Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Crispin A"'
Autor:
John G. Edwards, Matthew Neilson, Davand Sharma, Fiona T. Thomson, Carol McCormick, Caroline Kelly, Euan J. Cameron, Seamus Grundy, Stephen R. L. Clark, Samantha Hinsley, David Breen, Angela Wright, Dipak Mukherjee, Crispin J. Miller, Rachel Ostroff, Alan Hart-Thomas, J Holme, Mohammed Munavvar, Ioannis Psallidas, Giles Cox, Holly Hall, Rakesh Panchal, Nick A Maskell, Rehan Naseer, Matthew Evison, Leigh Alexander, Laura Alexander, Mahendran Chetty, Alina Ionescu, S. Tsim, Elankumaran Paramasivam, Kevin G. Blyth, Ann Shaw, Douglas Grieve, Anthony J. Chalmers, C Daneshvar
Publikováno v:
Journal of Thoracic Oncology
Introduction:\ud Malignant pleural mesothelioma (MPM) is difficult to diagnose. An accurate blood biomarker could prompt specialist referral or be deployed in future screening. In earlier retrospective studies, SOMAscan proteomics (Somalogic, Boulder
Autor:
Kristopher K. Frese, Donna M. Graham, Nicholas Hickson, Alexandra Clipson, Crispin J. Miller, Sumitra Mohan, Saba Ferdous, Matthew G Krebs, Alexander J Vickers, Bedirhan Kilerci, Helen Eaton, Caroline Dive, Siobhan Southam, Roopa Kurup, Hannah Frost, Ciara O’Brien, Fiona C Thistlethwaite, Richard Marais, Allan M. Jordan, Mahmood Ayub, Robert Metcalf, Jaseela Chiramel, Louise Carter, Daniel J. White, Emma Dean, Matthew Howell, Sreeja Aruketty, Avinash Gupta, Joanne Dransfield, Ged Brady, Kamrun Nessa, Donal Landers, Claire L. S. Kelly, Shaun Villa, Julie Stevenson, Dominic G. Rothwell, Nigel K Smith, Andrew Hughes, Nadina Tinsley, Natalie Cook, Sakshi Gulati, Andrew L. Wallace
Publikováno v:
Rothwell, D, Ayub, M, Cook, N, Thistlethwaite, F, Carter, L, Dean, E, Smith, N, Villa, S, Dransfield, J, Clipson, A, White, D, Nessa, K, Ferdous, S, Howell, M, Gupta, A, Kilerci, B, Mohan, S, Frese, K, Gulati, S, Miller, C, Jordan, A, Eaton, H, Hickson, N, O'Brien, C, Graham, D, Kelly, C, Aruketty, S, Metcalf, R, Chiramel, J, Tinsley, N, Vickers, AJ, Kurup, R, Frost, H, Stevenson, J, Southam, S, Landers, D, Wallace, A, Marais, R, Hughes, AM, Brady, G, Dive, C & Krebs, M 2019, ' Utility of ctDNA to support patient selection for early phase clinical trials: The TARGET Study ', Nature Medicine, vol. 25, no. 5, pp. 738-743 . https://doi.org/10.1038/s41591-019-0380-z, https://doi.org/10.1038/s41591-019-0380-z
Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a phase I trials clinic. TARGET is a molecular profiling program with the primary aim to m
Publikováno v:
Injury. 49:1739-1745
Introduction Leptinʼs role in bone formation has been reported, however, its mechanism of affecting bone metabolism is remaining unclear. In this study, we aimed to test whether leptin has a positive effect on fracture healing through the possible m
Autor:
Cary Oberije, Monique C. de Jong, Dario Neri, Vincenzo Valentini, Giuliano Elia, Relinde I Y Lieverse, Yolande Lievens, Esther G.C. Troost, Evert J. Van Limbergen, Franziska Eckert, Charlotte Billiet, X. Geets, Ala Yaromina, Amir Abdollahi, P. Boisselier, Lizza E.L. Hendriks, Philippe Lambin, Crispin T. Hiley, Johan Bussink, Ludwig Dubois, David Pasquier, Christophe Dooms, Sine Reker Hadrup, Dirk De Ruysscher, Anne-Marie C. Dingemans
Publikováno v:
Lieverse, R I Y, Van Limbergen, E J, Oberije, C J G, Troost, E G C, Hadrup, S R, Dingemans, A-M C, Hendriks, L E L, Eckert, F, Hiley, C, Dooms, C, Lievens, Y, de Jong, M C, Bussink, J, Geets, X, Valentini, V, Elia, G, Neri, D, Billiet, C, Abdollahi, A, Pasquier, D, Boisselier, P, Yaromina, A, De Ruysscher, D, Dubois, L J & Lambin, P 2020, ' Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial ', BMC Cancer, vol. 20, no. 1, 557 . https://doi.org/10.1186/s12885-020-07055-1
BMC cancer
BMC Cancer, 20(1). BioMed Central Ltd.
BMC Cancer, 20, 1
BMC Cancer, 20(1):557. BioMed Central Ltd
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer, 20 (1)
BMC cancer, Vol. 20, no.1, p. 557 [1-10] (2020)
BMC Cancer, 20
BMC Cancer
BMC CANCER
BMC cancer
BMC Cancer, 20(1). BioMed Central Ltd.
BMC Cancer, 20, 1
BMC Cancer, 20(1):557. BioMed Central Ltd
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer, 20 (1)
BMC cancer, Vol. 20, no.1, p. 557 [1-10] (2020)
BMC Cancer, 20
BMC Cancer
BMC CANCER
Background About 50% of non-small cell lung cancer (NSCLC) patients have metastatic disease at initial diagnosis, which limits their treatment options and, consequently, the 5-year survival rate (15%). Immune checkpoint inhibitors (ICI), either alone
Autor:
Sylvain Biéler, Anne J. N. Kazibwe, Enock Matovu, Crispin Lumbala, Pascal Lutumba, Hakim Sendagire, Simon Kayembe, Joseph Mathu Ndung'u, Hypolite Muhindo Mavoko, Jean-Pierre Van Geertruyden, Joris Losimba Likwela
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008168 (2020)
PLoS neglected tropical diseases
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases
PLoS Neglected Tropical Diseases
Background Malaria is endemic in all regions where gambiense or rhodesiense human African trypanosomiasis (HAT) is reported, and both diseases have similarities in their symptomatology. A combined test could be useful for both diseases and would faci
Autor:
Christoph B. Westphalen, Leonie Gebauer, Karoline Schirle, Volker Heinemann, Julia Mayerle, Stefan Boeck, Matthias Ilmer, Jan G. D’Haese, Sebastian Kobold, Michael von Bergwelt-Baildon, Thomas Kirchner, Michael Haas, Stephan Kruger, Jens Ricke, Jens Werner, Jörg Schirra, Steffen Ormanns, Alexander Crispin, Wolfgang G. Kunz
Publikováno v:
Journal of cancer research and clinical oncology. 146(2)
A prolonged time to treatment initiation (TTI) correlates with an adverse prognosis in different cancer types including resectable pancreatic cancer (PC). Only limited evidence on the correlation between TTI and prognosis in advanced PC exists. Conse
Autor:
Crispin Kahesa, Cameron Klein, Charles E. Wood, John T. West, Julius Mwaiselage, Peter C. Angeletti
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. Besides HPV infection, definitive factors of cervical cancer are still unclear. Particular states of the cervicovaginal microbiota and
Autor:
Marion Hoerl, I. Kumprej, Alexander Crispin, Igor B. Mekjavic, Manfred Thiel, Tadej Debevec, R. Zeller, Matthias Feuerecker, Bernd Johannes, Alexander Choukèr, Ola Eiken, Gustav Schelling, Sandra Matzel, Claudia Strewe
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesti
Autor:
Bruno Scherrer, Victor Kande Betu Ku Mesu, Crispin Lumbala, Olaf Valverde Mordt, Nathalie Strub-Wourgaft, Wilfried Mutombo Kalonji, Séverine Blesson, Willy Kuziena, Jean Pierre Fina Lubaki, Steven Lumeya Vuvu, Pathou Nganzobo Ngima, Augustin Kasongo Bonama, François Simon, Lewis Kaninda Badibabi, Jean Louis Lumaliza Solomo, Medard Ilunga, Sonja C. Bernhard, Francis Regongbenga Dama, Josué Amici Heradi, Guylain Mandula, Papy Kavunga Lukula, Clélia Bardonneau, Hélène Mahenzi Mbembo, Digas Ngolo Tete, Sophie Delhomme, Antoine Tarral
Publikováno v:
The Lancet. 391:144-154
Summary Background Few therapeutic options are available to treat the late-stage of human African trypanosomiasis, a neglected tropical disease, caused by Trypanosoma brucei gambiense (g-HAT). The firstline treatment is a combination therapy of oral
Autor:
Ursula Vehling-Kaiser, Marlies Michl, Jobst C. von Einem, Andreas Jung, Thomas Kirchner, Julian Walter Holch, Andreas Schalhorn, Jens Neumann, Arndt Stahler, Sebastian Stintzing, D. Quietzsch, Stephan Kruger, Dominik Paul Modest, Alexander Crispin, Martina Stauch, Clemens Giessen-Jung, Volker Heinemann, Ludwig Fischer von Weikersthal, Michael J. Haas
Publikováno v:
Anti-Cancer Drugs. 28:717-722
Our aim was to explore the impact of the HER2/neu, HER3 receptor as well as their ligands' neuregulin (NRG1) expression on the outcome of patients with metastatic colorectal cancer (mCRC). NRG1, HER2/neu and HER3 expression was evaluated in 208 patie