Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Amit Deorukhkar"'
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Autor:
Nicholas D. Nguyen, Jason B. Fleming, Meifang Yu, Eugene J. Koay, Ya'an Kang, F. Anthony San Lucas, Sonal Gupta, Haoqiang Ying, Daniel Lin, Albert C. Koong, Cullen M. Taniguchi, Anirban Maitra, Jessica M. Molkentine, Tara N. Fujimoto, Joseph M. Herman, Conrad J. Fernandes, Amit Deorukhkar, Yanqing Huang
Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might also disrupt essential mitochondrial functions in normal tissues. PDAC cells exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3babfceaa2914d8d295a54c5f9366df
https://europepmc.org/articles/PMC6777817/
https://europepmc.org/articles/PMC6777817/
Autor:
Bhanu Prasad Venkatesulu, Ramesh C. Tailor, John S. Bomalaski, Xiaolin Li, Pankaj Singh, Amit Deorukhkar, Sunil Krishnan
Publikováno v:
Mol Cancer Ther
Distinct metabolic vulnerabilities of cancer cells compared with normal cells can potentially be exploited for therapeutic targeting. Deficiency of argininosuccinate synthetase-1 (ASS1) in pancreatic cancers creates auxotrophy for the semiessential a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192ca1c746f222d34e88fe0fbaf50cfe
https://europepmc.org/articles/PMC6891156/
https://europepmc.org/articles/PMC6891156/
Autor:
Carolina J. Garcia Garcia, James M. Tour, Wai Kin Chan, Aaron J. Grossberg, Tara N. Fujimoto, Philip L. Lorenzi, Robert Dantzer, Daniel Lin, Thomas D. Horvath, Jessica M. Molkentine, Cullen M. Taniguchi, Kathy A. Mason, Marimar de la Cruz Bonilla, Errol L. G. Samuel, Helen Piwnica-Worms, Amit Deorukhkar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable disease is that the radiatio