Zobrazeno 1 - 10
of 54
pro vyhledávání: '"59"'
Autor:
Xiaodong Teng, Jing Zhang, Qian Shen, He Cao, Xiao Teng, Zhen Chen, Yanting Yuan, Huisong Luo, Ke Huang
Publikováno v:
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
Background Lung cancer in young patients is rare and has unique clinicopathological features. However, the molecular features of lung cancer in these patients are unclear. In this study, we aimed to describe the molecular features and outcomes of lun
Autor:
Clara Ugolini, Luigi De Napoli, Elisabetta Macerola, Gabriele Materazzi, Fulvio Basolo, Vincenzo Condello, Cristina Romei, Rossella Elisei
Publikováno v:
Headneck. 40(8)
Background Circulating cell-free tumor DNA (ctDNA) in plasma is a promising noninvasive instrument for cancer monitoring. Detection of BRAFV600E on ctDNA of patients with papillary thyroid carcinoma (PTC) may represent an indicator of tumor aggressiv
Autor:
R. Bryan Rumble, Nancy Roach, Pamela B. Mangu, Richard L. Schilsky, Carmen J. Allegra, Alexander Hantel, Stanley R. Hamilton
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(2)
Purpose An American Society of Clinical Oncology Provisional Clinical Opinion (PCO) offers timely clinical direction after publication or presentation of potentially practice-changing data from major studies. This PCO update addresses the utility of
Autor:
Gilberto de Castro Junior, Pedro Henrique Xavier Nabuco-de-Araujo, Carlos Alberto Buchpiguel, Marina Henkin Behar, Guilherme Harada, Mariane Tami Amano, Fernanda Frozoni Antonacio
Publikováno v:
Clinical Lung Cancer. 22:e708-e711
Clinical Practice Points Immunotherapy based on immune checkpoint inhibitors (ICIs) either alone or in combination with platinum-based chemotherapy has dramatically changed the therapeutic scenario in non–small cell lung cancer. However, only a sub
Autor:
Keith T. Flaherty, Lyndsay Harris, April K.S. Salama, P. Mickey Williams, Carlos L. Arteaga, Alice P. Chen, Jong-In Park, Barbara A. Conley, Deborah K. Armstrong, Larry Rubinstein, Edith P. Mitchell, Robert Gray, James A. Zwiebel, Lisa M. McShane, Shuli Li, Helen X. Chen, Peter J. O'Dwyer, Erin Macrae, Stanley R. Hamilton, David Patton
Publikováno v:
Journal of Clinical Oncology. 38:3895-3904
PURPOSE BRAFV600 mutations are commonly found in melanoma and thyroid cancers and to a lesser degree in other tumor types. Subprotocol H (EAY131-H) of the NCI-MATCH platform trial sought to investigate the selective BRAF inhibitor dabrafenib and the
Autor:
Jason J. Luke, Gary K. Schwartz, David Hogg, Bruno R. Bastos, Carrie Strand, Daniel J Olson, Timothy Carll, Yuanyuan Zha, Pamela N. Munster, Marcus O. Butler, Jacob B. Allred, Riyue Bao, Brian W. Labadie
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 4
Clin Cancer Res
Clin Cancer Res
Purpose: The surface receptor MET is highly expressed on primary uveal melanoma; MET inhibitors demonstrated early clinical signals of efficacy in slowing uveal melanoma growth. The primary objective of our study was to compare the progression-free s
Autor:
Jaclyn F. Hechtman, Efsevia Vakiani, Monika Vyas, David S. Klimstra, Canan Firat, Avani Desai, Jinru Shia, Lik Hang Lee, Karuna Ganesh, Zsofia K. Stadler, Peter Ntiamoah, Liying Zhang, Arnold J. Markowitz, Martin R. Weiser, Neil H. Segal, Tao Wang
Publikováno v:
Modern Pathology. 32:1551-1562
Double somatic mismatch-repair-gene mutation/alteration is a recently recognized molecular mechanism that underlies microsatellite instability-high in some colorectal carcinomas. It remains to be determined whether and how microsatellite instability-
Autor:
Giorgio V. Scagliotti, Andrea Caglio, Tessa Sperone, Fabrizio Tabbò, Maria Lucia Reale, Francesco Passiglia, Massimo Di Maio, Paolo Bironzo, Angela Listì, Silvia Novello, Luisella Righi, Federico Bussolino
Publikováno v:
Cancers
Volume 13
Issue 10
Cancers, Vol 13, Iss 2425, p 2425 (2021)
Volume 13
Issue 10
Cancers, Vol 13, Iss 2425, p 2425 (2021)
Background: Tyrosine kinase inhibitors (TKIs) show variable efficacy in epidermal growth factor receptor mutation-positive (EGFR+) NSCLC patients, even in patients harbouring the same mutation. Co-alterations may predict different outcomes to TKIs. M
Autor:
Antony W. Burgess, Michael McCullough, Oliver M. Sieber, Kendrick Koo, Tim A. Iseli, Christopher Angel, David Wiesenfeld, Dmitri Mouradov
Publikováno v:
Cancers
Volume 13
Issue 5
Cancers, Vol 13, Iss 1029, p 1029 (2021)
Volume 13
Issue 5
Cancers, Vol 13, Iss 1029, p 1029 (2021)
Molecular alterations in 176 patients with oral squamous cell carcinomas (OSCC) were evaluated to delineate differences in non-smoking non-drinking (NSND) patients. Somatic mutations and DNA copy number variations (CNVs) in a 68-gene panel and human
Autor:
Myung-Ju Ahn, Tae Jung Kim, Tae Sung Kim, Keunchil Park, Bo Da Nam, Kyung Soo Lee, Yoon-La Choi, Myung Jin Chung
Publikováno v:
Clinical Lung Cancer. 20:e309-e316
Purpose To determine the outcomes of transthoracic rebiopsy for epidermal growth factor receptor (EGFR) mutation in patients with lung adenocarcinoma and to explore the clinical and procedure-related risk factors for the acquisition of nondiagnostic