Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Abigail Ngoepe"'
Autor:
Alessandra Nardin, Rajhmun Madansein, Amanda Ardain, Khadija Khan, Kaylesh J. Dullabh, Alveera Singh, Taryn Naidoo, Alessandro Sette, Farina Karim, Samuel M. Behar, Alasdair Leslie, Paul T. Elkington, Liku B. Tezera, Duran Ramsuran, Michael G. Fehlings, Abigail Ngoepe, Paul Ogongo, Cecilia S. Lindestam Arlehamn, Henrik N. Kløverpris, Shepherd Nhamoyebonde, Adrie J. C. Steyn, Boon Heng Lee
Publikováno v:
The Journal of Clinical Investigation
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells (Trms) are
Autor:
Warren Kuhn, Duran Ramsuran, Maximilian Muenchhoff, Philip J. R. Goulder, Jane Millar, Alasdair Leslie, J Roider, Alex K. Shalek, Thumbi Ndung'u, Henrik N. Kløverpris, Osaretin E. Asowata, Kami C. Krista, Samuel W. Kazer, Amanda Ardain, Farina Karim, Abigail Ngoepe, Rabiah Fardoos, Alveera Singh
Publikováno v:
Cell Reports
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Summary Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating ILCs, but the impact on children infected from birth remains unknown. We study vertica
Autor:
Julia Roider, Abigail Ngoepe, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Thumbi Ndung'u, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in immunology
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Roider, J, Ngoepe, A, Muenchhoff, M, Adland, E, Groll, A, Ndung'u, T, Kløverpris, H, Goulder, P & Leslie, A 2019, ' Increased regulatory T-cell activity and enhanced T-cell homeostatic signaling in slow progressing HIV-infected children ', Frontiers in Immunology, vol. 10, no. FEB, 213 . https://doi.org/10.3389/fimmu.2019.00213
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Roider, J, Ngoepe, A, Muenchhoff, M, Adland, E, Groll, A, Ndung'u, T, Kløverpris, H, Goulder, P & Leslie, A 2019, ' Increased regulatory T-cell activity and enhanced T-cell homeostatic signaling in slow progressing HIV-infected children ', Frontiers in Immunology, vol. 10, no. FEB, 213 . https://doi.org/10.3389/fimmu.2019.00213
Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulator
Autor:
Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Samuel W. Kazer, Pieter Jooste, Farina Karim, Warren Kuhn, Alex K. Shalek, Thumbi Ndung'u, Lynn Morris, Penny L. Moore, Shiv Pillai, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in immunology
Frontiers
Roider, J, Maehara, T, Ngoepe, A, Ramsuran, D, Muenchhoff, M, Adland, E, Aicher, T, Kazer, S W, Jooste, P, Karim, F, Kuhn, W, Shalek, A K, Ndung'u, T, Morris, L, Moore, P L, Pillai, S, Kløverpris, H, Goulder, P & Leslie, A 2018, ' High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults ', Frontiers in Immunology, vol. 9, 1975 . https://doi.org/10.3389/fimmu.2018.01975
Frontiers in immunology
Frontiers
Roider, J, Maehara, T, Ngoepe, A, Ramsuran, D, Muenchhoff, M, Adland, E, Aicher, T, Kazer, S W, Jooste, P, Karim, F, Kuhn, W, Shalek, A K, Ndung'u, T, Morris, L, Moore, P L, Pillai, S, Kløverpris, H, Goulder, P & Leslie, A 2018, ' High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults ', Frontiers in Immunology, vol. 9, 1975 . https://doi.org/10.3389/fimmu.2018.01975
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infecti