Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jan Tavernier"'
Autor:
Bart Vandekerckhove, Anje Cauwels, Gilles Uzé, An Goethals, Stijn De Munter, Nele Vanderroost, Alexander Van Parys, Frank Peelman, Jan Tavernier, Jennyfer Bultinck, Peter Brouckaert, Annick Verhee, Jeroen Hostens, Leander Huyghe, Sandra Van Lint, Niko Kley, Lennart Zabeau
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, ⟨10.15252/emmm.201911223⟩
EMBO MOLECULAR MEDICINE
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, ⟨10.15252/emmm.201911223⟩
EMBO MOLECULAR MEDICINE
Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index. A TNF‐based
Autor:
T.M. Wijesuriya, Jan Tavernier, Rachel Wevrick, Leentje De Ceuninck, Karin Vanessa Carias, Delphine Masschaele, Matthea R. Sanderson
Publikováno v:
Human Molecular Genetics. 26:4215-4230
In Prader-Willi syndrome (PWS), obesity is caused by the disruption of appetite-controlling pathways in the brain. Two PWS candidate genes encode MAGEL2 and necdin, related melanoma antigen proteins that assemble into ubiquitination complexes. Mice l
Autor:
Claude Libert, Marlies Ballegeer, Jan Tavernier, Ioanna Petta, Sam Lievens, Lien Dejager, Karolien De Bosscher
Publikováno v:
Microbiology and Molecular Biology Reviews. 80:495-522
SUMMARYGlucocorticoids (GCs) have been widely used for decades as a first-line treatment for inflammatory and autoimmune diseases. However, their use is often hampered by the onset of adverse effects or resistance. GCs mediate their effects via bindi
Autor:
Jan Tavernier, Delphine De Sutter, Delphine Masschaele, Joris Wauman, Giel Vandemoortele, Leentje De Ceuninck, Sven Eyckerman
Publikováno v:
Journal of proteome research. 17(4)
Ring finger protein 41 (RNF41) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of many proteins including ErbB3 receptors, BIRC6, and parkin. Next to this, RNF41 regulates the intracellular trafficking of certain JAK2-associa
Autor:
Jan Tavernier, Dorien Clarisse, Karlien Van Wesemael, Ilse M. Beck, Fritz Offner, Karolien De Bosscher
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use is hampered by deleterious GC-related side effects and the emergence of GC r
Autor:
Riet De Rycke, Kris Gevaert, Viacheslav Mylka, Lode De Cauwer, Claude Libert, Julie Deckers, Wim Vanden Berghe, Jan Tavernier, Francis Impens, Jonathan Thommis, Dariusz Ratman, Karolien De Bosscher
Publikováno v:
Autophagy
AUTOPHAGY
AUTOPHAGY
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid recepto
Autor:
Lode De Cauwer, Claude Libert, Sam Lievens, Jonathan Thommis, Nadia Bougarne, Jan Tavernier, Marlies Ballegeer, Sofie Desmet, Ioanna Petta, Lien Dejager, Sofie Vandevyver, Karolien De Bosscher, Jolien Vandewalle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s l
Autor:
K. De Bosscher, Jonathan Thommis, Marnik Vuylsteke, Nadia Bougarne, Sofie Desmet, René Houtman, Dariusz Ratman, Jan Tavernier, L. De Cauwer, L. Van de Moortel
Publikováno v:
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in variou
Autor:
Michael B. Drennan, S. Van Calenbergh, Lennart Zabeau, Mérédis Favreau, Sylvia Faict, E. De Bruyne, Srinath Govindarajan, Karin Vanderkerken, Eline Menu, Dirk Elewaut, Ken Maes, Koen Venken, Jan Tavernier, Djoere Gaublomme, Xavier Leleu
Publikováno v:
Leukemia. 31(12)
A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as master regulator of anti-myeloma tumor im
Publikováno v:
Frontiers in Endocrinology
FRONTIERS IN ENDOCRINOLOGY
FRONTIERS IN ENDOCRINOLOGY
Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight by balancing food intake and energy expenditure. However, this adipocyte-derived hormone also directs peripheral processes, including immunity, repro