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Publikováno v:
Human & Experimental Toxicology. 40:2145-2155
Objective: To explore the mechanism of dexmedetomidine (DEX)-mediated miR-134 inhibition in hypoxia-induced damage in PC12 cells. Methods: Hydrogen peroxide (H2O2)-stimulated PC12 cells were divided into control, H2O2, DEX + H2O2, miR-NC/inhibitor +
Autor:
Tabish Rehman, Mohammad Rashid Khan, Mohd Shahnawaz Khan, Ghaida I Alruwaished, Mohamed F. Alajmi, Mohamed A. Ismael, Majed S. Alokail
Publikováno v:
Cell Biochemistry and Biophysics. 79:833-844
Alpha-amylase (α-amylase) not long ago has acquire recognition as a possible drug target for the management of diabetes. Here, we have investigated the binding and enzyme activity of α-amylase by hesperidin; a naturally occurring flavanone having w
Autor:
Mullam Kunnathu A Shamsitha, Punnakkal Seena, Vaishak Penarveettil Nair, Achuthan C. Raghavamenon, Veena Gopinath, Rao M. Uppu
Publikováno v:
Cell Biochemistry and Biophysics. 79:629-639
In the present study, HFD/STZ-mediated type 2 diabetic rodent model was used to comparatively evaluate coconut oil (CO) and thermally oxidized CO (TCO) as fat sources for the development of NAFLD. Female Wistar rats (six in each group; average bwt 20
Publikováno v:
Human & Experimental Toxicology. 40:2123-2134
Doxorubicin (DOX) is an anticancer drug which is used for treatment of several types of cancers. But the clinical use of doxorubicin is limited because of its cardiotoxicity and cardiomyopathy. Mitochondrial-dependent oxidative stress and cardiac inf
Autor:
Marcus V. G. Lacerda, Flavio Pereira, Antônio Alcirley da Silva Balieiro, Monick Lindenmeyer Guimarães, Paulo Nogueira, Diego Rafael Lima Batista, Yury Oliveira Chaves, Rebeca de Souza Pinheiro
Publikováno v:
BioMed Research International, Vol 2021 (2021)
BioMed Research International
BioMed Research International
Virologic failure may occur because of poor treatment adherence and/or viral drug resistance mutations (DRM). In Brazil, the northern region exhibits the worst epidemiological scenarios for the human immunodeficiency virus (HIV). Thus, this study is
Autor:
Takayuki Yoshino, Hiroya Taniguchi, Ichiro Takemasa, Saori Mishima, Hiroki Yukami, Daisuke Kotani, Kentaro Sawada, Takeharu Yamanaka, Yoshiaki Nakamura, Hiromichi Ebi, Takeshi Kato, Masaki Mori, Hiromichi Shirasu, Alexey Aleshin, Paul Billings, Eiji Oki, Matthew Rabinowitz
Publikováno v:
Cancer Science
Adjuvant chemotherapy has reduced the risk of tumor recurrence and improved survival in patients with resected colorectal cancer. Potential utility of circulating tumor DNA (ctDNA) prior to and post surgery has been reported across various solid tumo
Autor:
Arghavan Memarzia, Hamideh Kazemi Rad, Fatemeh Amin, Mohammad Hossein Boskabady, Farzaneh Shakeri
Publikováno v:
BioFactors. 47:778-787
Control rats were exposed to saline aerosol, two groups were exposed to paraquat (PQ), 27 (PQ-L) and 54 (PQ-H) mg/m3 aerosols and six groups were treated with carvacrol, 20 (C-L) and 80 (C-H) mg/kg/day, pioglitazone, 5 (Pio-L) and 10 (Pio-H) mg/kg/da
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Medical series. 18:169-176
The objective of the study was to develop the problem of complex treatment of surgical infections of the skin and soft tissues (SISST).The studies were carried out in 201 patients with SISST who were treated at the Department of Purulent Surgery of t
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Medical series. 18:220-227
The anti-inflammatory properties of the combination of meloxicam and atypical NSAID N-acetyl-L-proline (Groceprol®) after intragastric administration in a model of carrageenan paw edema in mice were studied. The average effective dose of N-acetyl-L-
Publikováno v:
Molecular Biology Reports. 48:5045-5055
The results we obtained from this study gave information about the determination of alpha 7 nicotinic acetylcholine receptor (α7-nACh) expression in human erythroleukemia cells, as well as whether it has a role in calcium release and cell proliferat