Chelsea Mayoh, Giovanni Perini, Michelle Haber, Janith A. Seneviratne, Mika Herath, Stefan Hüttelmaier, Tao Liu, Jessica L. Bell, Jamie I. Fletcher, Michael W. Parker, Olivia C. Ciampa, Glenn M. Marshall, Daniel R. Carter, Michael A. Gorman, André Oberthuer, Matthias Fischer, Andrew J. Gifford, Jayne Murray, Joshua A. McCarroll, Shizhen Zhu, Larissa Doughty, Bing Liu, Hassina Massudi, Jessica K. Holien, Jessica Koach, Xiaoling Zhang, Taylor Lim, W. Clay Gustafson, Giorgio Milazzo, Belamy B. Cheung, Brendan W. Stevenson, Murray D. Norris
MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN protein stability is a key component of MYCN oncogenesis and is maintained by multiple feedforward expression loops involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d96dc84bb92b70424c201d44c3d03ca
http://hdl.handle.net/11585/704926
http://hdl.handle.net/11585/704926
Autor:
Murray D. Norris, Catherine Kennedy, Michelle Haber, Amanda J. Russell, Anna deFazio, MoonSun Jung, Michelle J. Henderson, Kylie-Ann Mallitt, David D.L. Bowtell, Siva Sivarajasingam, Andrew J. Gifford
Publikováno v:
JNCI Cancer Spectrum
Background The Myc oncogene family has been implicated in many human malignancies and is often associated with particularly aggressive disease, suggesting Myc as an attractive prognostic marker and therapeutic target. However, for epithelial ovarian
Autor:
Jie Liu, Richard J. Cohn, Julia X. Yin, Andrew J. Gifford, Michael Rodriguez, Martin A. Weber, Warren Kaplan, Laura Franshaw, Federica Saletta, Swapna Joshi, Tim Failes, Kerrie L. McDonald, Glenn M. Marshall, Carol Wadham, Mark J. Cowley, Emily Mould, Paul G Ekert, Greg M. Arndt, Vanessa Tyrrell, Velimir Gayevskiy, Mark Pinese, Amit Kumar, David S. Ziegler, Toby Trahair, Maria Tsoli, Michelle Haber
Publikováno v:
Cancer Biology & Therapy
Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges in their treatment is inter- and intra-tumoral heterogeneity. Precision medicine approaches have the potential
Autor:
Jennifer Trieu, Andrew J. Gifford, Joshua A. McCarroll, Sharon M. Sagnella, Jennifer A. MacDiarmid, Christopher M. Fife, Renee Whan, David S. Ziegler, Maria Kavallaris, Himanshu Brahmbhatt, Alexander Macmillan
Publikováno v:
Molecular cancer therapeutics. 17(5)
Advanced stage neuroblastoma is an aggressive disease with limited treatment options for patients with drug-resistant tumors. Targeted delivery of chemotherapy for pediatric cancers offers promise to improve treatment efficacy and reduce toxicity ass