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Autor:
Henghui Zhang, Wei Zhou, Chao Wu, Ruyan Xie, Xianchao Guo, Jun Ji, Lei Zhang, Chenhong Peng, Fei Yuan, Ying Yang, Chao Wang, Min Shi, Jun Zhang
Publikováno v:
Cancer Immunology, Immunotherapy
Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-yea
Autor:
Shigeyuki Shichino, Hiromichi Nakajima, Yoshiaki Nakamura, Tetsuya Nakatsura, Satoshi Ueha, Manami Shimomura, Hiroyasu Aoki, Akihiro Sato, Kouji Matsushima, Takayuki Yoshino
Publikováno v:
Cancer Science
With the widespread use of programmed death receptor‐1 (PD‐1) blockade therapy, sensitive and specific predictive biomarkers that guide patient selection are urgently needed. T‐cell receptor (TCR) repertoire, which reflects antitumor T‐cell r
Publikováno v:
Journal of Immunotherapy. 44:234-238
Immunotherapy has revolutionized the treatment of advanced cutaneous squamous cell carcinoma. However, the role of immune checkpoint inhibitors for the treatment of Marjolin ulcer (MU), a rare cutaneous malignancy that arises from previously traumati
Autor:
Yusuke Kaida, Naoki Inui, Kazuki Furuhashi, Yusuke Inoue, Tomohiro Uto, Katsuhiro Yoshimura, Kazutaka Mori, Noriyuki Enomoto, Mitsuru Niwa, Hiroyuki Matsuda, Shun Matsuura, Yuzo Suzuki, Yutaro Nakamura, Masato Fujii, Masato Karayama, Hironao Hozumi, Mikio Toyoshima, Yasuhiro Ito, Takafumi Suda, Dai Hashimoto, Tomoyuki Fujisawa, Hideki Kusagaya, Takashi Matsui, Nao Inami, Kazuhiro Asada
Publikováno v:
Cancer Immunology, Immunotherapy
Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PF
Autor:
Eiji Takeuchi, Hisanori Machida, Naoki Kadota, Tsutomu Shinohara, Keishi Naruse, Yoshio Okano, Nobuo Hatakeyama, Yoshihiro Kondou, Katsuhiro Atagi
Publikováno v:
Cancer Immunology, Immunotherapy
Objective Tumor-related eosinophilia may have extended survival benefits for some cancer patients. However, there has been no report on the prognosis difference between eosinophilic pleural effusion (EPE) and non-EPE in lung cancer patients. Our stud
Autor:
Alessandro Paniccia, Derek Barclay, Yoram Vodovotz, Jacob C. Hodges, Michael T. Lotze, Pranav Murthy, Amer H. Zureikat, Brian A. Boone, Randall E. Brand, Ruben Zamora, Kenneth K. Lee, Asmita Chopra, Richard L. Simmons
Publikováno v:
J Immunother
Despite its increased application in pancreatic ductal adenocarcinoma (PDAC), complete response to neoadjuvant therapy (NAT) is rare. Given the critical role of host immunity in regulating cancer, we sought to correlate baseline inflammatory profiles
Autor:
Feng Xinxin, Hailin Jia, Dongxiao Cai, Jing Wang, Huanlong Liu, Diandong Jiang, Bo Han, Li Zhang, Wei Sun
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-18 (2021)
Cell Death & Disease
Cell Death & Disease
Myocarditis (MC) is a common, potentially life-threatening inflammatory disease of the myocardium. A growing body of evidence has shown that mitogen-activated protein kinase 14 (MAPK14) participates in the pathogenesis of MC. However, the upstream re
Autor:
Jürgen C. Becker, Stephan Grabbe, Ulrike Leiter, Henner Stege, Claudia Pföhler, Peter Mohr, Jessica C. Hassel, Carmen Loquai, S. Schultheis, Felix Kiecker, S. Ugurel, Maximilian Haist, Patrick Terheyden, Markus Meissner, Maria Isabel Fleischer, J. Kleeman, A. Thiem
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors (ICI) have led to a prolongation of progression-free and overall survival in patients with metastatic Merkel cell carcinoma (MCC). However, immune-mediated adverse events due to ICI therapy are common and often
Autor:
Hideki Ueno, Chigusa Morizane, Shuichi Mitsunaga, Masafumi Ikeda, Yasunori Ushida, Kazuto Gemmoto, Shunsuke Kondo, Takuji Okusaka, Hideaki Suna, Junji Furuse, Izumi Ohno
Publikováno v:
Immunotherapy. 13:371-385
Aim: Two peptide cocktail vaccines using glypican-3, WD-repeat-containing protein up-regulated in hepatocellular carcinoma (HCC) and nei endonuclease VIII-like three epitopes were evaluated in advanced HCC in two Phase I studies. Patients & methods:
Autor:
Michael B. Atkins, Dongyu Zhang, Tomi Akinyemiju, Tina D. Tailor, Chul Kim, Dejana Braithwaite
Publikováno v:
J Immunother
In patients with metastatic non-small cell lung cancer (mNSCLC), the extent to which immunotherapy utilization rate varies by comorbidities is unclear. Using the National Cancer Database (NCDB) from 2015 to 2016, we assessed the association between l