Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yu Yan"'
Autor:
Chun Xie, Min Huang, Qibiao Wu, Elaine Lai-Han Leung, Xiao-Jun Yao, Yi-Zhong Zhang, Ju-Min Huang, Ze-Bo Jiang, Xing-Xing Fan, Liang Liu, Yupo Ma, Pei-Yu Yan, Ya-Jia Xie, Cong Xu, Wen-Jun Wang, Xuan-Run Wang, Pei Liu
Publikováno v:
Cancer Letters. 515:36-48
Upregulated expression of immune checkpoint molecules correlates with exhausted phenotype and impaired function of cytotoxic T cells to evade host immunity. By disrupting the interaction of PD-L1 and PD1, immune checkpoint inhibitors can restore immu
Autor:
Li-Chao Zhang, Yao Wu, Xiao-Yu Yan, Liankun Sun, Rui Guo, Bingbing Yu, Yang Li, Jing Su, Jiuling Li, Ya-Nan Xue, Yanan Liu
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 8, Iss 5, Pp 2462-2473 (2019)
Cancer Medicine, Vol 8, Iss 5, Pp 2462-2473 (2019)
Metabolic reprogramming is a central hallmark of cancer. Therefore, targeting metabolism may provide an effective strategy for identifying promising drug targets for cancer treatment. In prostate cancer, cells undergo metabolic transformation from zi
Autor:
Changtao Jiang, Pengcheng Wang, Huiying Liu, Song-Yang Zhang, Yang Zhao, Lulu Sun, Xun Wu, Xian Wang, Guangyi Zeng, Lei Wang, Bo Liu, Guoheng Xu, Yu Yan
Publikováno v:
Redox Biology, Vol 37, Iss, Pp 101742-(2020)
Redox Biology
Redox Biology
Hyperhomocysteinemia (HHcy) is related to liver diseases, such as nonalcoholic fatty liver (NAFL). Although the precise pathogenesis of NAFL is still largely unknown, the links between organs seem to play a vital role. The current study aimed to expl
Autor:
Lu-Ping Tang, Hai-Biao Gong, Yu-Hui Lu, Shu-Hua Ouyang, Yan-Ping Wu, Wen Li, Yang Yu, Tongzheng Liu, Rong-Rong He, Long-Fang Tu, Hiroshi Kurihara, Ying-Nan Jiang, Chang-Yu Yan, Zhenyou Jiang, Li-Fang Liu, Shan Jiang, Xin-Sheng Yao, Yi-Fang Li, Zhuo Luo
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-12 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infected with th
Autor:
Pengcheng Wang, Bo Chen, Guangyi Zeng, Xiaomin Hu, Lulu Sun, Daisuke Aibara, Changtao Jiang, Feng Xu, Chuyu Yun, Frank J. Gonzalez, Shuyang Zhang, Yicheng Zhu, Xianyi Liang, Shaofei Zhang, Yu Yan, Qing Wu, Xuemei Wang, Michael Bustin, Jialin Xia
Publikováno v:
J Clin Invest
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Systemic lupus erythaematosus (SLE) is a chronic multi-system autoimmune disease with a high prevalence of kidney and cardiovascular complications. Considering that Rho-associated coiled-coil-containing protein kinases (ROCKs) play important roles in
Autor:
Xiao-Jun Yao, Lin Wang, Wen-Jun Wang, Imran Khan, Jian-Lin Wu, Ya-Jia Xie, Yabing Cao, W.L. Wendy Hsiao, A-Xi Shi, Ze-Bo Jiang, Yuwei Wang, Qibiao Wu, Lian-Xiang Luo, Zhi-Hong Jiang, Jing-Guang Lu, Yu Fu, Hong Wei, Jun Cai, Elaine Lai-Han Leung, Di Liu, Ying Xie, Ju-Min Huang, Zhongqiu Liu, Haizhou Liu, Huan-Ling Lai, Jian Li, Ming-Rong Yang, Pei-Yu Yan, Liang Liu, Yi-Zhong Zhang, Xing-Xing Fan, Jing Yuan, Run-Ze Li, Junyi Liao
Publikováno v:
Gut. 71(4)
ObjectiveProgrammed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be improved. Gut microbiota plays a crucial role in immunotherapy sensitisation and Panax g
Autor:
Jun-Ling Yang, Yibing Guo, Jia-Zhou Liu, Xi Chen, Ying Feng, Qin-Sheng Mao, Yun Jiang, Yi-Lin Hu, Wan-Jiang Xue, Yu-yan Chen, Yifei Liu
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Background 3-Hydroxy butyrate dehydrogenase 2 (BDH2) is a short-chain dehydrogenase/reductase family member that plays a key role in the development and pathogenesis of human cancers. However, the role of BDH2 in gastric cancer (GC) remains largely u
Publikováno v:
Inflammation. 41:2012-2017
Terpinen-4-ol, the major constituent of tea tree oil, has been reported to have anti-inflammatory effect. However, whether terpinen-4-ol could attenuate LPS-induced inflammation in lung tissues remains unclear. In the present study, we aimed to inves
Autor:
Thomas Van Blarcom, Surabhi Srinivasan, Cendy Valle Oseguera, Sheng Ding, Arvind Rajpal, Purnima Sundar, Yu Yan, Dan McDonough, Zygy Roe-Zurz, Meri Galindo Casas, Wai Ling Cheung, Zea Melton, Shobha Potluri, Javier Chaparro-Riggers, Kevin Lindquist, Wagstrom Christopher R, Wenwu Zhai, Jaume Pons, Andrea Rossi, Steven J. Pitts, Jeffrey Jones, Marina Sirota
Publikováno v:
mAbs, vol 10, iss 2
mAbs
mAbs
The commercial success of bispecific antibodies generally has been hindered by the complexities associated with generating appropriate molecules for both research scale and large scale manufacturing purposes. Bispecific IgG (BsIgG) based on two antib