Zobrazeno 1 - 10
of 2 406
pro vyhledávání: ''
Autor:
Wenjie Gao, Bo Gao, Xianjian Qiu, Dongsheng Huang, Jincheng Qiu, Pengfei Li, Hang Zhou, Zhancheng Liang, Zhihuai Deng, Wenjun Hu, Tongzhou Liang, Anjing Liang, Shaoguang Li, Taiqiu Chen
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. In this study, we found that RORα, a member of the retinoid-related orphan rece
Autor:
Henghui Zhang, Wei Zhou, Chao Wu, Ruyan Xie, Xianchao Guo, Jun Ji, Lei Zhang, Chenhong Peng, Fei Yuan, Ying Yang, Chao Wang, Min Shi, Jun Zhang
Publikováno v:
Cancer Immunology, Immunotherapy
Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-yea
Autor:
Ben Liu, Yufan Ying, Xueyou Ma, Xiao Wang, Xiangyi Zheng, Weiyu Wang, Liping Xie, Bo Xie, Haiyun Xie, Jiangfeng Li, Jian Wu, Jiajie Fang, Shiming Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (I
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
MicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquiti
Autor:
Shigeyuki Shichino, Hiromichi Nakajima, Yoshiaki Nakamura, Tetsuya Nakatsura, Satoshi Ueha, Manami Shimomura, Hiroyasu Aoki, Akihiro Sato, Kouji Matsushima, Takayuki Yoshino
Publikováno v:
Cancer Science
With the widespread use of programmed death receptor‐1 (PD‐1) blockade therapy, sensitive and specific predictive biomarkers that guide patient selection are urgently needed. T‐cell receptor (TCR) repertoire, which reflects antitumor T‐cell r
Publikováno v:
Journal of Immunotherapy. 44:234-238
Immunotherapy has revolutionized the treatment of advanced cutaneous squamous cell carcinoma. However, the role of immune checkpoint inhibitors for the treatment of Marjolin ulcer (MU), a rare cutaneous malignancy that arises from previously traumati
Autor:
Yusuke Kaida, Naoki Inui, Kazuki Furuhashi, Yusuke Inoue, Tomohiro Uto, Katsuhiro Yoshimura, Kazutaka Mori, Noriyuki Enomoto, Mitsuru Niwa, Hiroyuki Matsuda, Shun Matsuura, Yuzo Suzuki, Yutaro Nakamura, Masato Fujii, Masato Karayama, Hironao Hozumi, Mikio Toyoshima, Yasuhiro Ito, Takafumi Suda, Dai Hashimoto, Tomoyuki Fujisawa, Hideki Kusagaya, Takashi Matsui, Nao Inami, Kazuhiro Asada
Publikováno v:
Cancer Immunology, Immunotherapy
Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PF
Autor:
Eiji Takeuchi, Hisanori Machida, Naoki Kadota, Tsutomu Shinohara, Keishi Naruse, Yoshio Okano, Nobuo Hatakeyama, Yoshihiro Kondou, Katsuhiro Atagi
Publikováno v:
Cancer Immunology, Immunotherapy
Objective Tumor-related eosinophilia may have extended survival benefits for some cancer patients. However, there has been no report on the prognosis difference between eosinophilic pleural effusion (EPE) and non-EPE in lung cancer patients. Our stud
Autor:
Hojoon Lee, Hanlee P. Ji, Michael S. Binkley, Grady Day, Sarah Haebe, Steven R. Long, Brock A. Martin, Ronald Levy, Debra K. Czerwinski, Susan M. Grimes, Tanaya Shree, Anuja Sathe
Publikováno v:
Blood. 137:2869-2880
Tumor heterogeneity complicates biomarker development and fosters drug resistance in solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical implications is still limited. Here, we profiled 2 nodal, synchronously
Autor:
Jing-Jing Jiang, Masaaki Murakami, Ikuma Nakagawa, Shuhei Shimoyama, Shintaro Hojyo, Osamu Ohara, Tatsuya Atsumi, Mona Uchida, Isao Matsumoto, John A. Chiorini, Mitsutoshi Ota, Yuki Tanaka, Rie Hasebe, Daisuke Kamimura, Yoshinori Hasegawa
Publikováno v:
Int Immunol
Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Although many genome-wide association studies have revealed disease-associated risk alleles, the func