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Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 26, Iss, Pp 15-19 (2021)
Objectives Based on recent pharmacokinetic/pharmacodynamic (PK/PD) evidence, continuous-infusion (CI) β-lactam administration is increasingly recommended for serious infections. Since 2016, the combination ceftazidime/avibactam (CAZ/AVI) is administ
Autor:
Lily Mohammadipoor-ghasemabad, Abdolreza Babaee, Parisa Vosough, Mohsen Basiri, Samereh Dehghani-Soltani, Meysam Ahmadi-Zeidabadi, Seyed Hassan Eftekhar-Vaghefi
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 36:579-587
Background: Glioblastoma is a malignant and very aggressive brain tumor with a poor prognosis. Despite having chemotherapy concomitant with surgery and/or radiation therapy, the median survival of ...
Autor:
Danh Tuyen Le, Shuhei Ueda, Kouta Hamamoto, Kim Ngan Thi Bui, Itaru Hirai, Mai Huong Thi Bui, Nobuyoshi Yagi, Saki Tawata
Publikováno v:
Journal of Infection and Chemotherapy. 27:1288-1294
Introduction Because blaCTX-M is responsible for resistance of bacteria to the third generation cephalosporins, location of blaCTX-M could be a good indicator for classifying bacterial isolates harboring blaCTX-M in molecular epidemiology. However, d
Autor:
Jinzhao Zhu, Zhenhua Li, Kun Wu, Xue Luo, Xiangdong Zhang, Jiangang Zhang, Ke Sun, Weizheng Xie, Qingcheng Yang
Publikováno v:
Brain Research Bulletin. 174:11-21
Dexmedetomidine (Dex) has been suggested to exert a protective function in ischemic brain injury. In this study, we aimed to elucidate the intrinsic mechanisms of Dex in regulating microglia pyroptosis in ischemic brain injury via the purinergic 2X7
Autor:
John Wrangle, Ticiana Leal, Gilles Robinet, Neal Ready, David Maag, Jyoti Malhotra, Melissa Lynne Johnson, Satwant Lally, Petros Nikolinakos, Jyoti D. Patel, Daniel Morgensztern, Benjamin Besse, Vincent Blot, Giuseppe Curigliano, Ricardo Valenzuela, Laurent Greillier, Jonathan M. Lehman
Publikováno v:
Journal of Thoracic Oncology
Journal of Thoracic Oncology, 2021, 16 (9), pp.1559-1569. ⟨10.1016/j.jtho.2021.02.022⟩
Journal of Thoracic Oncology, 2021, 16 (9), pp.1559-1569. ⟨10.1016/j.jtho.2021.02.022⟩
Introduction This open-label, phase 1–2 study evaluated the safety and efficacy of rovalpituzumab tesirine (Rova-T), an antibody-drug conjugate targeting DLL3, plus immune checkpoint inhibitors nivolumab plus or minus ipilimumab in previously treat
Autor:
C. Kors van der Ent, Renske van der Meer, Sylvia F. Boj, Robert G.J. Vries, Harry G.M. Heijerman, Peter van Mourik, Paul K. Audhya, Jamie R Doyle, Jeffrey M. Beekman, Zheng Jason Yuan, N. Kinnman, Gitte Berkers
Publikováno v:
Journal of Cystic Fibrosis. 20:761-767
Background Previous in vitro organoid data showed A455E–CFTR, a rare CFTR mutation with 4.1% prevalence in the Netherlands, responds to lumacaftor/ivacaftor (LUM/IVA). We explored LUM/IVA's clinical efficacy in people with CF and ≥1 A455E–CFTR
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 33-39 (2021)
In contrast with the delayed onset of therapeutic responses and relatively low efficacy of currently available monoamine-based antidepressants, a single subanesthetic dose of ketamine, an N-methyl-D-aspartate receptor antagonist, produces rapid and s
Autor:
L. Yang, Corinne Schneider, Vinh Dang, L. A. Van Der Kraak, J. A. Varghese, Timothy W. Hand, Eric S. Weiss, Scott W. Canna, Ansen H.P. Burr
Publikováno v:
Mucosal immunology
Major Histocompatibility Complex Class II (MHCII) is dynamically expressed on intestinal epithelial cells (IECs) throughout the intestine, but its regulation remains poorly understood. We observed that spontaneous upregulation of IEC MHCII in locally
Autor:
Jun Gu, Xiaoyu Chen, Wenhua Zhou, Xiaohu Xie, Longhui Li, Huifen Liu, Weisheng Chen, Wenwen Shen, Dingding Zhuang, Yue Liu, Yun Zhou, Wenjin Xu, Qingxiao Hong
Publikováno v:
Personalized Medicine. 18:423-430
Aim: This study determined if gene variants in the GABA receptor delta subunit ( GABRD) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. Materials & methods: A total of 286 MMT patients we
Autor:
Yuki Kurauchi, Takeshi Masuda, Keita Kinoshita, Masanori Hijioka, Akinori Hisatsune, Kosei Matsumoto, Takahiro Seki, Hiroshi Katsuki, Sumio Ohtsuki
Publikováno v:
Neuroscience Research. 170:284-294
Here we examined the effect of nicotine on angiogenesis in the brain after intracerebral hemorrhage (ICH), as angiogenesis is considered to provide beneficial effects on brain tissues during recovery from injury after stroke. Nicotine was administere