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Autor:
Lin Lilong, Jiahao Lu, Liu Dongyu, Li Zhihuan, Yi Zeng, Lin-Hui Qiu, Shilun Yang, Yin-Zhong Ma, Junlei Chang, Lisha Wang
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue origins on metabolic disorders can be varied in many ways but remains poorly defined. Here we report a comprehensive comparison of human MSCs derived from umbili
Autor:
Amir Ali Sohrabpour, Mahshid Saleh, Iman Seyhoun, Javad Verdi, Vahid Siavashi, Neda Alijani, Mahdi Shadnoush, Leila Aghaghazvini, Bahram Chahardouli, Rasoul Aliannejad, Amir Abbas Vaezi, Seyedeh Zahra Fotook Kiaei, Batoul Khoundabi, Shahriyar Abdoli
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Mesenchymal stem cells (MSCs) have received particular attention because of their ability to modulate the immune system and inhibit inflammation caused by cytokine storms due to SARS-CoV-2. New alternative therapies may reduce mortality ra
Autor:
Yanhong Li, Guiying Shi, Wei Liang, Haiquan Shang, Yunlin Han, Wenjie Zhao, Huiwu Li, Lin Bai, Chuan Qin
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS is associated with serious cardiovascular disease and remains the leading cause of mortality worldwide. Mesenchymal stem cells (MSCs) hav
Autor:
Ru-Chun Dai, Meilu Liu, Fen Xie, Yuling Liu, Jingqiong Xun, Qiongfei Zhou, Chan Li, Yueming Mei, Bo Wu
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Osteoporosis is a major public health concern for the elderly population and is characterized by fatigue load resulting in bone microdamage. The ability of bone mesenchymal stem cells (BMSCs) to repair bone microdamage diminishes with age,
Autor:
Lale Bakir, Ayman Al-Hendy, Prosper Igboeli, Amro Elsharoud, Hang-Soo Park, Jan M. McAllister, Sahar Esfandyari, Abdeljabar El Andaloussi, Rishi Man Chugh, Nahed Ismail, Mara Ulin, Mohamed Ali, Dalia Ashour, Alshimaa Aboalsoud
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features of PCOS. Human bone marrow me
Publikováno v:
Journal of Cellular and Molecular Medicine
Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α‐HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic or infection‐induced)
Publikováno v:
Analytical Cellular Pathology, Vol 2021 (2021)
Analytical Cellular Pathology (Amsterdam)
Analytical Cellular Pathology (Amsterdam)
Abnormal expressions of long noncoding RNAs (lncRNAs) and protein-encoding messenger RNAs (mRNAs) are important for the development of childhood acute lymphoblastic leukemia (ALL). This study developed an lncRNA-mRNA integrated classifier for the pre
Autor:
Long Liu, Libo Wang, Dechao Jiao, Chunguang Guo, Taoyuan Lu, Yanli Wang, Zaoqu Liu, Zhaonan Li, Yanan Zhao, Xinwei Han
Publikováno v:
Journal of Cellular and Molecular Medicine
As essential regulators of gene expression, miRNAs are engaged in the initiation and progression of colorectal cancer (CRC), including antitumour immune response. In this study, we proposed an integrated algorithm, ImmuMiRNA, for identifying miRNA mo
Autor:
Chih-Chao Yang, John Y. Chiang, Yi-Chen Li, Pei-Hsun Sung, Hon-Kan Yip, Mel S. Lee, Kuan-Hung Chen, Tien-Hung Huang
Publikováno v:
Journal of Cellular and Molecular Medicine
This study tested the hypothesis that therapy with double overexpression of miR‐19a‐3p and miR‐20a‐5p (miRDOE) to human inducible pluripotent stem cell–derived mesenchymal stem cells (iPS‐MSCs) was superior to iPS‐MSCs alone for preserv
Publikováno v:
Journal of Cellular and Molecular Medicine
Long non‐coding RNA (lncRNA) is an important regulatory factor in the development of lung adenocarcinoma, which is related to the control of autophagy. LncRNA can also be used as a biomarker of prognosis in patients with lung adenocarcinoma. Theref