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Autor:
Richard Greil, Armin Gerger, Renate Schaberl-Moser, Martin Pichler, Dominik A. Barth, Michael Stotz, Angela Djanani, Antonia Gantschnigg, Lena Horvath, Jakob M. Riedl, Herbert Stöger, Felix Renneberg, Konstantin Schlick, Christopher Rossmann, Florian Posch, Esther Schwarzenbacher, Florian Moik
Publikováno v:
European Journal of Cancer. 151:3-13
Background Gemcitabine/nab-paclitaxel (GN) and FOLFIRINOX are standard first-line treatment options for advanced pancreatic ductal adenocarcinoma (aPDAC), but currently no prospective randomised head-to-head comparison between these treatments has ye
Autor:
Liang Jin, Heran Deng, Nanyan Rao, Jiewen Chen, Yandan Yao, Yaping Yang, Zhanghai He, Yan Nie, Wei Wu, Jieqiong Liu, Fengxi Su
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer
BMC Cancer
BackgroundHere we evaluated the feasibility, efficacy, tolerability, and treatment-mediated immune modulation of neoadjuvant everolimus plus letrozole versus chemotherapy in treating postmenopausal patients with ER-positive, HER2-negative breast canc
Autor:
Rebeca Lozano, Gerhardt Attard, Ugo De Giorgi, Enrique Gonzalez-Billalabeitia, Giuseppe Schepisi, Isabel M. Aragón, Vincenza Conteduca, David Olmos, Daniel Wetterskog, Begoña Mellado, Nuria Romero-Laorden, Nicole Brighi, Emanuela Scarpi, Anuradha Jayaram, Cristian Lolli, Chiara Casadei, Mercedes Marín-Aguilera, Elena Castro, Giorgia Gurioli, Anna Wingate
Publikováno v:
Università degli studi di Foggia-IRIS
Background: Plasma AR status has been identified as a potential biomarker of response in metastatic castration-resistant prostate cancer (mCRPC) patients receiving docetaxel or AR-targeted therapies. However, the relevance of plasma AR in the overall
Autor:
Geraldine M. Jacobson, Gary Marano, Timothy D. Eubank, Malcolm D. Mattes, Patrick C. Ma, Mohammed Almubarak, Sijin Wen
Publikováno v:
Clin Lung Cancer
INTRODUCTION/BACKGROUND: This study assessed the safety and systemic (abscopal) response from the addition of local stereotactic body radiation therapy (SBRT) to checkpoint inhibitor (CPI) immunotherapy in patients with metastatic non-small cell lung
Autor:
Reza Sari Motlagh, Jeremy Yuen-Chun Teoh, Shin Egawa, Benjamin Pradere, Ekaterina Laukhtina, Thomas Powles, Keiichiro Mori, Victor M. Schuettfort, Marco Moschini, Francesco Soria, Shahrokh F. Shariat, Hadi Mostafaei
Publikováno v:
European Journal of Cancer. 151:35-48
Introduction Platinum-based combination chemotherapy is the standard treatment for patients with chemotherapy-eligible metastatic urothelial carcinoma (mUC). Immune-checkpoint inhibitors (ICIs) are currently assessed in this setting. This review aime
Autor:
Hiroki Ishihara, Takashi Ikeda, Hiroaki Shimmura, Toshio Takagi, Hideki Ishida, Kazunari Tanabe, Junpei Iizuka, Kazutaka Nakamura, Hidekazu Tachibana, Kazuhiko Yoshida, Hirohito Kobayashi, Hironori Fukuda, Yasunobu Hashimoto, Tsunenori Kondo, Yuki Nemoto
Publikováno v:
Targeted Oncology. 16:493-502
It remains unclear how early treatment interruption of nivolumab plus ipilimumab due to immune-related adverse events affects the outcome of previously untreated metastatic renal cell carcinoma (mRCC). To investigate the prognostic impact of the earl
Publikováno v:
Breast Disease. 40:S33-S37
BACKGROUND: Increased plasma aldehyde dehydrogenase 1 (ALDH1) levels have been proposed to predict cancer chemoresistance. However, studies have reported inconsistent results, depending on the type of cancer cells used. OBJECTIVE: This study aimed to
Autor:
Shengmin Chen, Weifeng Wang, Huanliang Wu, Feng Yuan, Zhiren Lin, Gang Cheng, Shaohua Peng, Yunxiu Luo
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:2913-2922
Assessing the downstaging effects of neoadjuvant chemotherapy (NACT) in patients with locally advanced nasopharyngeal carcinoma (LANPC) and predicting response to treatment remain challenging. The present study aimed to evaluate the long-term prognos
Autor:
Marcello Ferreti Fanelli, Marcia Torresan Delamain, Fernando Augusto Soares, Carmen Silvia Passos Lima, Angelo Borsarelli Carvalho Brito, Carmino Antonio De Souza, José Vassallo
Publikováno v:
Tumor Biology. 43:129-140
OBJECTIVES: Single nucleotide variants (SNVs) in vascular endothelial growth factor A (VEGFA) and VEGFA receptor (KDR) genes confer different inherited abilities in angiogenesis (AG) pathway. We aimed in the present study to evaluate influence of six
Publikováno v:
Journal of Immunotherapy. 44:234-238
Immunotherapy has revolutionized the treatment of advanced cutaneous squamous cell carcinoma. However, the role of immune checkpoint inhibitors for the treatment of Marjolin ulcer (MU), a rare cutaneous malignancy that arises from previously traumati